Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Thomas Lehner"'
Autor:
K. Pervin, A. Hasan, D. C. Dumonde, Yutaka Mizushima, Thomas M. Shinnick, R. Whiston, H. Direskeneli, Miles Stanford, Thomas Lehner, R van der Zee, A. Childerstone, E. Kasp
Publikováno v:
Stress Proteins in Medicine ISBN: 9781003067474
Behcet's disease (BD) was first described by Hippocrates in ancient Greece, and the disease is named after Hulusi Behcet, a Turkish dermatologist. It is a multisystem disorder with oral and genital ulcers, uveitis, and cutaneous, arthritic, and neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55c551deaac279f8463e7319eb8076fa
https://doi.org/10.1201/9781003067474-10
https://doi.org/10.1201/9781003067474-10
Autor:
Meera E. Modi, Stephen Sanders, Guoping Feng, Paul Avillach, Carrie E. Bearden, Anne Pariser, Thomas Lehner, Andres Moreno-De-Luca, Audrey Thurm, David H. Ledbetter, Raquel E. Gur, Elise Douard, Jonathan Sebat, Joseph Hostyk, Ricardo E. Dolmetsch, David B. Goldstein, Daniel H. Geschwind, Christa Lese Martin, David C. Glahn, Sébastien Jacquemont, Armin Raznahan, Mustafa Sahin, Rodney C. Samaco, Alan Anticevic, Jennifer G. Mulle, Sergiu P. Paşca
Publikováno v:
Nat Med
other univ website
Nature medicine, vol 25, iss 10
other univ website
Nature medicine, vol 25, iss 10
De novo and inherited rare genetic disorders (RGDs) are a major cause of human morbidity, frequently involving neuropsychiatric symptoms. Recent advances in genomic technologies and data sharing have revolutionized the identification and diagnosis of
Autor:
Robin J. Shattock, Mahavir Singh, Kaboutar Babaahmady, Zhiming Huo, Thomas Lehner, Yufei Wang, Durdana Rahman, Raphaela Giemza, David J. M. Lewis
Publikováno v:
Journal of Virology. 88:11648-11657
The international effort to prevent HIV-1 infection by vaccination has failed to develop an effective vaccine. The aim of this vaccine trial in women was to administer by the vaginal mucosal route a vaccine consisting of HIV-1 gp140 linked to the cha
Autor:
Nelson L. Michael, Xuesong Yu, Mukesh Mistry, Merlin L. Robb, Gary Britton, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Alicia Sato, Robert J. O'Connell, Stuart J. D. Neil, Thomas Lehner, Jaranit Kaewkungwal, Trevor Whittall, Punnee Pitisuttithum, Yufei Wang, Jerome H. Kim
Publikováno v:
Wang, Y, Whittall, T, Neil, S, Britton, G, Mistry, M, Rerks-Ngarm, S, Pitisuttithum, P, Kaewkungwal, J, Nitayaphan, S, Yu, X, Sato, A, O'Connell, R J, Michael, N L, Robb, M L, Kim, J H & Lehner, T 2017, ' A novel mechanism linking memory stem cells with innate immunity in protection against HIV-1 infection ', Scientific Reports, vol. 7, no. 1, 1057 . https://doi.org/10.1038/s41598-017-01188-3
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
HIV infection affects 37 million people and about 1.7 million are infected annually. Among the phase III clinical trials only the RV144 vaccine trial elicited significant protection against HIV-1 acquisition, but the efficacy and immune memory were i
Publikováno v:
Journal of Biological Chemistry. 287:17152-17160
The efficacy of a vaccine is generally dependent on an adjuvant, which enhances the immune functions and alum has been widely used in human immunization. Alum activates the intracellular stress sensors inflammasomes, but whether these are responsible
Publikováno v:
Immunology. 135:207-215
Summary B cells express two critical deaminases in the development of adaptive and innate immunity. Activation-induced cytidine deaminase (AID) functions in class switch recombination, somatic hypermutation and may result in affinity maturation of an
Publikováno v:
Advances in Dental Research. 23:19-22
HIV-1 is predominantly transmitted through mucosal tissues, targeting CD4+CCR5+ T cells, 50% of which are destroyed within 2 weeks of infection. Conventional vaccination strategies have so far failed to prevent HIV-1 infection. Neither antibodies nor
Autor:
Mahavir Singh, Lesley A. Bergmeier, Jørgen Schøller, Durdana Rahman, J. Pido-Lopez, Thomas Lehner, Trevor Whittall, Katja Brunstedt, Yufei Wang
Publikováno v:
Journal of Immunological Methods. 360:1-9
The objective of this study was to produce and evaluate the immunogenic potential of a recombinant HLA-class I antigen linked to dextran. The HLA-A*0201 heavy chain and β2 microglobulin were cloned by PCR amplification of overlapping oligonucleotide
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 77:39-39
Publikováno v:
European Journal of Immunology. 40:1628-1638
Evidence is presented that thermal or oxidizing stress-activated DC interact with CD4(+) T cells to induce and maintain a TCR-independent homeostatic memory circuit. Stress-activated DC expressed endogenous intra-cellular and cell surface HSP70. The