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Publikováno v:
Acta Pharmacologica et Toxicologica. 58:61-70
A number of potential neuroleptic drugs of the substituted benzamide type have been compared with some reference neuroleptic drugs regarding their affinities for rat brain receptors using in vitro receptor binding techniques. The effects on dopamine-
Publikováno v:
Acta Pharmacologica et Toxicologica. 55:391-397
D2343 is a compound with about the same beta 2-adrenoceptor-agonist effect as terbutaline and exhibiting in addition an alpha 1-receptor inhibitory activity. D2343 has been compared to the beta 2-agonist terbutaline on oestrogenized uterine preparati
Autor:
E. Malta
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. :236-243
The concentration-effect curve for the relaxant effects of glyceryl trinitrate (GTN) in rat aortic rings consisted of two phases with IC50 values of 0.1 microM for Phase I and 14 microM for Phase II. Incubation of tissues with oxyhaemoglobin or the i
Publikováno v:
Agents and Actions. 40:28-36
The mechanisms of vancomycin (VCM)-induced histamine release were studied with rat peritoneal mast cells. VCM (1 x 10(-3) M) released histamine from the isolated mast cells in a dose-dependent and noncytotoxic manner. In the absence of extracellular
Autor:
Zoheir A. Damanhouri, Osama S. Tayeb
Publikováno v:
Pharmacological Research. 26:93-100
Change in body temperature is reported to induce changes in muscle contraction by unconfirmed mechanisms. Therefore, the changes in isolated rat ileal muscle contractions at different surrounding temperatures were studied. The contraction was decreas
Publikováno v:
Journal of Autonomic Pharmacology. 12:245-252
1. The effects of (1) nerve stimulation (NS, 0.5 ms, 1-16 Hz, supramaximal voltage, 20 s) upon vasoconstriction, as measured by changes in perfusion pressure and (2) exogenously added co-transmitters noradrenaline (NA) and alpha, beta,-methylene ATP
Publikováno v:
Psychopharmacology. 108:320-326
The Ki values for etoperidone, trazodone and MCPP (m-chlorophenylpiperazine dihydrochloride) at 5-HT1A sites (using rat cerebral cortical synaptosomes and [3H]8-OH-DPAT) were determined to be 20.2, 23.6 and 18.9 nM, respectively. In an effort to eluc
Autor:
Andrew M. Ellis, Susan J. Coker
Publikováno v:
European Journal of Pharmacology. 219:97-104
The effects of certain 5-HT receptor antagonists were examined on ischaemia-induced and reperfusion-induced arrhythmias, on ex vivo platelet aggregation and on isolated cardiac muscle. Methiothepin (1 mg kg-1) reduced the total number of ischaemia-in
Publikováno v:
Journal of Cardiovascular Pharmacology. 19:958-965
Isolated tail arteries from Wistar rats, prelabeled with [3H]norepinephrine (NE) were subjected to electrical field stimulation (24 pulses at 0.4 Hz and 200 mA). Both NE release and vasoconstriction were measured in parallel. The selective alpha 2-ad
Autor:
Th. Noack, P.-O. Andersson, Michael G. Wyllie, Arthur H. Weston, P.M. Greengrass, Petra Deitmer, T. Morita, David N. Criddle, Gillian Edwards
Publikováno v:
British Journal of Pharmacology. 106:17-24
1. In whole portal veins, ciclazindol (0.3-10 microM) increased the amplitude and duration, but decreased the frequency of spontaneous contractions. Glibenclamide (0.3-10 microM) produced a small increase in contraction amplitude and duration with a