Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Karel Hählen"'
Autor:
Gertjan J.L. Kaspers, Bianca F. Goemans, Nancy Boeckx, Corine J. Hess, S Corthals, Dirk Reinhardt, Karel Hählen, J.W. van Oostveen, Jacqueline Cloos, Gerrit-Jan Schuurhuis, D de Lange, Quinten Waisfisz, U. Creutzig, Ch. M. Zwaan
Publikováno v:
Cloos, J, Goemans, B F, Hess, C J, van Oostveen, J W, Waisfisz, Q, Corthals, S, de lange, D, Boeckx, N, Hahlen, K, Reinhardt, D, Creutzig, U, Schuurhuis, G J, Zwaan, C M & Kaspers, G J L 2006, ' Stability and prognostic influence of FLT3 mutations in paired initial and relapsed AML samples ', Leukemia, vol. 20, no. 7, pp. 1217-1220 . https://doi.org/10.1038/sj.leu.2404246
Leukemia, 20(7), 1217-1220. Nature Publishing Group
Leukemia, 20, 1217-1220. Nature Publishing Group
Leukemia, 20(7), 1217-1220. Nature Publishing Group
Leukemia, 20, 1217-1220. Nature Publishing Group
In acute myeloid leukemia (AML), activating mutations in the fms-like tyrosine kinase 3 (FLT3) gene predict poor prognosis. We determined FLT3 internal tandem duplications (FLT3/ITD) and D835 point mutations in paired initial and relapse samples from
Autor:
A H Loonen, Christian M. Zwaan, Bianca F. Goemans, Dirk Reinhardt, Karel Hählen, Gertjan J.L. Kaspers, Amy Harlow, Brenda Gibson, Ursula Creutzig, Michael Heinrich
Publikováno v:
Blood, 106(10), 3532-3537. American Society of Hematology
Goemans, B F, Zwaan, C M, Harlow, A, Loonen, A H, Gibson, B E S, Hählen, K, Reinhardt, D, Creutzig, U, Heinrich, M C & Kaspers, G J L 2005, ' In vitro profiling of the sensitivity of pediatric leukemia cells to tipifarnib : Identification of T-cell ALL and FAB M5 AML as the most sensitive subsets ', Blood, vol. 106, no. 10, pp. 3532-3537 . https://doi.org/10.1182/blood-2005-04-1640
Goemans, B F, Zwaan, C M, Harlow, A, Loonen, A H, Gibson, B E S, Hählen, K, Reinhardt, D, Creutzig, U, Heinrich, M C & Kaspers, G J L 2005, ' In vitro profiling of the sensitivity of pediatric leukemia cells to tipifarnib : Identification of T-cell ALL and FAB M5 AML as the most sensitive subsets ', Blood, vol. 106, no. 10, pp. 3532-3537 . https://doi.org/10.1182/blood-2005-04-1640
Although the prognosis of pediatric leukemias has improved considerably, many patients still have relapses. Tipifarnib, a farnesyl transferase inhibitor (FTI), was developed to target malignancies with activated RAS, including leukemia. We tested 52
Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia
Autor:
Michael Heinrich, Ch. M. Zwaan, A H Loonen, Amy Harlow, Soheil Meshinchi, Gertjan J.L. Kaspers, Dirk Reinhardt, Karel Hählen, U Creutzig, M. Miller, Bianca F. Goemans, Martin Zimmermann
Publikováno v:
Leukemia, 19(9), 1536-1542. Nature Publishing Group
Goemans, B F, Zwaan, C M, Miller, M, Zimmermann, M, Harlow, A, Meshinchi, S, Loonen, A H, Hahlen, K, Reinhardt, D, Creutzig, U, Kaspers, G J L & Heinrich, M C 2005, ' Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia ', Leukemia, vol. 19, no. 9, pp. 1536-1542 . https://doi.org/10.1038/sj.leu.2403870
Goemans, B F, Zwaan, C M, Miller, M, Zimmermann, M, Harlow, A, Meshinchi, S, Loonen, A H, Hahlen, K, Reinhardt, D, Creutzig, U, Kaspers, G J L & Heinrich, M C 2005, ' Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia ', Leukemia, vol. 19, no. 9, pp. 1536-1542 . https://doi.org/10.1038/sj.leu.2403870
Activating mutations in RAS and receptor tyrosine kinases such as KIT and FLT3 are hypothesized to cooperate with chimeric transcription factors in the pathogenesis of acute myeloid leukemia (AML). To test this hypothesis, we genotyped 150 pediatric
Autor:
Martin Zimmermann, Jerald P. Radich, Leonhard Munske, Soheil Meshinchi, Dirk Reinhardt, Karel Hählen, Frank Griesinger, Rob Pieters, Jochen Harbott, Christian M. Zwaan, D. R. Huismans, Gertjan J.L. Kaspers, Martina Podleschny, Ursula Creutzig, Anjo J.P. Veerman
Publikováno v:
Blood, 102(7), 2387-2394. American Society of Hematology
Zwaan, C M, Meshinchi, S, Radich, J P, Veerman, A J P, Huismans, D R, Munske, L, Podleschny, M, Hählen, K, Pieters, R, Zimmermann, M, Reinhardt, D, Harbott, J, Creutzig, U, Kaspers, G J L & Griesinger, F 2003, ' FLT3 internal tandem duplication in 234 children with acute myeloid leukemia : Prognostic significance and relation to cellular drug resistance ', Blood, vol. 102, no. 7, pp. 2387-2394 . https://doi.org/10.1182/blood-2002-12-3627
Blood, 102, 2387-2394. American Society of Hematology
Zwaan, C M, Meshinchi, S, Radich, J P, Veerman, A J P, Huismans, D R, Munske, L, Podleschny, M, Hählen, K, Pieters, R, Zimmermann, M, Reinhardt, D, Harbott, J, Creutzig, U, Kaspers, G J L & Griesinger, F 2003, ' FLT3 internal tandem duplication in 234 children with acute myeloid leukemia : Prognostic significance and relation to cellular drug resistance ', Blood, vol. 102, no. 7, pp. 2387-2394 . https://doi.org/10.1182/blood-2002-12-3627
Blood, 102, 2387-2394. American Society of Hematology
FLT3 is a receptor tyrosine kinase involved in the proliferation and differentiation of hematopoietic stem cells. FLT3 internal tandem duplications (FLT3/ITDs) are reported in acute myeloid leukemia (AML) and predict poor clinical outcome. We found F
Cellular drug resistance in childhood acute myeloid leukemia is related to chromosomal abnormalities
Autor:
R. Släter, Anjo J.P. Veerman, Martin Zimmermann, Rob Pieters, Karel Hählen, D. R. Huismans, Jochen Harbott, Gertjan J.L. Kaspers, Christian M. Zwaan, U. Creutzig
Publikováno v:
Blood, 100, 3352-3360. American Society of Hematology
Blood, 100(9), 3352-3360. American Society of Hematology
Zwaan, C M, Kaspers, G J L, Pieters, R, Hählen, K, Huismans, D R, Zimmermann, M, Harbott, J, Slater, R M, Creutzig, U & Veerman, A J P 2002, ' Cellular drug resistance in childhood acute myeloid leukemia is related to chromosomal abnormalities ', Blood, vol. 100, no. 9, pp. 3352-3360 . https://doi.org/10.1182/blood.V100.9.3352
Blood, 100(9), 3352-3360. American Society of Hematology
Zwaan, C M, Kaspers, G J L, Pieters, R, Hählen, K, Huismans, D R, Zimmermann, M, Harbott, J, Slater, R M, Creutzig, U & Veerman, A J P 2002, ' Cellular drug resistance in childhood acute myeloid leukemia is related to chromosomal abnormalities ', Blood, vol. 100, no. 9, pp. 3352-3360 . https://doi.org/10.1182/blood.V100.9.3352
Specific cytogenetic abnormalities predict prognosis in childhood acute myeloid leukemia (AML). However, it is unknown why they are predictive and whether this is related to drug resistance. We previously reported that Down syndrome (DS) AML was asso
Autor:
W.G. Kroes, Susana C. Raimondi, E. van den Berg, E van Drunen, Karel Hählen, A. van der Does-van den Berg, Daniel Olde Weghuis, Rosalyn Slater, H B Beverloo, E.M.E. Smit, Andrew J. Carroll, E. R. Van Wering
Publikováno v:
Leukemia, 15(6), 915-920. Nature Publishing Group
Our retrospective karyotype review revealed two rare recurrent translocations affecting ETV6 (TEL): t(7;12)(q36;p13) and t(7;12)(q32;p13). Five patients with a t(7;12) were from a group of 125 successfully karyotyped pediatric patients enrolled in co
Autor:
Ursula Creutzig, Rob Pieters, A H Loonen, Monique L. den Boer, Dirk Reinhardt, Karel Hählen, Karin M. Kazemier, Gertjan J.L. Kaspers, Christian M. Zwaan
Publikováno v:
Blood. 107:4975-4977
Becton et al report the results of a trial in children with acute myeloid leukemia (AML) who were randomized to receive consolidation therapy with or without cyclosporine-A (CsA).[1][1] The authors measured P-glycoprotein (P-gp) expression in vitro b
Publikováno v:
British Journal of Haematology. 93:125-130
Activation of CD20, a cross-membrane ion channel, induces cell cycle progression from G0 to G1 in B lymphocytes. Subsequent activation of CD40, a membrane receptor of the nerve growth factor receptor superfamily, transits the B cells to the S phase.
Autor:
Marco Tartaglia, Henrik Hasle, Andreas Jung, Alessandra Fragale, Bruce D. Gelb, Charlotte M. Niemeyer, Xiaoling Song, Karel Hählen, Jochen Buechner, Jonathan D. Licht
Publikováno v:
Nature Genetics. 34:148-150
We report here that individuals with Noonan syndrome and juvenile myelomonocytic leukemia (JMML) have germline mutations in PTPN11 and that somatic mutations in PTPN11 account for 34% of non-syndromic JMML. Furthermore, we found mutations in PTPN11 i
Publikováno v:
Medical and Pediatric Oncology. 23:335-343
A randomized study was done in twenty newly diagnosed children with acute lymphoblastic leukemia. Ten children were treated with Escherichia coli L-asparaginase, and ten with Erwinia chrysanthemi L-asparaginase. L-asparaginase (ASP) treatment started