Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kelly M. Ramsbottom"'
Autor:
Tanja Fauti, Lisa Wellinger, Joseph A. Trapani, Axel Paehler, Daniela Geiss, Kelly M Ramsbottom, Laura Jarassier, Phillip Thienger, Leonie A. Cluse, Conor J. Kearney, Thomas Friess, Stephin J. Vervoort, Jane Oliaro, Daniel Rohle, Ricky W. Johnstone, Marina Bacac, Simon J. Hogg, Astrid Ruefli-Brasse, Dane M. Newman, Daniel Marbach, Jake Shortt, Jessica Michie
Publikováno v:
Cancer Immunology Research. 10:87-107
Targeting chromatin binding proteins and modifying enzymes can concomitantly affect tumor cell proliferation and survival, as well as enhance antitumor immunity and augment cancer immunotherapies. By screening a small-molecule library of epigenetics-
Autor:
Emily J. Lelliott, Kelly M. Ramsbottom, Mark R. Dowling, Carolyn Shembrey, Tahereh Noori, Conor J. Kearney, Jessica Michie, Ian A. Parish, Margaret A. Jordan, Alan G. Baxter, Neil D. Young, Amelia J. Brennan, Jane Oliaro
Publikováno v:
Frontiers in Immunology. 13
Cytotoxic lymphocytes are essential for anti-tumor immunity, and for effective responses to cancer immunotherapy. Natural killer cell granule protein 7 (NKG7) is expressed at high levels in cytotoxic lymphocytes infiltrating tumors from patients trea
SUGAR-seq enables simultaneous detection of glycans, epitopes, and the transcriptome in single cells
Autor:
Magnus Zethoven, Lizzy Pijpers, Conor J. Kearney, Ben P. Martin, Luciano G. Martelotto, Jane Oliaro, Nichollas E. Scott, Stephin J. Vervoort, Timothy Semple, Ian A. Parish, Joseph A. Trapani, Emily J. Lelliott, Ricky W. Johnstone, Kelly M Ramsbottom, Izabela Todorovski
Publikováno v:
Science Advances
A new technology, SUGAR-seq, enables simultaneous detection of surface glycans, epitopes, transcripts, and TCR repertoire.
Multimodal single-cell RNA sequencing enables the precise mapping of transcriptional and phenotypic features of cellular d
Multimodal single-cell RNA sequencing enables the precise mapping of transcriptional and phenotypic features of cellular d
Autor:
Grant A. McArthur, Riyaben P. Patel, Carleen Cullinane, Claire Martin, Anthony T. Papenfuss, Amanda J Oliver, Kelly M Ramsbottom, Emily J. Lelliott, Nicole M. Haynes, Stefano Mangiola, Peter Lau, Lydia Lim, Jane Oliaro, Laura Kirby, Karen E. Sheppard, Magnus Zethoven, Luciano G. Martelotto, Alison Slater
Publikováno v:
Cancer immunology research. 9(2)
Combined inhibition of BRAF, MEK, and CDK4/6 is currently under evaluation in clinical trials for patients with melanoma harboring a BRAFV600 mutation. While this triple therapy has potent tumor-intrinsic effects, the impact of this combination on an
Autor:
Kelly M Ramsbottom, Ricky W. Johnstone, Capucine Picard, Conor J. Kearney, Andrew J. Freeman, Jessica Michie, Cindy S. Ma, Stuart G. Tangye, Stephin J. Vervoort, Jean-Laurent Casanova, Katrina L. Randall, Jane Peake, Jane Oliaro
Publikováno v:
The Journal of Immunology. 199:2118-2127
Mutations in the dedicator of cytokinesis 8 (DOCK8) gene cause an autosomal recessive form of hyper-IgE syndrome, characterized by chronic immunodeficiency with persistent microbial infection and increased incidence of malignancy. These manifestation
Autor:
Conor J. Kearney, John Silke, Kelly M Ramsbottom, Andrew J. Freeman, Jane Oliaro, Najoua Lalaoui
Publikováno v:
Cell Death & Differentiation. 24:1705-1716
Smac-mimetics are emerging as promising anti-cancer agents and are being evaluated in clinical trials for a variety of malignancies. Smac-mimetics can induce TNF production from a subset of tumor cells and simultaneously sensitize them to TNF-induced
Autor:
Kelly M Ramsbottom, Ilia Voskoboinik, Najoua Lalaoui, Conor J. Kearney, Paul A. Beavis, Jane Oliaro, Ricky W. Johnstone, Andrew J. Freeman, Robert G. Ramsay, Emily J. Lelliott, Jessica Michie, John Silke, Vignesh Narasimhan, Phillip K. Darcy, Stephin J. Vervoort
Publikováno v:
Cancer immunology research. 7(2)
Chimeric antigen receptor (CAR) T-cell therapy has proven successful in the treatment of hematological malignancies, notably acute lymphoblastic leukemia and B-cell lymphoma. However, the efficacy of CAR T cells against solid tumors is poor, likely d
Autor:
Kristin K. Brown, Ricky W. Johnstone, Ilia Voskoboinik, John Silke, Joseph A. Trapani, Stephin J. Vervoort, Conor J. Kearney, Andrew J. Freeman, Paul A. Beavis, Kelly M Ramsbottom, Vivien R. Sutton, Jessica Michie, Lizzy Pijpers, Phil Darcy, Simon J. Hogg, Deborah A. Knight, Jane Oliaro, Najoua Lalaoui
Publikováno v:
Science Immunology. 3
Immunotherapy has revolutionized outcomes for cancer patients, but the mechanisms of resistance remain poorly defined. We used a series of whole-genome clustered regularly interspaced short palindromic repeat (CRISPR)-based screens performed in vitro
Autor:
Amelia J. Brennan, Ilia Voskoboinik, Joseph A. Trapani, Jane Oliaro, Imran G House, Kelly M Ramsbottom, Magdalena Hagn, Hideo Yagita
Publikováno v:
The Journal of Immunology. 193:5744-5750
Cytotoxic lymphocytes destroy pathogen-infected and transformed cells through the cytotoxic granule exocytosis death pathway, which is dependent on the delivery of proapoptotic granzymes into the target cell cytosol by the pore-forming protein, perfo
Autor:
Jane Oliaro, Kelly M Ramsbottom, Raz Shimoni, Sarah M. Russell, Mark J. Smyth, Christopher J. Chan, Mairi McGrath, Edwin D. Hawkins
Publikováno v:
The Journal of Immunology. 192:553-557
DNAX accessory molecule 1 (DNAM-1) is expressed on all CD8+ T cells and promotes their activation and effector function. DNAM-1 interacts with LFA-1, a critical molecule for immunological synapse formation between T cells and APCs, and for cytotoxic