Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Zhuorong Li"'
Publikováno v:
Microbial Drug Resistance. 27:933-941
Polymyxin B and colistin (polymyxin E) are increasingly used as the last line of therapy for infections caused by multidrug-resistant (MDR) gram-negative pathogens. However, nephrotoxicity is still...
Autor:
Si-tu Xue, Yu-Huan Li, Zhao-Jin Zhong, Shuo Wu, A-Long Cui, Zhuorong Li, Jie Jin, Wen-Fang Sun
Publikováno v:
Drug Design, Development and Therapy. 14:3723-3729
Introduction Hepatitis B virus (HBV) is a global health concern that can cause acute and chronic liver diseases. Thus, there is an urgent need to research novel anti-HBV agents. Our previous reports show that N-phenylbenzamide derivatives exert broad
Autor:
Xinyue Hu, Xiujun Liu, Lianqi Sun, Yong-Su Zhen, Yi Li, Jie Jin, Yanping Li, Yu‐cheng Wang, Qingfang Miao, Rong Wang, Zhuorong Li, A-Long Cui
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 13, Iss 2, Pp 246-263 (2019)
Molecular Oncology, Vol 13, Iss 2, Pp 246-263 (2019)
Epidermal growth factor receptor (EGFR) is a rational target for cancer therapy, because its overexpression plays an important oncogenic role in a variety of solid tumors; however, EGFR-targeted antibody-drug conjugate (ADC) therapy for esophageal sq
Autor:
Chenxi Wang, Xinyue Hu, Zhuorong Li, Laixing Hu, Lianqi Sun, Yanbin Wu, Xiaofang Chen, Zhi Jiang
Publikováno v:
Bioorganic Chemistry. 99:103766
Optimization of IG-105 (1) on the carbazole ring provided five series of new carbazole sulfonamides derivatives, 7a–e, 8a–g, 9a–g, 10a–e, and 11a–g. All of the compounds were evaluated against HepG2, MCF-7, MIA PaCa-2, and Bel-7402 cells fo
Autor:
Jian-Dong Jiang, Xuefu You, Yang Chen, Huifang Guo, Xiukun Wang, Yan Gao, Hong Yi, Zhuorong Li, Xinxin Hu, Jie Jin, Qiyang He, Tongying Nie, A-Long Cui
Publikováno v:
Journal of medicinal chemistry. 61(5)
In this paper, 26 natural polymyxin components and a new derivative S2 were synthesized, and their differences in efficacy and toxicity have been investigated. Almost all of the synthesized components showed strong activity against both susceptible a
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 5, Iss 3, Pp 201-209 (2015)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
A series of novel N-phenylbenzamide and N-phenylacetophenone compounds were synthesized and evaluated for their antiviral activity against HCV and EV71 (strain SZ-98). The biological results showed that three compounds (23, 25 and 41) exhibited consi
Publikováno v:
Cancer Chemotherapy and Pharmacology. 75:773-782
To find novel potential and less toxic benquinone anamycin heat shock protein 90 (Hsp90) inhibitors as anticancer agents, a limited series of 17-substituted or 17,19-disubstituted 17-demethoxygeldanamycin analogs were synthesized and tested for anti-
Autor:
Lin-Lin Ma, Xingyue Ji, Si-tu Xue, Jian-Dong Jiang, Tian Zhang, Hui-Qiang Wang, Zhuorong Li, Zheng Guanghui, Bo Wang, Wei-ying He, Yu-Huan Li
Publikováno v:
Molecules, Vol 18, Iss 4, Pp 3789-3805 (2013)
Molecules
Molecules; Volume 18; Issue 4; Pages: 3789-3805
Molecules
Molecules; Volume 18; Issue 4; Pages: 3789-3805
A series of substituted aryl glycoside analogues of gastrodin have been identified as potential anti-influenza agents. The most potent inhibitor 1a exhibited moderate inhibitory activity against the A/Hanfang/359/95(H3N2) and A/FM/1/47(H1N1) strains
Autor:
Shuyi Si, Yueqin Zhang, Zhuorong Li, Xue Li, Hui-fang Guo, Zhaoyong Yang, Xiaobo He, Zong-ying Liu, Huayi Shao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4167-4170
A novel series of 1-(benzo[ b ]thiophen-2-yl)ethanone analogues were prepared and evaluated for enhancing BMP-2 expression. Compounds 1 – 5 , 7 , 8 , 12 , 13 and 16 , with upregulation rate values of 35.6%, 27.9%, 39.8%, 32.0%, 37.1%, 30.2%, 28.0%,
Autor:
Hong Yi, Xingyue Ji, Yue-chen Zhan, Zhuorong Li, Zheng Guanghui, Si-tu Xue, Zhen Wang, Jia-jia Shen
Publikováno v:
European journal of medicinal chemistry. 81
A novel class of small-molecule inhibitors of MDM2–p53 interaction with a (E)-3-benzylideneindolin-2-one scaffold was identified using an integrated virtual screening strategy that combined both pharmacophore- and structure-based approaches. The hi