Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Diwakar Davar"'
Autor:
Jennifer Bordeaux, Dustin McCurry, Arivarasan Karunamurthy, Lisa H. Butterfield, Rogerio I. Neves, Anil Pahuja, Matthew P. Holtzman, Beiru Chen, Jehovana Orozco Bender, Ahmad A. Tarhini, Yan Zang, Ju Young Kim, John M. Kirkwood, Yan Lin, Cindy Sander, Joseph J. Skitzki, IlaSri B. Summit, Marc S. Ernstoff, Christian Laing, Joseph J. Drabick, Yana G. Najjar, Huang Lin, Jennifer Tsau, Ghanashyam Sarikonda, Igor Puzanov, Hassane M. Zarour, Zeni Alfonso, Amy Rose, James F. Pingpank, Diwakar Davar
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 27, iss 15
Purpose:Neoadjuvant immunotherapy may improve the clinical outcome of regionally advanced operable melanoma and allows for rapid clinical and pathologic assessment of response. We examined neoadjuvant pembrolizumab and high-dose IFNα-2b (HDI) therap
Publikováno v:
OncoTargets and Therapy. 13:10039-10061
Toll-like receptor 9 (TLR9) is a pattern recognition receptor that is predominantly located intracellularly in immune cells, including dendritic cells, macrophages, natural killer cells, and other antigen-presenting cells (APC). The primary ligands f
Autor:
Yana G. Najjar, Diwakar Davar, Xi Yang, Saba Shaikh, Greg M. Delgoffe, Yan Zang, Amy Rose, John M. Kirkwood, Hassane M. Zarour, Hong Wang, Jason J. Luke, Cindy Sander
Publikováno v:
Regular and young investigator award abstracts.
Background Immunotherapy has changed the treatment landscape for melanoma, although many patients (pts) do not respond to treatment. While there are likely multiple mechanisms of resistance at play, one key mechanism is the generation of an immunosup
Autor:
Hassane M. Zarour, Diwakar Davar
Publikováno v:
Biomarkers for Immunotherapy of Cancer ISBN: 9781493997725
Methods Mol Biol
Methods Mol Biol
Tumor development is characterized by the accumulation of mutational and epigenetic changes that transform normal cells and survival pathways into self-sustaining cells capable of untrammeled growth. Although multiple modalities including surgery, ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96bab0394177e85f73e465a3037e92e
https://doi.org/10.1007/978-1-4939-9773-2_2
https://doi.org/10.1007/978-1-4939-9773-2_2
Autor:
Hassane M. Zarour, Richelle DeBlasio, Marc Schwartz, Stephanie Prescott, Ivan Vujkovic-Cvijin, Amy Rose, Marie Vétizou, Scarlett J. Ernst, Jonathan H. Badger, Howard M. Dubner, Hong Wang, Yasmine Belkaid, John M. Kirkwood, Ascharya K. Balaji, Amiran Dzutsev, Diwakar Davar, Yana G. Najjar, Quanquan Ding, Raquel Galvão Figueredo Costa, Joe-Marc Chauvin, Shuowen Zhang, Carmine Menna, Amir A. Borhani, Giorgio Trinchieri, John A. McCulloch, Bochra Zidi, Richard R. Rodrigues, Ornella Pagliano, Miriam R. Fernandes, Andrey Morgun, Robert M. Morrison, Alicia M. Cole
Publikováno v:
Cancer Research. 81:LB062-LB062
Background: Monoclonal antibodies (mAb) targeting the programmed cell death protein 1 (PD-1) receptor provide durable long-term benefit in a subset of patients (pts) with advanced melanoma with response rates of 35-42% and 4-year progression-free sur
Autor:
Alan J. Korman, Diwakar Davar, Cindy Sander, Mignane B. Ka, John M. Kirkwood, Julien Fourcade, Hassane M. Zarour, Hong Wang, Ornella Pagliano, Zhaojun Sun, Joe-Marc Chauvin, Sofiane Saada, Carmine Menna, Rada Amin
CD4+ Tregs impede T cell responses to tumors. They express multiple inhibitory receptors that support their suppressive functions, including T cell Ig and ITIM domain (TIGIT). In melanoma patients, we show that Tregs exhibit increased TIGIT expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b285657653ceffba41ce16464236057
https://europepmc.org/articles/PMC6124410/
https://europepmc.org/articles/PMC6124410/
Publikováno v:
The American Cancer Society's Principles of Oncology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12e2acaef0f2dee38af6288772eac44f
https://doi.org/10.1002/9781119468868.ch20
https://doi.org/10.1002/9781119468868.ch20
Autor:
Weijing Sun, Diwakar Davar
Publikováno v:
Journal of Cancer Therapy. :622-646
Gastrointestinal (GI) malignancies (esophageal, gastric, pancreatic, intra- and extra-biliary ductal, hepatocellular, and colorectal cancers) are an important cause of cancer incidence and mortality in the US and globally. GI cancers account for 15.4
Autor:
Diwakar Davar, John M. Kirkwood
Publikováno v:
JAMA Oncology. 5:942
Autor:
Amit Hemadri, Yana G. Najjar, Cindy Sander, Hassane M. Zarour, John M. Kirkwood, Amy Rose, Yan Lin, Huang Lin, Diwakar Davar
Publikováno v:
Journal of Clinical Oncology. 37:9572-9572
9572 Background: Retrospective studies suggest that various med could dichotomous effects in regards to immunotherapy. These include adverse (antibiotics) and positive (aspirin, beta-blockers) influences. To evaluate potential additive or detrimental