Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Yuan, K."'
Autor:
Roberto Meza-Romero, Jeffery L. Mooney, Halina Offner, Yuan K. Chou, Arthur A. Vandenbark, Chunhe Wang, Gregory G. Burrows, Jianya Huan
Publikováno v:
The Journal of Immunology. 171:1934-1940
Recombinant TCR ligands (RTLs) consisting of covalently linked α1 and β1 domains of MHC class II molecules tethered to specific antigenic peptides represent minimal TCR ligands. In a previous study we reported that the rat RTL201 construct, contain
Autor:
Arthur A. Vandenbark, Tohru Yoshioka, Yuan K. Chou, Joseph Kim, Masayuki Ikeda, Halina Offner, Gregory G. Burrows, Dennis Bourdette, Justin W. Chang, Nicole Culbertson, Chunhe Wang, Charles N. Allen, Deborah A. Lewinsohn, David M. Lewinsohn, Thomas P. Finn
Publikováno v:
The Journal of Immunology. 167:4386-4395
Understanding the process of inducing T cell activation has been hampered by the complex interactions between APC and inflammatory Th1 cells. To dissociate Ag-specific signaling through the TCR from costimulatory signaling, rTCR ligands (RTL) contain
Autor:
David Barnes, Dennis Bourdette, Arthur A. Vandenbark, Ruth H. Whitham, Tom Finn, Halina Offner, Steven D. Miller, Johnan Kaleeba, Ian Robey, Yuan K. Chou, Bruce F. Bebo
Publikováno v:
International Immunology. 12:57-66
Antigen-coupled antigen-presenting cells (APC) serve as potent tolerogens for inhibiting immune responses in vivo and in vitro, apparently by providing an antigen-specific signal through the TCR in the absence of co-stimulation. Although this approac
Autor:
Dennis N. Bourdette, Yuan K. Chou, Ruth H. Whitham, Jane Buckner, Hi Jong Kwon, Gerald T. Nepom, Abigail Buenafe, Shelley A. Cooper, Mark Allegretta, George A. Hashim, Halina Offner, Arthur A. Vandenbark
Publikováno v:
The Journal of Immunology. 161:1034-1044
Vaccination with synthetic TCR peptides from the BV5S2 complementarity-determining region 2 (CDR2) can boost significantly the frequency of circulating CD4+ peptide-specific Th2 cells in multiple sclerosis (MS) patients, with an associated decrease i
Publikováno v:
Cytokine. 63(1)
Differentiation of naïve CD4(+) T cells has been considered to be an irreversible event and, in particular, the plasticity is believed to be completely lost in Th1 subset in vitro after multiple stimulations. However, here we demonstrate that highly
Autor:
Roberto Meza-Romero, Rony Dahan, Jianya Huan, Halina Offner, Yuan K. Chou, Abigail C. Buenafe, Gregory G. Burrows, Gil Benedek, Jeffery L. Mooney, Arthur A. Vandenbark, Yoram Reiter, Shayne Andrew
Treatment with partial (p)MHC class II-β1α1 constructs (also referred to as recombinant T-cell receptor ligands - RTL) linked to antigenic peptides can induce T-cell tolerance, inhibit recruitment of inflammatory cells and reverse autoimmune diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e707742936510398787c7c718a855033
https://europepmc.org/articles/PMC3789252/
https://europepmc.org/articles/PMC3789252/
Autor:
Jeanette Atherton, Yuan K. Chou, Dennis Bourdette, Ruth Whithman, Richard E. Jones, George A. Hashim, Halina Offner, Arthur A. Vandenbark
Publikováno v:
Journal of Neuroimmunology. 49:45-50
We investigated whether myelin basic protein (MBP)-reactive T cells from multiple sclerosis (MS) patients can recognize mouse MBP since this is an expected requirement for the transfer of experimental autoimmune encephalomyelitis (EAE) into severe co
Autor:
Halina Offner, Ruth H. Whitham, Yuan K. Chou, George A. Hashim, Arthur A. Vandenbark, Dennis Bourdette, Karuturi Satyanarayana
Publikováno v:
Journal of Neuroimmunology. 44:57-67
Recent evidence supports the possible involvement of myelin basic protein (BP) as one of the target autoantigens in multiple sclerosis (MS), including elevated frequencies of MS blood and cerebrospinal fluid (CSF) T cells, and the presence in MS plaq
Autor:
Paula Henderikx, Halina Offner, Richard E. Jones, Arthur A. Vandenbark, Yuan K. Chou, Brian L. Kotzin, George A. Hashim
Publikováno v:
Autoimmunity. 14:111-119
Normal human CD8+ T cell clones were co-isolated from the same culture wells as CD4+ T effector cell clones specific for myelin basic protein (MBP). Microcultures from which the CD8+ clones were isolated initially proliferated weakly to whole MBP and
Autor:
Dennis Bourdette, Marci Agotsch, Arthur A. Vandenbark, Jianya Huan, Richard Bartholomew, Dorian LaTocha, Ruth H. Whitham, Halina Offner, Jesus Lovera, Vijayshree Yadav, Georgia Theofan, Michele Mass, Nicole Culbertson, June Milano, Yuan K. Chou
Publikováno v:
Immunology. 123(1)
Therapeutic vaccination using T-cell receptor (TCR) peptides from V genes commonly expressed by potentially pathogenic T cells remains an approach of interest for treatment of multiple sclerosis (MS) and other autoimmune diseases. We developed a triv