Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Dashyant Dhanak"'
Autor:
Nannan Liu, Michael N. Zimmerman, Richard M. Keenan, Victor K. Johnston, Deping Chai, Rosanna Tedesco, Duke M. Fitch, Juili Lin-Goerke, Kenneth Wiggall, Antony N. Shaw, Nestor O. Concha, Ramesh Bambal, Michael G. Darcy, Robert T. Sarisky, Dashyant Dhanak, Kevin J. Duffy, Adam T. Gates
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4350-4353
The synthesis and optimisation of HCV NS5B polymerase inhibitors with improved potency versus the existing compound 1 is described. Substitution in the benzothiadiazine portion of the molecule, furnishing improvement in potency in the high protein Re
Autor:
Steven D. Knight, Richard M. Keenan, James J. Foley, Diane Naselsky, Ralph A. Rivero, Kevin L. Salyers, Stephen A. Douglas, Anthony Sapienza, Nambi Aiyar, Ming An, Jian Jin, Dashyant Dhanak, Henry M. Sarau
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3950-3954
SAR exploration of the central diamine, benzyl, and terminal aminoalkoxy regions of the N-cyclic azaalkyl benzamide series led to the identification of very potent human urotensin-II receptor antagonists such as 1a with a Ki of 4 nM. The synthesis an
Autor:
Thomas J. Carr, Dashyant Dhanak, David Haigh, George Burton, Victor K. Johnson, Pia Thommes, Glenn A. Hofmann, Robert T. Sarisky, Martin John Slater, Juili Lin-Goerke, Thomas W. Ku, Nigel R. Parry, Terry Kiesow
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1930-1933
The SAR development is described for a series of N -acyl pyrrolidine inhibitors of the Hepatitis C virus RNA-dependent RNA polymerase, NS5B, from tractable Δ21 enzyme inhibitors to an example with antiviral activity in a cellular assay (HCV replicon
Autor:
Rosanna Tedesco, Duke M. Fitch, Robert T. Sarisky, Antony N. Shaw, Michael N. Zimmerman, Kevin J. Duffy, Michael G. Darcy, Dashyant Dhanak, Juili Lin-Goerke, Richard M. Keenan, Adam T. Gates, Victor K. Johnston, Deping Chai, Kenneth Wiggall, Klára Valkó
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
Modification of the benzo rings of 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones into heteroaromatic systems was investigated to enhance physicochemical properties and potency profile of this class of inhibitors. The synt