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Publikováno v:
OncoTargets and Therapy. 13:10039-10061
Toll-like receptor 9 (TLR9) is a pattern recognition receptor that is predominantly located intracellularly in immune cells, including dendritic cells, macrophages, natural killer cells, and other antigen-presenting cells (APC). The primary ligands f
Autor:
John M. Kirkwood, Diwakar Davar
Publikováno v:
Expert Opin Investig Drugs
INTRODUCTION: Therapies targeting immune checkpoints (CTLA-4) and the MAP kinase signaling pathway (RAS/RAF/MEK/ERK) have transformed the treatment of advanced melanoma in the past year. Agents aimed at other therapeutic targets of interest are being