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Autor:
Jia-Nan, Wang, Fang, Wang, Jing, Ke, Zeng, Li, Chuan-Hui, Xu, Qin, Yang, Xin, Chen, Xiao-Yan, He, Yuan, He, Xiao-Guo, Suo, Chao, Li, Ju-Tao, Yu, Ling, Jiang, Wei-Jian, Ni, Juan, Jin, Ming-Ming, Liu, Wei, Shao, Chen, Yang, Qian, Gong, Hai-Yong, Chen, Jun, Li, Yong-Gui, Wu, Xiao-Ming, Meng
Publikováno v:
Science translational medicine. 14(640)
The role of
Autor:
Jia-gen Wen, Jun Li, Biao Wei, Yong-Gui Wu, Hai-Di Li, Li Gao, Qin Yang, Jia-Nan Wang, Xiao-Ming Meng, Qiu-Ying Ma, Ling Jiang, Xue-Qi Liu
Publikováno v:
The FASEB Journal. 33:3523-3535
MLKL is a central mediator for necroptosis. Its knockout significantly relieves acute kidney injury (AKI). However, its upstream regulatory mechanism in AKI has not been fully elucidated. We recently reviewed how microRNAs (miRNAs), a type of well-st
Autor:
Fang Wang, Chao Li, Yu-Ting Cai, Juan Jin, Xue-Qi Liu, Biao Wei, Xiao-Ming Meng, Tian Xing, Ling Jiang, Hai-Yong Chen, Jia-gen Wen, Xin Chen, Xiao-Yan He, Qin Yang, Jia-Nan Wang, Taotao Ma, Li Gao, Jun Li, Chen Yang
Publikováno v:
Redox Biology
Redox Biology, Vol 32, Iss, Pp-(2020)
Redox Biology, Vol 32, Iss, Pp-(2020)
The incidence and severity of acute kidney injury (AKI) is increased yearly in diabetic patients. Although the mechanisms for this remain unclear, the prevention of AKI in diabetic nephropathy is feasible and of value. As we detected highly activatio
Autor:
Ling Jiang, Biao Wei, Xue-Qi Liu, Jun Li, Qiu-Ying Ma, Fan-rong Wu, Jia-gen Wen, Qin Yang, Luyu Zhou, Jia-Nan Wang, Tao tao Ma, Hai-Di Li, Li Gao, Xiao-Ming Meng
Publikováno v:
Free Radical Biology and Medicine. 124:466-472
Reactive oxygen species derived from NADPH oxidase contribute to a wide variety of renal diseases. Nox4, the major NADPH isoform in kidney, produces mainly H2O2 that regulates physiological functions. Nox4 contributes to redox processes involved in d
Autor:
Yu-hang Dong, Yong-Gui Wu, Yao Zhang, Jun Li, Jin-Fang Ge, Qin Yang, Jia-Nan Wang, Xiao-Ming Meng, Ju-tao Yu, Juan Jin, Hai-Di Li, Xiao-wei Hu, Hai-Yong Chen
Publikováno v:
Pharmacological Research. 163:105286
Alcohol consumption is one of the risk factors for kidney injury. The underlying mechanism of alcohol-induced kidney injury remains largely unknown. We previously found that the kidney in a mouse model of alcoholic kidney injury had severe inflammati
Autor:
Ling Jiang, Xiao-Ming Meng, Xue-Qi Liu, Zang Hongmei, Cheng Huang, Ming-Ming Liu, Biao Wei, Jun Li, Hai-Di Li, Gui-Ling Ren, Wei-Feng Wu, Qin Yang, Jia-Nan Wang, Qiu-Ying Ma, Li Gao, Cheng Jiang
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 98(7)
E-cadherin is a major component of tubular adherent proteins that maintain intercellular contacts and cell polarity in epithelial tissue. It is involved in pathological processes of renal cell carcinoma and fibrotic diseases via epithelial–mesenchy