Zobrazeno 1 - 10
of 26
pro vyhledávání: 'Lüllmann-Rauch, Renate'
Autor:
Sebastian Franken, Volkmar Gieselmann, Ulrich Matzner, Renate Lüllmann-Rauch, Dieter Hartmann
Publikováno v:
Histochemistry and Cell Biology. 116:161-169
The inherited deficiency of arylsulfatase A (ASA) causes lysosomal accumulation of sulfoglycolipids (mainly sulfo-galactosylceramide, S-GalCer ) and leads to metachromatic leukodystrophy in humans. Among visceral organs, kidneys are particularly affe
Autor:
Nina Himmerkus, Paul Saftig, Irina Pleines, Friedrich Koch-Nolte, Markus Bleich, Renate Lüllmann-Rauch, Zane Orinska, Bernhard Nieswandt, Bernd Schröder, Jenny Schröder
Publikováno v:
Molecular and cellular biology. 29(4)
CD63 is a member of the tetraspanin superfamily that constitutes a main component of the lysosomal membrane. In mice, two CD63 gene loci are present, with only one of these two being functional. We generated and analyzed mice deficient for active CD6
Publikováno v:
Xenobiotica. 20:1259-1267
1. Drug accumulation without a concomitant elevation of blood level may occur if the capacity of the tissue to bind drug increases during chronic treatment. 2. This special type of accumulation is found with cationic-amphiphilic drugs, which induce t
Autor:
Renate Lüllmann-Rauch
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 286:165-179
Lymphocytes of rat lymph nodes have previously been revealed as reliable and sensitive indicators of a particular drug side effect, notably a generalized phospholipidosis, inducible by a compound of amphiphilic character (chlorphentermine). The purpo
Publikováno v:
Toxicology. 44:45-59
The purpose of this study was to test whether or not the antiviral drug amantadine induces the structural features of lipidosis in intact animals (rats) and cultured cells, and to investigate the interactions between amantadine and phospholipids. Chl
Publikováno v:
Virchows Archiv B Cell Pathology. 11:167-181
After chronic administration of the anorectic drug Chlorphentermine the alveolar spaces of rat pulmonary tissue are filled with huge, free “foam cells”, which disappear after discontinuing the drug treatment. Ultrastructurally, these cells are he
Autor:
Renate Lüllmann-Rauch
Publikováno v:
Virchows Archiv B Cell Pathology. 12:295-302
Chlorphentermine, an anorectic drug, was administered to pregnant rats during the second half of gravidity. In pulmonary and cardiac tissues of the corresponding foetuses ultrastructural alterations were observed, which closely resembled those previo
Autor:
Renate Lüllmann-Rauch
Publikováno v:
Cell and tissue research. 169(4)
Rats were treated with several amphiphilic, cationic compounds that are known to cause generalized lipidosis (chlorphentermine, iprindole, 1-chloro-amitriptyline, clomipramine). After prolonged drug treatment the neurohypophysis showed severe morphol
Autor:
Renate Lüllmann-Rauch, J.S. Gillespie
Publikováno v:
Cell and Tissue Research. 149
The rat anococcygeus muscle, which is known from previous functional and histochemical investigations to be a smooth muscle with a dense adrenergic innervation, was studied by electron microscopic methods. The muscle was found to be organized in smal
Autor:
Renate Lüllmann-Rauch
Publikováno v:
Virchows Archiv. B, Cell pathology. 18(1)
Histological, histochemical and ultrastructural examinations were performed on renal tissues of rats after prolonged oral administration of the anorectic drug chlorphentermine or of the tricyclic antidepressants iprindole, imipramine and clomipramine