Zobrazeno 21 - 30
of 97
pro vyhledávání: '"Winfred C Wang"'
Autor:
Carolyn Hoppe, Michelle Green, Ganesh Balaratnam, Josh Lehrer, Margaret Tonda, Sandra V. Dixon, Erica Fong, Carla Washington, Clark Brown, Winfred C. Wang, Adlette Inati, Athiwat Hutchaleelaha
Publikováno v:
Blood. 130:980-980
Background: Sickle cell disease (SCD) is caused by polymerization of hemoglobin S (HbS), resulting in hemolysis and vaso-occlusion. Currently, no therapy achieving direct pancellular inhibition of HbS polymerization is available for adults or childre
Autor:
Winfred C. Wang, Margaret Tonda, Adlette Inati, Clark Brown, Connie M. Piccone, Carla Washington, Robert Liem, Sandy Dixon, Victor R. Gordeuk, Yifah Yaron, Gerald M. Woods, Erica Fong, Carolyn Hoppe, Ganesh Balaratnam, Josh Lehrer
Publikováno v:
Blood. 130:689-689
Background: Sickle cell disease (SCD) is a genetic disorder in which deoxygenation produces polymerization of mutated hemoglobin S (HbS) and triggers the downstream effects of red blood cell deformation (sickling), hemolysis, vaso-occlusion and infla
Autor:
Jeremie H. Estepp, Jane S. Hankins, Winfred C. Wang, Kathleen J. Helton, Jane E. Schreiber, Chen Li, Guolian Kang
Publikováno v:
ResearcherID
Background: Sickle cell anemia is associated with progressive compromise of neurocognitive function exacerbated by stroke or silent cerebral infarction. Despite decades of experience with chronic transfusion, hematopoietic stem cell transplantation,
Autor:
William Schaffner, Natasha B. Halasa, Sadhna M. Shankar, Allen S. Craig, Patrick G. Arbogast, Marie R. Griffin, Winfred C. Wang, Ed Mitchel, Thomas R. Talbot
Publikováno v:
Clinical Infectious Diseases. 44:1428-1433
Background. We sought to determine the incidence of invasive pneumococcal disease (IPD) among individuals with sickle cell disease (SCD) before and after the introduction of the pneumococcal conjugate vaccine (PCV).Methods. Individuals with SCD who w
Autor:
Robert J. Adams, Winfred C. Wang, Suzanne Granger, Miguel R. Abboud, Charles H. Pegelow, Jonathan S. Lewin, Joel K. Curé, Donald Brambilla, Lewis L. Hsu, Robert A. Zimmermann, Dianne Gallagher, Gerald M. Woods, Brian Berman
Publikováno v:
Blood. 103:2822-2826
The stroke prevention study in sickle cell disease (STOP) demonstrated a 90% reduction in stroke risk with transfusion among patients with time-averaged mean cerebral blood velocity (TAMV) of 200 cm/s or more as measured by transcranial Doppler (TCD)
Autor:
Carlos Rodriguez-Galindo, Kenneth Kaushansky, Paula Naidu, Martha Rieman, Jane S. Hankins, Winfred C. Wang
Publikováno v:
Journal of Pediatric Hematology/Oncology. 26:142-145
Patients with essential thrombocythemia (ET) usually have normal thrombopoietin (TPO) concentrations because of negative feedback from thrombocytosis. TPO mutations in familial ET cases result in increased translation efficiency with excessive TPO st
Autor:
Usman Yusuf, Xiaohua Chen, Ely Benaim, Wing Leung, John M. Cunningham, Winfred C. Wang, Gregory A. Hale, Rupert Handgretinger, Paul Woodard, Jim Houston, Kimberly A. Kasow, Edwin M. Horwitz
Publikováno v:
Bone Marrow Transplantation. 33:411-418
Peritransplant toxicity and a delay in effective immune reconstitution have limited the utility of alternate donor transplantation for children with refractory severe aplastic anemia. We have assessed the effectiveness of infusing large numbers of hi
Autor:
Dianne Gallagher, Eric A. Macklin, Ludovico Guarini, Thomas R. Kinney, Charles H. Pegelow, Michael R. DeBaun, Robert A. Zimmerman, Winfred C. Wang, Franklin G. Moser, Donald P. Younkin, Jacqueline A. Bello, Elliott Vichinsky, Scott T. Miller
Publikováno v:
Blood. 99:3014-3018
Children with sickle cell anemia (HbSS) are at high risk for neurologically overt cerebral infarcts associated with stroke and neurologically silent cerebral infarcts correlated with neuropsychometric deficit. We used complete magnetic resonance imag
Autor:
Patrick Kelly, Carlos Rodriguez-Galindo, Gerald G. Presbury, Michael Jeng, Martha Rieman, Winfred C. Wang
Publikováno v:
American Journal of Hematology. 69:179-184
Langerhans cell histiocytosis (LCH) is a disorder characterized by proliferation of activated Langerhans cells. Immune dysregulation is believed to be part of the pathogenesis. Although current therapies are very effective at inducing remission, mult
Autor:
Charles Daeschner, Russell E. Ware, Barry Eggleston, Lori Styles, Kim Smith-Whitley, Thomas R. Kinney, Rupa Redding-Lallinger, Winfred C. Wang, Ronald W. Helms, Beatrice E. Gee, Kwaku Ohene-Frempong
Publikováno v:
Blood. 99:10-14
In the phase I/II pediatric hydroxyurea safety trial (HUG-KIDS), school-aged children with sickle cell anemia receiving hydroxyurea at the maximally tolerated dose (MTD) had variable increases in the percentage of fetal hemoglobin (%HbF). To identify