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pro vyhledávání: '"Bruce A. Littlefield"'
Eribulin mesylate (eribulin) is a synthetic analogue of the marine-sponge natural product halichondrin B. Eribulin exhibits potent antiproliferative activities against a variety of human cancer cell types in vitro and in vivo, and is used for the tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a030d57633f34a0f89fcfe21e08c8a1b
https://lirias.kuleuven.be/handle/123456789/636778
https://lirias.kuleuven.be/handle/123456789/636778
Autor:
Boris M. Seletsky, Karen TenDyke, Sean Eckley, Bruce A. Littlefield, Huiming Zhang, Hong Du, Carlson Eric, Wanjun Zheng, Yimin Jiang, Sridhar Narayan, Murray J. Towle, Yongbo Hu, Edgar Schuck, Krista Condon, Vipul Kumar, Hongsheng Cheng, Bryan M. Lewis, Philip Saxton, Melvin J. Yu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1639-1643
Novel second generation analogs of eribulin mesylate, a tubulin agent recently approved for the treatment of breast cancer, are reported. Our recent efforts have focused on expanding the target indications for this class of compounds to other tumor t
Publikováno v:
Molecular Cancer Therapeutics. 17:B191-B191
Eribulin is a synthetic analog of the marine sponge natural product halichondrin B. Its clinical formulation is currently approved in numerous countries for treating certain patients with advanced breast cancer or advanced liposarcoma. Eribulin’s a
Autor:
Charles-André Lemelin, Boris M. Seletsky, Kimberley K. Aalfs, Paul J. Lydon, Davis Heather, Yoshito Kishi, Kathleen A. Salvato, Bruce A. Littlefield, Lynda Tremblay, Murray J. Towle, Charles E. Chase, Yongchun Shen, Lori A. Singer, Melvin J. Yu, Wanjun Zheng, Bruce F. Wels, Monica Palme
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5551-5554
Structurally simplified macrocyclic ketone analogues of halichondrin B were prepared by total synthesis and found to retain the potent cell growth inhibitory activity in vitro, stability in mouse serum, and in vivo efficacy of the natural product.
Autor:
Edgar Schuck, Bruce A. Littlefield, Sean Eckley, Wanjun Zheng, Hongsheng Cheng, Huiming Zhang, Melvin J. Yu, Hong Du, Yimin Jiang, Carlson Eric, Yongbo Hu, Karen TenDyke, Murray J. Towle, Bryan M. Lewis, Philip Saxton, Boris M. Seletsky, Vipul Kumar, Krista Condon, Sridhar Narayan
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(6)
Eribulin mesylate is a newly approved treatment for locally advanced and metastatic breast cancer. We targeted oral bioavailability and efficacy against multidrug resistant (MDR) tumors for further work. The design, synthesis and evaluation of novel
Autor:
Xiaojie Zhu, Bruce F. Wels, Bruce A. Littlefield, Yoshito Kishi, Bryan M. Lewis, Boris M. Seletsky, Murray J. Towle, Wanjun Zheng, Melvin J. Yu, Kathleen A. Salvato, Kimberley K. Aalfs
Publikováno v:
Cancer research. 71(2)
Eribulin (E7389), a mechanistically unique microtubule inhibitor in phase III clinical trials for cancer, exhibits superior efficacy in vivo relative to the more potent compound ER-076349, a fact not explained by different pharmacokinetic properties.
Autor:
Junke Liu, Francis G. Fang, Silvio Campagna, Edward M. Suh, Veronique Marceau, Ye Yao, James J. Kowalczyk, Shawn Schiller, Hongsheng Cheng, Galina Kuznetsov, Karen TenDyke, Bruce A. Littlefield, Hu Yang, Murray J. Towle, Christina J. Shaffer, Mark Spyvee, Joanne Marsh, Boris M. Seletsky
Publikováno v:
Molecular cancer therapeutics. 8(10)
E7974 is a synthetic analogue of the marine sponge natural product hemiasterlin. Here, we show that E7974, such as parental hemiasterlin, acts via a tubulin-based antimitotic mechanism. E7974 inhibits polymerization of purified tubulin in vitro with
Autor:
Karen TenDyke, Roch Boivin, Hong Du, Sergei Agoulnik, Daniel Romo, Yuan Wang, Zhihong Chen, Lana Parent, Huiming Zhang, Nanding Zhao, Bruce A. Littlefield, Jue-lon Shie, Yimin Jiang, Natalie C. Twine, Lori Rudolph-Owen, Murray J. Towle, Joanne Marsh, Qunli Xu, Junke Liu, Galina Kuznetsov
Publikováno v:
Molecular cancer therapeutics. 8(5)
We report here that des-methyl, des-amino pateamine A (DMDA-PatA), a structurally simplified analogue of the marine natural product pateamine A, has potent antiproliferative activity against a wide variety of human cancer cell lines while showing rel
Publikováno v:
Endocrinology. 117:412-414
Steroid receptor complexes bind to specific nuclear acceptor sites on chromatin to induce alterations in gene expression. This paper describes many factors regulating the nuclear binding of the avian oviduct progesterone receptor. Some of these facto