Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Yin, Lu"'
Autor:
Xiaoju Xu, Xu Xu, Yanping Hao, Xialin Zhu, Jian Lu, Xingnan Ouyang, Yin Lu, Xi Huang, Yang Li, Jiaying Wang, Xu Shen
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101617- (2020)
Summary: Diabetic peripheral neuropathy (DPN) is a common diabetic complication and has yet no efficient medication. Here, we report that antispasmodic drug drofenine (Dfe) blocks Kv2.1 and ameliorates DPN-like pathology in diabetic mice. The underly
Externí odkaz:
https://doaj.org/article/9d835a50cf9941f3a04af23139ae18a3
Autor:
Weiwei, Zheng, Cheng, Qian, Yu, Tang, Chunmei, Yang, Yueke, Zhou, Peiliang, Shen, Wenxing, Chen, Suyun, Yu, Zhonghong, Wei, Aiyun, Wang, Yin, Lu, Yang, Zhao
Publikováno v:
Frontiers in Immunology. 13
Immunotherapy has been recognized as an effective and important therapeutic modality for multiple types of cancer. Nevertheless, it has been increasing recognized that clinical benefits of immunotherapy are less than expected as evidenced by the fact
Publikováno v:
International immunopharmacology. 112
In solid tumors, the vasculature is highly abnormal in structure and function, resulting in the formation of an immunosuppressive tumor microenvironment by limiting immune cells infiltration into tumors. Vascular normalization is receiving much atten
Autor:
Yawen Xia, Hang Shi, Cheng Qian, Hongkuan Han, Keqin Lu, Ruizhi Tao, Renjun Gu, Yang Zhao, Zhonghong Wei, Yin Lu
Publikováno v:
Frontiers in Immunology. 13
BackgroundThe gut–liver axis plays a crucial role in various liver diseases. Therefore, targeting this crosstalk may provide a new treatment strategy for liver diseases. However, the exact mechanism underlying this crosstalk and its impact on drug-
Publikováno v:
Frontiers in Immunology. 13
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
The human body and its microbiome constitute a highly delicate system. The gut microbiome participates in the absorption of the host’s nutrients and metabolism, maintains the microcirculation, and modulates the immune response. Increasing evidence
Autor:
Yin Lu, Xin Li, Xiuli Bi, Xiaoqi Niu, Xiaolong Li, Zhe Yang, Yunsu Han, Alan K Chang, Xianran He
Publikováno v:
International immunopharmacology. 101
Neuro-inflammation is an immune response of the central nervous system (CNS) to pathogens, and it is associated with a variety of neurodegenerative diseases. Microglial cells are the main category of macrophages in the CNS parenchyma, and they repres
Autor:
Yan He, Wei Zhang, Paween Mahinthichaichan, Liyun Shi, Long He, Dakang Xu, Ningtong Zhuang, Yin Lu, Xiaoyi Liu, Yanhua Kang, Hang Zhang, Qinan Wu
Publikováno v:
Cellular and Molecular Immunology
Comprehensive immune responses are essential for eliminating pathogens but must be tightly controlled to avoid sustained immune activation and potential tissue damage. The engagement of TLR4, a canonical pattern recognition receptor, has been propose
Autor:
Qinan Wu, Cheng Cheng, Weihong Ge, Wei Zhang, Bo Zhu, Yin Lu, Liyun Shi, Wenbin Shang, Shiqin Zhuo, Long He
Publikováno v:
International Immunopharmacology. 72:195-203
The bacterial pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA) is a potentially fatal disease, featured with extensive infection, inflammation, and airway dysfunction. With the increasing emerging of drug-resistant strains, new
Publikováno v:
Cell Death and Disease, Vol 10, Iss 7, Pp 1-17 (2019)
Cell Death & Disease
Cell Death & Disease
The transient receptor potential ion-channel superfamily consists of nonselective cation channels located mostly on the plasma membranes of numerous animal cell types, which are closely related to sensory information transmission (e.g., vision, pain,