Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Glenn Dranoff"'
Autor:
Lina Driouk, Joanina K. Gicobi, Yusuke Kamihara, Kayleigh Rutherford, Glenn Dranoff, Jerome Ritz, Susanne H. C. Baumeister
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
CAR T cell approaches to effectively target AML and T-ALL without off-tumor effects on healthy myeloid or T cell compartments respectively are an unmet medical need. NKG2D-ligands are a promising target given their absence on healthy cells and surfac
Autor:
Venkat S. Malladi, Chad V. Pecot, Sangeetha Palakurthi, Juan J. Miret, Mingrui Zhu, Kwok-Kin Wong, Esra A. Akbay, Wei Huang, Shohei Koyama, Yujiro Naito, William F. Walker, Glenn Dranoff, Yvonne Y. Li, Min Wu, Peter S. Hammerman, Paul Kirschmeier
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Background Tumor orchestrated metabolic changes in the microenvironment limit generation of anti-tumor immune responses. Availability of arginine, a semi-essential amino acid, is critical for lymphocyte proliferation and function. Levels of arginine
Autor:
Seth Ettenberg, Nicholas S. Wilson, Sarah M. Rue, Maurice Windman, Yannick Bulliard, Jennifer Brogdon, Glenn Dranoff, Rose Jolicoeur, Deborah A. Knee
Publikováno v:
The Journal of Experimental Medicine
Antibodies that coengage activating FcγRs expressed by tumor-associated leukocytes facilitate the selective elimination of intratumoral T cells.
Fc γ receptor (FcγR) coengagement can facilitate antibody-mediated receptor activation in target
Fc γ receptor (FcγR) coengagement can facilitate antibody-mediated receptor activation in target
Publikováno v:
Annual review of immunology. 34
The immune system is capable of recognizing tumors and eliminates many early malignant cells. However, tumors evolve to evade immune attack, and the tumor microenvironment is immunosuppressive. Immune responses are regulated by a number of immunologi
Autor:
José M. Casasnovas, David M. Dorfman, Arlene H. Sharpe, Piia Karisola, Manish J. Butte, Gerardo G. Kaplan, Gordon J. Freeman, Rosemarie H. DeKruyff, Dale T. Umetsu, Masahisa Jinushi, Victor Pena-Cruz, Susumu Ito, Sarah E. Umetsu, Haruo Nagumo, Baogong Zhu, Norimoto Kobayashi, Irene Chernova, Glenn Dranoff
Publikováno v:
Immunity. 27(6):927-940
The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. Both TIM-4, expressed on human and mouse macrophages and dendritic cells, and TIM-1 specifically bind to phosphatidylserine (PS) on the surface of apoptotic cell
Autor:
Matthew Vanneman, Weibo Li, Glenn Dranoff, Girija Goyal, Dobrin Draganov, Richard S. Blumberg, Brant Firestone, Nir Hacohen, Donna Neuberg, Michael Dougan, Joanna Slisz, Dale Porter, Stephanie K. Dougan, Leigh Zawel
Publikováno v:
The Journal of Experimental Medicine
The inhibitor of apoptosis proteins (IAPs) have recently been shown to modulate nuclear factor κB (NF-κB) signaling downstream of tumor necrosis factor (TNF) family receptors, positioning them as essential survival factors in several cancer cell li