Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Olga Garaschuk"'
Autor:
Nestor L. Uzcategui, Sena Güçer, Cris Richter, Annika Speidel, Elizabeta Zirdum, Michael Duszenko, Olga Garaschuk, Katherine Figarella
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionInvasion of the central nervous system (CNS) is the most serious consequence of Trypanosoma brucei infection, which causes sleeping sickness. Recent experimental data have revealed some more insights into the disease during the meningoenc
Externí odkaz:
https://doaj.org/article/0f9fbc8aa1e74858aca4939bec30f804
Publikováno v:
Antioxidants, Vol 10, Iss 11, p 1715 (2021)
Neural tissue is one of the main oxygen consumers in the mammalian body, and a plentitude of metabolic as well as signaling processes within the brain is accompanied by the generation of reactive oxygen (ROS) and nitrogen (RNS) species. Besides the i
Externí odkaz:
https://doaj.org/article/248898239a194cba905d82966d0bf130
Autor:
Nithi Asavapanumas, Michael T. Heneka, Nima Mojtahedi, Olga Garaschuk, Karin Odoj, Bianca Brawek
Publikováno v:
Brain, behavior and immunity 96, 113-126 (2021). doi:10.1016/j.bbi.2021.05.021
Peripheral inflammation is known to impact brain function, resulting in lethargy, loss of appetite and impaired cognitive abilities. However, the channels for information transfer from the periphery to the brain, the corresponding signaling molecules
Autor:
Michael T. Heneka, Daria Savitska, Elizabeta Zirdum, Bianca Brawek, Nicole Fröhlich, Nima Mojtahedi, Olga Garaschuk, Karin Riester
Publikováno v:
Brain, behavior and immunity 87, 243-255 (2020). doi:10.1016/j.bbi.2019.12.007
Peripheral inflammation is known to trigger a mirror inflammatory response in the brain, involving brain's innate immune cells - microglia. However, the functional phenotypes, which these cells adopt in the course of peripheral inflammation, remain o
Autor:
Olga Garaschuk
Publikováno v:
Neural Regeneration Research
Neural Regeneration Research, Vol 16, Iss 2, Pp 294-295 (2021)
Neural Regeneration Research, Vol 16, Iss 2, Pp 294-295 (2021)
Autor:
Chommanad, Lerdkrai, Nithi, Asavapanumas, Bianca, Brawek, Yury, Kovalchuk, Nima, Mojtahedi, Maria, Olmedillas Del Moral, Olga, Garaschuk
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(6)
Although both patients with Alzheimer’s disease (AD) and mouse models of the disease suffer from a profound neuronal hyperactivity mediating an impairment of memory and cognition, the underlying mechanisms remain elusive. Here, we show that neurona
Autor:
Bianca Brawek, Olga Garaschuk
Publikováno v:
Cell calcium. 64
Microglia, the innate immune cells of the brain, are becoming increasingly recognized as an important player both in the context of physiological brain function and brain pathology. To fulfill their executive functions microglia can modify their morp
Autor:
Bianca Brawek, Olga Garaschuk
Publikováno v:
Cell Calcium. 53:159-169
Microglial cells are the resident immune cells of the CNS. They mediate innate immune response of the brain to injury, inflammation and neurodegenerative diseases. Apart from their role in disease they are critically involved in the development and p
Autor:
Koji Yamanaka, Jari Koistinaho, Douglas T. Golenbock, Terrence Town, Guy C. Brown, Erik Boddeke, Monica J. Carson, V. Hugh Perry, Gabor C. Petzold, Olga Garaschuk, David J. Brooks, Markus P. Kummer, John C.S. Breitner, Nikolaus Deigendesch, Frederic Brosseron, Greg M. Cole, Nicolas G. Bazan, Stéphane Hunot, Michael T. Heneka, Dave Morgan, Javier Vitorica, Gary E. Landreth, Clive Holmes, Eicke Latz, Bertrand Joseph, Annett Halle, Charles A. Dinarello, Mari L. Shinohara, Joseph El Khoury, Douglas L. Feinstein, Andreas H. Jacobs, Tony Wyss-Coray, Alexei Verkhratsky, Karl Herrup, Richard M. Ransohoff, Sally A. Frautschy, Bente Finsen
Publikováno v:
The Lancet. Neurology, vol 14, iss 4
ResearcherID
The lancet / Neurology 14(4), 388-405 (2015). doi:10.1016/S1474-4422(15)70016-5
Lancet Neurology, 14, 388-405
Heneka, MT; Carson, MJ; Khoury, JE; Landreth, GE; Brosseron, F; Feinstein, DL; et al.(2015). Neuroinflammation in Alzheimer's disease. The Lancet Neurology, 14(4), 388-405. doi: 10.1016/S1474-4422(15)70016-5. UCLA: Retrieved from: http://www.escholarship.org/uc/item/99h2f9m1
Lancet Neurology, 14, 4, pp. 388-405
Heneka, M T, Carson, M J, Khoury, J E, Landreth, G E, Brosseron, F, Feinstein, D L, Jacobs, A H, Wyss-Coray, T, Vitorica, J, Ransohoff, R M, Herrup, K, Frautschy, S A, Finsen, B, Brown, G C, Verkhratsky, A, Yamanaka, K, Koistinaho, J, Latz, E, Halle, A, Petzold, G C, Town, T, Morgan, D, Shinohara, M L, Perry, V H, Holmes, C, Bazan, N G, Brooks, D J, Hunot, S, Joseph, B, Deigendesch, N, Garaschuk, O, Boddeke, E, Dinarello, C A, Breitner, J C, Cole, G M, Golenbock, D T & Kummer, M P 2015, ' Neuroinflammation in Alzheimer's disease ', Lancet Neurology, vol. 14, no. 4, pp. 388-405 . https://doi.org/10.1016/S1474-4422(15)70016-5
The Lancet Neurology
ResearcherID
The lancet
Lancet Neurology, 14, 388-405
Heneka, MT; Carson, MJ; Khoury, JE; Landreth, GE; Brosseron, F; Feinstein, DL; et al.(2015). Neuroinflammation in Alzheimer's disease. The Lancet Neurology, 14(4), 388-405. doi: 10.1016/S1474-4422(15)70016-5. UCLA: Retrieved from: http://www.escholarship.org/uc/item/99h2f9m1
Lancet Neurology, 14, 4, pp. 388-405
Heneka, M T, Carson, M J, Khoury, J E, Landreth, G E, Brosseron, F, Feinstein, D L, Jacobs, A H, Wyss-Coray, T, Vitorica, J, Ransohoff, R M, Herrup, K, Frautschy, S A, Finsen, B, Brown, G C, Verkhratsky, A, Yamanaka, K, Koistinaho, J, Latz, E, Halle, A, Petzold, G C, Town, T, Morgan, D, Shinohara, M L, Perry, V H, Holmes, C, Bazan, N G, Brooks, D J, Hunot, S, Joseph, B, Deigendesch, N, Garaschuk, O, Boddeke, E, Dinarello, C A, Breitner, J C, Cole, G M, Golenbock, D T & Kummer, M P 2015, ' Neuroinflammation in Alzheimer's disease ', Lancet Neurology, vol. 14, no. 4, pp. 388-405 . https://doi.org/10.1016/S1474-4422(15)70016-5
The Lancet Neurology
Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment but strongly interacts with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2286134b7cbed70b5343d6eb0d1252b3
https://escholarship.org/uc/item/99h2f9m1
https://escholarship.org/uc/item/99h2f9m1
Autor:
Bianca Brawek, Olga Garaschuk
Publikováno v:
Cell and tissue research. 357(2)
Dysregulation of intracellular Ca(2+) homeostasis has been proposed as a common proximal cause of neural dysfunction during aging and Alzheimer's disease (AD). In this context, aberrant Ca(2+) signaling has been viewed as a neuronal phenomenon mostly