Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Aaron W. Michels"'
Autor:
Maki Nakayama, Aaron W. Michels
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
T cell receptors (TCRs) are unique markers that define antigen specificity for a given T cell. With the evolution of sequencing and computational analysis technologies, TCRs are now prime candidates for the development of next-generation non-cell bas
Autor:
Anita Hohenstein, Laurent Gapin, Niyun Jin, Aaron W. Michels, Maki Nakayama, Howard W. Davidson, Laurie G. Landry, Frances Crawford, John W. Kappler, Megan E DeNicola, Theodore Williams, Sally C. Kent, Harsha Krovi
Publikováno v:
J Immunol Methods
Immortalized T cells such as T cell hybridomas, transfectomas, and transductants are useful tools to study tri-molecular complexes consisting of peptide, MHC, and T cell receptor (TCR) molecules. These cells have been utilized for antigen discovery s
Autor:
Sarah E. Mann, Zhicheng Zhou, Laurie G. Landry, Amanda M. Anderson, Aimon K. Alkanani, Jeremy Fischer, Mark Peakman, Roberto Mallone, Kristen Campbell, Aaron W. Michels, Maki Nakayama
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
Recent advancements in single cell sequencing technologies allow for identification of numerous immune-receptors expressed by T cells such as tumor-specific and autoimmune T cells. Determining antigen specificity of those cells holds immense therapeu
Autor:
Maki Nakayama, Aaron W. Michels
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, Vol 10 (2019)
Type 1 diabetes, the immune mediated form of diabetes, represents a prototypical organ specific autoimmune disease in that insulin producing pancreatic islets are specifically targeted by T cells. The disease is now predictable in humans with the mea
Autor:
Angela M Mitchell, Aimon K Alkanani, Kristen A McDaniel, Laurie G Landry, Maki Nakayama, Aaron W Michels
Publikováno v:
The Journal of Immunology. 204:224.21-224.21
The major genetic determinant in susceptibility or protection from many autoimmune diseases resides in the human leukocyte antigen (HLA) region. Specific class II alleles (e.g., HLA-DQ8) increase the risk for developing type 1 diabetes (T1D), a proto
Autor:
Todd M. Brusko, Amanda L. Posgai, Brittney N. Newby, Howard R. Seay, Aaron W. Michels, Filipa Botelho Moniz, Clayton E. Mathews, Jeffrey A. Bluestone, Wen-I Yeh
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The ability to alter antigen specificity by T-cell receptor (TCR) or chimeric antigen receptor (CAR) gene transfer has facilitated personalized cellular immune therapies in cancer. Inversely, this approach can be harnessed in autoimmune settings to a
Autor:
Aaron W. Michels
Publikováno v:
Clinical Immunology. 149:339-344
Class II major histocompatibility molecules (MHC) confer disease risk for multiple autoimmune disorders including type 1 diabetes. The interaction between the components of the trimolecular complex (CD4(+) T cell receptors, self-peptide, and MHC clas
Autor:
Aaron W. Michels, John S. Kaddis, Ezio Bonifacio, Mark A. Atkinson, Alberto Pugliese, Liping Yu, Desmond A. Schatz, Emily L. Montgomery, Clive Wasserfall, Concepcion Nierras, Roberto Gianani
Publikováno v:
Clinical and experimental immunology. 185(1)
Summary The Network for Pancreatic Organ donors with Diabetes (nPOD) programme was developed in response to an unmet research need for human pancreatic tissue obtained from individuals with type 1 diabetes mellitus and people at increased risk [i.e.
Autor:
Aaron W. Michels, George S. Eisenbarth
Publikováno v:
Seminars in Immunology. 23:214-219
Type 1 diabetes (T1D) is a chronic autoimmune disease that results in the specific immune destruction of insulin producing beta cells. Currently there is no cure for T1D and treatment for the disease consists of lifelong administration of insulin. Im
Autor:
Aaron W. Michels, David A. Ostrov
Publikováno v:
The Journal of allergy and clinical immunology. 136(2)
Adverse drug reactions (ADRs) are commonplace and occur when a drug binds to its intended pharmacological target (Type A ADR) or an unintended target (Type B ADR). Immunologically mediated Type B ADRs, such as drug hypersensitivity syndrome, drug rea