Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Philip Hopkins"'
Autor:
Anna L. McNaughton, Robert S. Paton, Matthew Edmans, Jonathan Youngs, Judith Wellens, Prabhjeet Phalora, Alex Fyfe, Sandra Belij-Rammerstorfer, Jai S. Bolton, Jonathan Ball, George W. Carnell, Wanwisa Dejnirattisai, Christina Dold, David W. Eyre, Philip Hopkins, Alison Howarth, Kreepa Kooblall, Hannah Klim, Susannah Leaver, Lian Ni Lee, César López-Camacho, Sheila F. Lumley, Derek C. Macallan, Alexander J. Mentzer, Nicholas M. Provine, Jeremy Ratcliff, Jose Slon-Compos, Donal Skelly, Lucas Stolle, Piyada Supasa, Nigel Temperton, Chris Walker, Beibei Wang, Duncan Wyncoll, Oxford Protective T Cell Immunology for COVID-19 (OPTIC) consortium, Scottish National Blood Transfusion Service (SNBTS) consortium, Peter Simmonds, Teresa Lambe, John Kenneth Baillie, Malcolm G. Semple, Peter J.M. Openshaw, International Severe Acute Respiratory and emerging Infection Consortium Coronavirus Clinical Characterisation Consortium (ISARIC4C) investigators, Uri Obolski, Marc Turner, Miles Carroll, Juthathip Mongkolsapaya, Gavin Screaton, Stephen H. Kennedy, Lisa Jarvis, Eleanor Barnes, Susanna Dunachie, José Lourenço, Philippa C. Matthews, Tihana Bicanic, Paul Klenerman, Sunetra Gupta, Craig P. Thompson
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
The role of immune responses to previously seen endemic coronavirus epitopes in severe acute respiratory coronavirus 2 (SARS-CoV-2) infection and disease progression has not yet been determined. Here, we show that a key characteristic of fatal outcom
Externí odkaz:
https://doaj.org/article/842340fbdef543a0831407713fb7ad30
Autor:
Panagiota Zacharopoulou, David A. Duncan, Susanna Dunachie, Nicholas T.Y. Lim, Robert S. Paton, Craig Thompson, Ian D. Pavord, Derek C. Macallan, W J Hurt, Wentao Chen, Donal T. Skelly, P Goulder, Graham S. Ogg, Jian Luo, Wyncoll Dla., Nicholas M. Provine, Luzheng Xue, Chen Y-L., Philip Hopkins, Ali Amini, E Barnes, Matthew Edmans, Jonathan Ball, Jonathan Youngs, Anna L McNaughton, Paul Klenerman, Hannah Sharpe, Teresa Lambe, Vincent N. Miao, Oliver Sampson, Alex K. Shalek, Tihana Bicanic, Susannah Leaver
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009804 (2021)
et al. 2021, ' Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients ', PLoS Pathogens, vol. 17, no. 9, e1009804 . https://doi.org/10.1371/journal.ppat.1009804
PLoS Pathogens
et al. 2021, ' Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients ', PLoS Pathogens, vol. 17, no. 9, e1009804 . https://doi.org/10.1371/journal.ppat.1009804
PLoS Pathogens
Prior studies have demonstrated that immunologic dysfunction underpins severe illness in COVID-19 patients, but have lacked an in-depth analysis of the immunologic drivers of death in the most critically ill patients. We performed immunophenotyping o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d1affc75f71fbb1aaddb6a4c83a3de
https://doi.org/10.1371/journal.ppat.1009804
https://doi.org/10.1371/journal.ppat.1009804
Autor:
Anna L. McNaughton, Robert S. Paton, Matthew Edmans, Jonathan Youngs, Judith Wellens, Prabhjeet Phalora, Alex Fyfe, Sandra Belij-Rammerstorfer, Jai S. Bolton, Jonathan Ball, George W. Carnell, Wanwisa Dejnirattisai, Christina Dold, David W. Eyre, Philip Hopkins, Alison Howarth, Kreepa Kooblall, Hannah Klim, Susannah Leaver, Lian Ni Lee, César López-Camacho, Sheila F. Lumley, Derek C. Macallan, Alexander J. Mentzer, Nicholas M. Provine, Jeremy Ratcliff, Jose Slon-Compos, Donal Skelly, Lucas Stolle, Piyada Supasa, Nigel Temperton, Chris Walker, Beibei Wang, Duncan Wyncoll, Peter Simmonds, Teresa Lambe, John Kenneth Baillie, Malcolm G. Semple, Peter J.M. Openshaw, Uri Obolski, Marc Turner, Miles Carroll, Juthathip Mongkolsapaya, Gavin Screaton, Stephen H. Kennedy, Lisa Jarvis, Eleanor Barnes, Susanna Dunachie, José Lourenço, Philippa C. Matthews, Tihana Bicanic, Paul Klenerman, Sunetra Gupta, Craig P. Thompson
Publikováno v:
Paton, R S, Edmans, M, Youngs, J C, Wellens, J, Phalora, P, Fyfe, A, Belij-Rammerstorfer, S, Bolton, J S, Ball, J, Carnell, G W, Dejnirattisai, W, Dold, C, Hopkins, P, Howarth, A, Kooblall, K, Klim, H, Leaver, S, Lee, L N, López-Camacho, C, Lumley, S F, Macallan, D C, Mentzer, A J, Provine, N M, Ratcliff, J, Slon-Campos, J L, Skelly, D T, Stolle, L B, Supasa, P, Temperton, N, Walker, C, Wang, B, Wyncoll, D, Lambe, T, Ballie, J K, Semple, M G, Openshaw, P J, Obolski, U, Turner, M, Carroll, M, Mongkolsapaya, J, Screaton, G, Kennedy, S H, Jarvis, L M, Barnes, E, Dunachie, S, Lourenço, J, Matthews, P C, Bicanic, T, Klenerman, P, Gupta, S, Thompson, C P & McNaughton, A 2022, ' Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses ', JCI Insight, vol. 7, no. 13, e156372 . https://doi.org/10.1172/jci.insight.156372
The role of immune responses to previously seen endemic coronavirus epitopes in severe acute respiratory coronavirus 2 (SARS-CoV-2) infection and disease progression has not yet been determined. Here, we show that a key characteristic of fatal outcom
Autor:
Derek C. Macallan, David W Eyre, J Slon-Campos, Susannah Leaver, Jai S Bolton, Lian Lee, Jeremy Ratcliff, Kreepa Kooblall, Christopher J. Walker, Marc Turner, Beibei Wang, Judith Wellens, José Lourenço, Christina Dold, Sheila F Lumley, Paul M. Matthews, Hannah Klim, J K Baillie, George Carnell, Juthathip Mongkolspaya, Philip Hopkins, Piyada Supasa, Alexander J. Mentzer, Duncan Wyncoll, Lucas Stolle, Wanwisa Dejnirattisai, Susanna Dunachie, Miles W. Carroll, Nigel Temperton, E Barnes, Robert S. Paton, Prabhjeet Phalora, Sandra Belij-Rammerstorfer, Sunetra Gupta, Stephen Kennedy, Malcom G Semple, Teresa Lambe, Provine N, Tihana Bicanic, Matthew Edmans, Alex Fyfe, Gavin R. Screaton, Donal T. Skelly, Anna L McNaughton, Paul Klenerman, Craig Thompson, Cesar Lopez-Camacho, Peter J. M. Openshaw, Lisa Jarvis, Uri Obolski, A Howarth, Jonathan Youngs, Investigators I, Peter Simmonds, Jonathan Ball
SummaryIt is unclear whether prior endemic coronavirus infections affect COVID-19 severity. Here, we show that in cases of fatal COVID-19, antibody responses to the SARS-COV-2 spike are directed against epitopes shared with endemic beta-coronaviruses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1579a3ab0f83669ff17997dd56f633e9
https://doi.org/10.1101/2021.05.04.21256571
https://doi.org/10.1101/2021.05.04.21256571
Autor:
Philip Hopkins, L. Jonathan Cohen
Publikováno v:
Critical Care. 6:99
Severe sepsis continues to lead to critical illness. Few therapeutic options exist other than antibiotic therapy and general supportive care. Large numbers of patients continue to die as a consequence of overactivation of the host inflammatory respon