Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Robert Rottapel"'
Autor:
Ioannis D. Dimitriou, David Meiri, Yulia Jitkova, Alisha R. Elford, Marianne Koritzinsky, Aaron D. Schimmer, Pamela S. Ohashi, Nahum Sonenberg, Robert Rottapel
Publikováno v:
The Journal of Immunology. 208:2702-2712
CD8+ T cell proliferation and differentiation into effector and memory states are high-energy processes associated with changes in cellular metabolism. CD28-mediated costimulation of T cells activates the PI3K/AKT/mammalian target of rapamycin signal
Autor:
Yosuke Asano, Yoshinori Matsumoto, Fang He, Takayuki Katsuyama, Eri Katsuyama, Shigetomo Tsuji, Hiroshi Kamioka, Jose La Rose, Robert Rottapel, Jun Wada
Publikováno v:
Clinical and Experimental Rheumatology.
Autor:
Uriel Trahtemberg, Andrew J. Baker, Marvin J. Fritzler, Claudia C. dos Santos, Arthur S. Slutsky, Robert Rottapel
Publikováno v:
Annals of the Rheumatic Diseases
BackgroundReports of severe COVID-19 being associated with thrombosis, antiphospholipid antibodies (APLA), and antiphospholipid syndrome have yielded disparate conclusions. Studies comparing patients with COVID-19 with contemporaneous controls of sim
Autor:
Tatiana Nevskaya, Shahin Jamal, Ines Colmegna, Aurore Fifi-Mah, Nancy Maltez, Karam Al Jumaily, Annaliese Tisseverasinghe, Carrie Ye, Sabrina Hoa, Megan E. Himmel, Janet Roberts, Marie Hudson, Daniel Ennis, Janet E. Pope, Robert Rottapel, Christina Ly, Linda Laaouad, Alexandra Saltman
Publikováno v:
Cancer Immunology, Immunotherapy. 70:2197-2207
Limited data are available on the safety and efficacy of immune checkpoint inhibitors (ICI) in patients with preexisting autoimmune diseases (PAD). Retrospective study of patients with PAD referred for rheumatologic evaluation prior to starting or du
Publikováno v:
Frontiers in Immunology. 14:1120710
Ubiquitin-mediated proteasomal degradation is a post-transcriptional protein modification that is comprised of various components including the 76-amino acid protein ubiquitin (Ub), Ub-activating enzyme (E1), Ub-conjugating enzyme (E2), ubiquitin lig
Autor:
Robert Rottapel, Yoshinori Matsumoto
Publikováno v:
Immunological Medicine, Vol 43, Iss 2, Pp 61-64 (2020)
The adaptor protein 3BP2 (SH3-domain binding protein 2), which is encoded by the SH3BP2 locus, nucleates a signaling complex comprising ABL, SRC, VAV, and SYK, and facilitates an open active configuration of these proteins, leading to their kinase ac
Autor:
Sabrina Hoa, Alexandra Saltman, Shahin Jamal, Carrie Ye, Janet E. Pope, Annaliese Tisseverasinghe, Megan E. Himmel, Aurore Fifi-Mah, Janet Roberts, Robert Rottapel, Marie Hudson, Daniel Ennis, Nancy Maltez
Publikováno v:
Autoimmunity reviews. 19(8)
Objective Although immune checkpoint inhibitors (ICI) have revolutionized cancer therapy, their use is associated with immune toxicities referred to as immune-related adverse events (irAE). Here we describe the clinical presentation and management of
Autor:
Brian T. Gaudette, Junhyong Kim, Richa Kapoor, Rui Wu, Reiner Siebert, Julian Seufert, Louis M. Staudt, Philippe Szankasi, Kaiyu Ma, Xiao Zhang, Özlem Önder, Kevin P. Conlon, Cristina López, Anagh A. Sahasrabuddhe, Fuzon Chung, Xiaofei Chen, David Allman, Venkatesha Basrur, Joel R. Wilmore, Michael P. Cancro, Nathanael G. Bailey, Vinodh Pillai, Kojo S.J. Elenitoba-Johnson, Rishi Raj Chhipa, Robert Rottapel, Joon-Young Ahn, Megan S. Lim, Marilyn M. Li, Matthias Schlesner, Cory M. Hogaboam, Michele Pagano
Publikováno v:
Blood. 138:711-711
Introduction: Diffuse large B cell lymphoma (DLBCL) is the most common form of malignant lymphoma and may arise de novo, or through transformation from a pre-existing low-grade B cell lymphoma such as follicular lymphoma (FL). However, the post-trans
Publikováno v:
Oncotarget
// Oliver A. Kent 1 , Maria-Jose Sandi 1 , Helen E. Burston 1 , Kevin R. Brown 2 , Robert Rottapel 1, 3, 4, 5, 6 1 Princess Margaret Cancer Centre, University Health Network, Toronto Medical Discovery Tower, University of Toronto, Toronto, Canada 2 D
Autor:
Hisham Ibrahim, Myron I. Cybulsky, María José Sandí, Björn Petri, Jacob Rullo, Paul Kubes, Michael Glogauer, Jose La Rose, Noah Fine, Ioannis D. Dimitriou, Jack Haitsma, Robert Rottapel
Publikováno v:
The Journal of Cell Biology
Journal of Cell Biology, 215(1), 107-119. Rockefeller University Press
Fine, N, Dimitriou, I D, Rullo, J, Sandi, M J, Petri, B, Haitsma, J, Ibrahim, H, La Rose, J, Glogauer, M, Kubes, P, Cybulsky, M & Rottapel, R 2016, ' GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation ', Journal of Cell Biology, vol. 215, no. 1, pp. 107-119 . https://doi.org/10.1083/jcb.201603109
Journal of Cell Biology, 215(1), 107-119. Rockefeller University Press
Fine, N, Dimitriou, I D, Rullo, J, Sandi, M J, Petri, B, Haitsma, J, Ibrahim, H, La Rose, J, Glogauer, M, Kubes, P, Cybulsky, M & Rottapel, R 2016, ' GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation ', Journal of Cell Biology, vol. 215, no. 1, pp. 107-119 . https://doi.org/10.1083/jcb.201603109
In their work, Fine et al. demonstrate that GEF-H1 is required for the spreading and crawling of neutrophils in response to intravascular blood flow. They uncover a novel mechanism that couples shear stress with Rho-dependent migratory behavior of ne