Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Benjamin Ng"'
Publikováno v:
Experimental & Molecular Medicine
Interleukin (IL)-11 evolved as part of the innate immune response. In the human lung, IL-11 upregulation has been associated with viral infections and a range of fibroinflammatory diseases, including idiopathic pulmonary fibrosis. Transforming growth
Autor:
Wei-Wen Lim, Jinrui Dong, Benjamin Ng, Anissa A. Widjaja, Chen Xie, Liping Su, Xiu-Yi Kwek, Nicole G.Z. Tee, Chee Jian Pua, Sebastian Schafer, Sivakumar Viswanathan, Stuart A. Cook
Publikováno v:
Circulation research. 130(5)
Background: Marfan syndrome (MFS) is associated with TGF (transforming growth factor) β–stimulated ERK (extracellular signal-regulated kinase) activity in vascular smooth muscle cells (VSMCs), which adopt a mixed synthetic/contractile phenotype. I
Autor:
Salvatore Albani, Sonia Chothani, Anissa A. Widjaja, Sivakumar Viswanathan, Mao Wang, Bhairav Paleja, Jessie Tan, Benjamin Ng, Sebastian Schafer, Jinrui Dong, Eleonora Adami, Stella Lim, Stuart A. Cook, Nicole S. J. Ko
Publikováno v:
The FASEB Journal. 34:11802-11815
Repetitive pulmonary injury causes fibrosis and inflammation that underlies chronic lung diseases such as idiopathic pulmonary fibrosis (IPF). Interleukin 11 (IL11) is important for pulmonary fibroblast activation but the contribution of fibroblast-s
Autor:
Benjamin Ng, Sivakumar Viswanathan, Anissa A. Widjaja, Wei-Wen Lim, Shamini G. Shekeran, Joyce Wei Ting Goh, Jessie Tan, Fathima Kuthubudeen, Sze Yun Lim, Chen Xie, Sebastian Schafer, Eleonora Adami, Stuart A. Cook
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3549
Interleukin-11 (IL11) is important for fibrosis and inflammation, but its role in the pancreas is unclear. In pancreatitis, fibrosis, inflammation and organ dysfunction are associated with pancreatic stellate cell (PSC)-to-myofibroblast transformatio
Autor:
Jessie Tan, Shamini Guna Shekeran, Benjamin Ng, Sivakumar Viswanathan, Sonia Chothani, Anissa A. Widjaja, Sebastian Schafer, Stuart A. Cook, Stella Lim, Jinrui Dong
Genetic loss of function (LOF) in IL11RA infers IL11 signaling as important for fertility, fibrosis, inflammation and craniosynostosis. The impact of genetic LOF in IL11 has not been characterized. We generated IL11-knockout (Il11-/-) mice, which are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fc63bee23c5b1cfd6ad2560c44e80cb
https://doi.org/10.1101/2020.12.10.420695
https://doi.org/10.1101/2020.12.10.420695
Autor:
Jinrui Dong, Brijesh K. Singh, Sze-Yun Lim, Benjamin Ng, Shamini Guna Shekeran, Jin Zhou, Nicole S. J. Ko, Sonia Chothani, Stuart A. Cook, Tan J, Sebastian Schafer, W. Lim, Pei Min Lio, Anissa A. Widjaja, Paul M. Yen, Eleonora Adami, Sivakumar Viswanathan, Mao Wang
Background and aimsIL11 signaling is important in non-alcoholic steatohepatitis (NASH) but how it contributes to NASH pathologies beyond fibrosis is not known. Here we investigate the role of IL11 signaling in hepatocyte lipotoxicity.MethodsHepatocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99bbae0131f320fd3b4181eeb825b925
https://doi.org/10.1101/2020.03.11.986802
https://doi.org/10.1101/2020.03.11.986802
Autor:
Anissa A. Widjaja, Nicole Sj. Ko, Benjamin Ng, Jessie Tan, Mao Wang, Eleonora Adami, Stuart A. Cook, Jinrui Dong, Stella Lim, Sebastian Schafer, Sonia Chothani, Sivakumar Viswanathan, Salvatore Albani, Bhairav Paleja
Tissue injury leads to activation of resident stromal, parenchymal and immune cells to initiate reparative processes that, if unresolved, can lead to fibrosis and organ damage. The directionality of effect between fibrosis and inflammation in the lun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59918f2519b31566e3b01afb77810f08
Autor:
Chen Xie, Liping Su, Sebastian Schafer, Sze-Yun Lim, Xiu-Yi Kwek, W. Lim, Benjamin Ng, Nicole S. J. Ko, Stuart A. Cook, Anissa A. Widjaja, Stella Lim
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 1, p e0227505 (2020)
PLoS ONE, Vol 15, Iss 1, p e0227505 (2020)
Interleukin 11 (IL11) is a profibrotic cytokine, secreted by myofibroblasts and damaged epithelial cells. Smooth muscle cells (SMCs) also secrete IL11 under pathological conditions and express the IL11 receptor. Here we examined the effects of SMC-sp
Autor:
Anne Rabes, Stuart A. Cook, Salvatore Albani, Paul M. Yen, Rohit A. Sinha, Anissa A. Widjaja, Jessie Tan, Sonia Chothani, Sze Yun Lim, Madhulika Tripathi, Benjamin Ng, Eveline Bruinstroop, Sivakumar Viswanathan, Sebastian Schafer, Giuseppe D'Agostino, Jinrui Dong, Eleonora Adami, Martina Sombetzki, W. Lim, Bhairav Paleja, Brijesh K. Singh
The transformation of hepatic stellate cells (HSCs) into myofibroblasts is the defining pathobiology in non-alcoholic steatohepatitis (NASH). Here we show that key NASH factors induce IL-11, which drives an autocrine and ERK-dependent activation loop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9597a24bef1f5d8a33a14de82e298d7
https://doi.org/10.1101/470062
https://doi.org/10.1101/470062