Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Yueping Zhang"'
Autor:
R. Marcus Fancher, Hong Shen, Pawel D. Puszczalo, Shen-Jue Chen, Xue-Qing Chen, David J. Shuster, Cliff Chen, Zheng Yang, Yueping Zhang, Michael Sinz
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 375(1)
Organic anion-transporting polypeptide (OATP) 1B induction is an evolving mechanism of drug disposition and interaction. However, there are contradictory reports describing OATP1B expression in hepatocytes and liver biopsies after administration of a
Autor:
Hamza Kandoussi, T. Thanga Mariappan, Jianing Zeng, Vinay K. Holenarsipur, Yueping Zhang, Michael Sinz, Hong Shen
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(10)
Probenecid (PROB) is a clinical probe inhibitor of renal organic anion transporter (OAT) 1 and OAT3 that inhibits in vitro activity of hepatic drug transporters OATP1B1 and OATP1B3. It was hypothesized that PROB could potentially affect the dispositi
Autor:
W. Griffith Humphreys, Bridget L. Morse, Jamus MacGuire, Yurong Lai, Yueping Zhang, Hong Shen, Anthony M. Marino, Yue Zhao, Maxine Fox, Punit Marathe
Publikováno v:
The AAPS Journal. 19:1878-1889
In the present investigations, we evaluate in vitro hepatocyte uptake and partitioning for the prediction of in vivo clearance and liver partitioning. Monkeys were intravenously co-dosed with rosuvastatin and bosentan, substrates of the organic anion
Publikováno v:
Molecular pharmaceutics. 16(6)
Identification of a selective inhibitor of organic anion transporting polypeptide (OATP) 1B1 is critical in order to determine the contribution of OATP1B1-mediated uptake of investigational drugs into human hepatocytes for successful in vitro-to-in v
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 47(11)
Recent pharmacogenetic evidence indicates that hepatic organic cation transporter (OCT) 1 can serve as the locus of drug-drug interactions (DDIs) with significant pharmacokinetic and pharmacodynamic consequences. We examined the impact of preincubati
Autor:
Xiaomei Gu, W. Griffith Humphreys, Punit Marathe, Hong Cai, Jamus MacGuire, Hong Su, Maxine Fox, Yueping Zhang, Chiuwa E. Luk, Hong Shen, Yurong Lai, Lisa Zhang, Yue-Zhong Shu, Bridget L. Morse, Elizabeth A. Dierks
Publikováno v:
Drug Metabolism and Disposition. 43:1788-1794
Unbound plasma concentrations may not reflect those in target tissues, and there is a need for methods to predict tissue partitioning. Here, we investigate the unbound liver partitioning (Kpu,u) of rosuvastatin, a substrate of hepatic organic anion t
Autor:
Richard A. Westhouse, Nirmala Raghavan, Donglu Zhang, Weiping Zhao, Alban Allentoff, Ashok Kumar Gupta, W. Griffith Humphreys, Jinping Gan, Guoxiang Shen, Yueping Zhang, Robert M. Borzilleri, Oliver P. Flint, Jonathan L. Josephs, Punit Marathe, Janet Caceres-Cortes, Lifei Wang
Publikováno v:
Chemical Research in Toxicology. 25:556-571
A drug candidate, BMS-A ((N-(4-((1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl) 2-oxo-1,2-dihydropyridine- 3-carboxamide)), was associated with dose- and time-dependent vacuolar degeneration and necrosis of the adrenal cortex f
Autor:
Amrita Kamath, Yongmi An, John T. Hunt, Punit Marathe, Veeraswamy Manne, Zhen-Wei Cai, Donna D. Wei, John S. Sack, Robert J. Schmidt, Yueping Zhang, Robert M. Borzilleri, Kyoung S. Kim, Cornelius Lyndon A M, Gretchen M. Schroeder, David K. Williams, Xiao-Tao Chen, Joseph Fargnoli, Louis J. Lombardo, John S. Tokarski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3224-3229
A series of acylurea analogs derived from pyrrolopyridine and aminopyridine scaffolds were identified as potent inhibitors of Met kinase activity. The SAR at various positions of the two kinase scaffolds was investigated. These studies led to the dis
Autor:
Ligang Qian, Carl Thibeault, Amrita Kamath, Barri Wautlet, Alain Martel, George L. Trainor, Punit Marathe, Celia D’Arienzo, Benjamin J. Henley, Steven Mortillo, Donna D. Wei, Robert Jeyaseelan, Ravindra W. Tejwani, John T. Hunt, Louis J. Lombardo, Rejean Ruel, Yueping Zhang, Zhen-Wei Cai, Joseph Fargnoli, Arvind Mathur, Alexandre L'Heureux, Joel C. Barrish, Rajeev S. Bhide, George M. Derbin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2985-2989
We report herein a series of substituted N-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amines as inhibitors of vascular endothelial growth factor receptor-2 tyrosine kinase. Through structure–activity relationship studies, biochem
Autor:
Ramaswamy A. Iyer, Yong-Hae Han, Tongtong Liu, Murali K. Matta, Zheng Yang, Yurong Lai, Yueping Zhang, A. David Rodrigues, Michael T. Furlong, Prashant Kole, Sandhya Mandlekar, Siva Prasad Putluru, Punit Marathe
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 44(3)
Although the metabolism and disposition of diclofenac (DF) has been studied extensively, information regarding the plasma levels of its acyl-β-d-glucuronide (DF-AG), a major metabolite, in human subjects is limited. Therefore, DF-AG concentrations w