Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Richard H. Gomer"'
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-12 (2022)
Abstract Background Sialic acid is often the distal sugar on glycoconjugates, and sialidases are enzymes that remove this sugar. In fibrotic lesions in human and mouse lungs, there is extensive desialylation of glycoconjugates, and upregulation of si
Externí odkaz:
https://doaj.org/article/daede1f497744dc4b867b7f035d23b31
Publikováno v:
BMC Immunology, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background Circulating bone marrow-derived monocytes can leave the blood, enter a tissue, and differentiate into M1 inflammatory, M2a remodeling/fibrotic, or M2c/Mreg resolving/immune-regulatory macrophages. Macrophages can also convert from
Externí odkaz:
https://doaj.org/article/c863dd59857e4551b6dc6f4d48aa62fe
Publikováno v:
Am J Pathol
High-fat diet (HFD)–induced inflammation and steatosis of adipose tissue and liver are associated with a variety of serious health risks. Sialic acids are found as the distal terminal sugar on glycoproteins, which are removed by sialidases (neurami
Publikováno v:
Am J Pathol
High-fat diet (HFD)-induced inflammation is associated with a variety of health risks. The systemic pentraxin serum amyloid P (SAP) inhibits inflammation. SAP activates the high-affinity IgG receptor Fcγ receptor I (FcγRI; CD64) and the lectin rece
Publikováno v:
J Immunol
Fibrocytes are monocyte-derived fibroblast like cells that participate in wound healing, but little is known about what initiates fibrocyte differentiation. Blood platelets contain 60–100-mer polymers of phosphate groups called polyphosphate, and w
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245924 (2021)
PLoS ONE
bioRxiv
PLoS ONE
bioRxiv
SARS-CoV-2 is a single stranded RNA (ssRNA) virus and contains GU-rich sequences distributed abundantly in the genome. In COVID-19, the infection and immune hyperactivation causes accumulation of inflammatory immune cells, blood clots, and protein ag
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244762 (2020)
PLoS ONE
PLoS ONE
Non-alcoholic fatty liver disease (NAFLD) is associated with obesity and type 2 diabetes and is characterized by the accumulation of fat in the liver (steatosis). NAFLD can transition into non-alcoholic steatohepatitis (NASH), with liver cell injury,
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Pulmonary fibrosis involves the formation of inappropriate scar tissue in the lungs, but what drives fibrosis is unclear. Sialidases (also called neuraminidases) cleave terminal sialic acids from glycoconjugates. In humans and mice, pulmonary fibrosi
Autor:
Sarah E. Herlihy, Richard H. Gomer, Monica L Brown, Brad R. Weeks, Darrell Pilling, Linda K. Myers
Publikováno v:
Arthritis & Rheumatology. 67:2634-2638
Objective To determine whether an intraarticular injection of the neutrophil chemorepellent dipeptidyl peptidase IV (DPPIV; CD26) can attenuate inflammation and decrease the severity of arthritis in a murine model. Methods DBA/1 mice were immunized w
Publikováno v:
Proceedings of the National Academy of Sciences. 112:8385-8390
Fibrosis is caused by scar tissue formation in internal organs and is associated with 45% of deaths in the United States. Two closely related human serum proteins, serum amyloid P (SAP) and C-reactive protein (CRP), strongly affect fibrosis. In multi