Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Toshiyuki Takehara"'
Autor:
Maki Itokazu, Toshiyuki Takehara, Tatsufumi Mori, Takeshi Teramura, Yuta Onodera, Kanji Fukuda
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204860 (2018)
PLoS ONE
PLoS ONE
Tissue renewal and muscle regeneration largely rely on the proliferation and differentiation of muscle stem cells called muscular satellite cells (MuSCs). MuSCs are normally quiescent, but they are activated in response to various stimuli, such as in
Publikováno v:
FEBS Open Bio
FEBS Open Bio, Vol 5, Iss 1, Pp 476-484 (2015)
FEBS Open Bio, Vol 5, Iss 1, Pp 476-484 (2015)
Highlights • Hyaluronic acid (HA) has a pharmacological role for reduction of cellular superoxide. • In HA-treated chondrocytes, expression of Nrf2 and its downstream genes was upregulated. • Inhibition of Akt or suppression of HA receptors pre
Autor:
Yuta Kida, Yuta Onodera, John P. Frampton, Yoshihiko Hosoi, Takeshi Teramura, Naoto Fukunaga, Hiroki Izumi, Hironobu Sugimoto, Kanji Fukuda, Makiko Kawakami, Toshiyuki Takehara, Miho Nakano
Publikováno v:
Stem Cells and Development. 22:928-938
In mammalian ovaries, many immature follicles remain after the dominant follicles undergo ovulation. Here we report the successful production of rabbit embryonic stem cells (ESCs) from oocytes produced by in vitro culture of immature follicles and su
Autor:
Kanji Fukuda, John P. Frampton, Yoshihisa Miki, Toshiyuki Takehara, Yoshihiko Hosoi, Koichi Nakagawa, Chiaki Hamanishi, Syunsuke Ito, Toshiki Matsuoka, Takeshi Teramura, Yuta Onodera
Publikováno v:
Cell Transplantation, Vol 22 (2013)
Embryonic stem cells (ESCs) have the potential to be used as an unlimited cell source for cell transplantation therapy, as well as for studying mechanisms of disease and early mammalian development. However, applications involving ESCs have been limi
Publikováno v:
FEBS Open Bio
FEBS Open Bio, Vol 5, Iss 1, Pp 492-501 (2015)
FEBS Open Bio, Vol 5, Iss 1, Pp 492-501 (2015)
Highlights • Oxidative stress in the arthritis joint is involved in generating mediators for inflammation. • Oxidative stress-induced expression of Cox-2 was mediated by MAPKs and NF-κB. • ROS-induced MAPKs and NF-κB were attenuated by inhibi
Autor:
Kanji Fukuda, Takeshi Teramura, Chiaki Hamanishi, Koichi Nakagawa, Yuta Onodera, Masao Akagi, Toshiyuki Takehara
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 61(10)
Excessive mechanical stress on the cartilage causes the degradation of the matrix, leading to the osteoarthritis (OA). Matrix metalloproteinases 13 (MMP13) is a major catalytic enzyme in OA and p38 plays an important role in its induction. However, p
Autor:
Toshiyuki Takehara, Takeshi Teramura, Yoshihiko Hosoi, Satoshi Kishigami, Kazuhiro Saeki, Kazuya Matsumoto, Yuta Onodera, Kanji Fukuda
Publikováno v:
Stem cells and development. 18(10)
Neural stem cells (NSCs) are tissue-specific stem cells with self-renewal potential in brain, and are committed cells of the central nervous system. Recently, some reports have suggested the possibility of the NSCs to differentiate into non-CNS mesod