Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mingshan Niu"'
Autor:
Ting Pan, Lingling Yin, Huanxin Zhang, Kailin Xu, Zhenyu Li, Ninghan Zhang, Qing-Yun Wu, Shengyun Zhu, Rong Wang, Jiawen Xu, Linyan Xu, Xuejiao Liu, Mingshan Niu, Yao Yao
Publikováno v:
Journal of Molecular Medicine. 99:1447-1458
The NF-κB signaling pathway is an important downstream pathway of oncogenic Notch1 in T cell acute lymphoblastic leukemia (T-ALL) cells. However, the molecular mechanisms underlying the cascade activation of Notch1 in T-ALL cells are poorly understo
Autor:
Di Zhou, Yulong Chong, Yifeng Wang, Huan Li, Lin Shi, Yiming Tu, Xuejiao Liu, Xu Zhang, Mingshan Niu, Guanzheng Liu, Rutong Yu, Shangfeng Gao, Sijin Wu
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-12 (2020)
Cancer Cell International
Cancer Cell International
BackgroundActivation of nuclear factor-kappa B (NF-κΒ) through DNA damage is one of the causes of tumor cell resistance to radiotherapy. Chromosome region 1 (CRM1) regulates tumor cell proliferation, drug resistance, and radiation resistance by reg
Autor:
Runqiu Wu, Wanhong Zhang, Rutong Yu, Mingshan Niu, Jiefeng Yu, Guanzheng Liu, Xuejiao Liu, Huan Li, Xu Zhang
Publikováno v:
Journal of Cellular and Molecular Medicine
Glioblastoma multiforme (GBM), a fatal brain tumour with no available targeted therapies, has a poor prognosis. At present, radiotherapy is one of the main methods to treat glioma, but it leads to an obvious increase in inflammatory factors in the tu
Autor:
Jie Wang, Rutong Yu, Chenglong Yue, Mingshan Niu, Qiyu Cao, Xiangyu Chen, Shangfeng Gao, Shengsheng Li, Lin Shi, Qianqian Shan, Huan Li, Xuejiao Liu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Glioblastoma (GBM) is a fatal brain tumor, lacking effective treatment. Epidermal growth factor receptor (EGFR) is recognized as an attractive target for GBM treatment. However, GBMs have very poor responses to the first- and second-genera
Autor:
Robert H. Weber, Dominique Garrison, James S. Blachly, Mingshan Niu, Daelynn R. Buelow, Megan E. Zavorka Thomas, Shelley Orwick, Steve L. Warner, Eric D. Eisenmann, Lindsey T. Brinton, Emily Stahl, Jae Yoon Jeon, Rosa Lapalombella, Erin Hertlein, John C. Byrd, Clifford J. Whatcott, Kevin M. Huang, Sharyn D. Baker, Bhavana Bhatnagar, Bridget Carmichael
Publikováno v:
JCI Insight, Vol 5, Iss 23 (2020)
JCI Insight
JCI Insight
Effective treatment for AML is challenging due to the presence of clonal heterogeneity and the evolution of polyclonal drug resistance. Here, we report that TP-0903 has potent activity against protein kinases related to STAT, AKT, and ERK signaling,
Autor:
Ting Zhou, Qian Qian Shan, Yiming Tu, Mingshan Niu, Chenglong Yue, Xuejiao Liu, Lei Hua, Peng Xie, Rutong Yu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 36, Iss 1, Pp 1-11 (2017)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Malignant glioma is the most common primary brain tumor in adults and has a poor prognosis. However, there are no effective targeted therapies for glioma patients. Thus, the development of novel targeted therapeutics for glioma is urgently
Publikováno v:
Traffic. 14:1042-1052
Curcumin is the major constituent of turmeric plant, an ancient spice widely used in Indian cuisine and traditional herbal medicine. Recently, the potential medical use of curcumin as anti-cancer and anti-inflammatory agent has set off an upsurge in
Publikováno v:
The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
In the present work, we studied the structure-activity relationship (SAR) of tautomycetin (TMC) and its derivatives. Further, we demonstrated the correlation between the immunosuppressive fuction, anticancer activity and protein phosphatase type 1 (P
Autor:
Xuejiao Liu, Wei Cai, Shangfeng Gao, Rutong Yu, Huize Liu, Qiong Shi, Xiuping Zhou, Yulong Chong, Wenqiang Hu, Mingshan Niu
Publikováno v:
Journal of Pharmacological Sciences, Vol 128, Iss 3, Pp 131-136 (2015)
Plumbagin is a natural compound that is isolated from the root of the medicinal plant Plumbago zeylanica L. Based on a previous in vitro study performed by our group, which demonstrated the effectiveness of plumbagin against glioma cells, we further
Autor:
Xuejiao Liu, Xiaoyu Xu, Kailin Xu, Mingshan Niu, Feng Zhu, Lingyu Zeng, Yangling Shen, Yao Yao, Jianlin Qiao
Publikováno v:
Chemico-biological interactions. 237
Piperlongumine is a natural compound recently identified to be toxic selectively to tumor cells in vitro and in vivo. However, the molecular mechanism underlying its anti-tumor action still remains unclear. In this report, we describe another novel m