Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yongzhi Cui"'
Autor:
Massimo Fantini, Philip M. Arlen, Christina M. Annunziata, Kwong Y. Tsang, Olga Saric, Andrew Bristol, Sharon Mavroukakis, Alexander Dubeykovskiy, Justin M. David, Yongzhi Cui
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 8 (2018)
Frontiers in Immunology, Vol 8 (2018)
NEO-201 is a novel humanized IgG1 monoclonal antibody that was derived from an immunogenic preparation of tumor-associated antigens from pooled allogeneic colon tumor tissue extracts. It was found to react against a variety of cultured human carcinom
Autor:
Marianna Sabatino, Curt I. Civin, Nga Voong, Yongzhi Cui, Sebastien Morisot, Crystal L. Mackall, Dave Stroncek, Bruce L. Levine, Hua Zhang, Alan S. Wayne
Publikováno v:
Journal of Immunotherapy. 34:187-195
Natural killer (NK) cells can mediate potent antitumor effects, but factors regulating the efficiency of tumor lysis remain unclear. Studies in allogeneic stem cell transplantation highlight an important role for killer cell immunoglobulin-like recep
Autor:
Su Young Kim, Melinda S. Merchant, Sema Kurtulus, Yongzhi Cui, Martin Guimond, Hua Zhang, David J. Grindler, Lothar Hennighausen, Crystal L. Mackall, Risu Na, Batu Erman, Polly Matzinger, Ryan D Murphy, Rachelle G. Veenstra
Publikováno v:
Nature immunology
Interleukin 7 (IL-7) and T cell antigen receptor signals have been proposed to be the main drivers of homeostatic T cell proliferation. However, it is not known why CD4(+) T cells undergo less-efficient homeostatic proliferation than CD8(+) T cells d
Autor:
Warren J. Leonard, Kairong Cui, Wei Liao, Dustin E. Schones, Tae-Young Roh, Keji Zhao, Yongzhi Cui, Jangsuk Oh
Publikováno v:
Nature immunology
T helper type 2 (T(H)2) cells are essential for humoral immunity and host defense. Interleukin 4 (IL-4) drives T(H)2 differentiation and IL-2 augments the accessibility of Il4 chromatin. Here we demonstrate that IL-2, by inducing binding of STAT5 to
Autor:
Jung-Hyun Park, Stanley Adoro, Terry Guinter, Batu Erman, Amala S Alag, Marta Catalfamo, Motoko Y Kimura, Yongzhi Cui, Philip J Lucas, Ronald E Gress, Masato Kubo, Lothar Hennighausen, Lionel Feigenbaum, Alfred Singer
Publikováno v:
Nature immunology. 11(3)
Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor alpha-chain (CD25) molecules. When CD4+ cell suspensions prepared from BALB/c nu/+ mice lymph nodes and spleens were
Publikováno v:
The Journal of Immunology. 192:205.11-205.11
Genetically engineered T-cells expressing chimeric antigen receptors directly target cell surface antigens on tumor cells. CARs have shown remarkable activity in clinical trials for hematologic malignancies but remain unproven for the treatment of so
Publikováno v:
The Journal of Immunology. 186:48.25-48.25
Survivin has been considered a potential tumor antigen due to high expression in most cancers and limited expression in normal tissues. To explore the potential for survivin reactive TCRs to mediate antitumor effects in mice, we generated several fou
Publikováno v:
The Journal of Immunology. 184:101.19-101.19
Cell based immunity is driven by CD8+ cytotoxic T cells bearing TCR that recognize specific tumor-associated peptides bound to class I MHC molecules. Survivin, an inhibitor of apoptosis protein (IAP), is a tumor-associated antigen that is widely expr