Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jingwei Cheng"'
Autor:
Megan E. Spurgeon, Jingwei Cheng, Ella Ward-Shaw, Frederick A. Dick, James A. DeCaprio, Paul F. Lambert
Publikováno v:
PLoS pathogens. 18(5)
Clear evidence supports a causal link between Merkel cell polyomavirus (MCPyV) and the highly aggressive human skin cancer called Merkel cell carcinoma (MCC). Integration of viral DNA into the human genome facilitates continued expression of the MCPy
Autor:
Patrick C Lee, Phuong Le, Keegan Korthauer, Jingwei Cheng, John Doench, James A. DeCaprio, Derin B. Keskin, Catherine J. Wu
Publikováno v:
The Journal of Immunology. 204:243.18-243.18
Loss of surface MHC I is an important mechanism by which cancer cells evade immune surveillance, and it can correlate with worse prognosis and resistance to immunotherapy. MHC I surface expression can be affected by genomic or transcriptional alterat
Autor:
Reety Arora, Peter M. Howley, Christian Berrios, Elizabeth A. White, Tengfei Xiao, Rhamy Zeid, Timothy Branigan, Selene K. Swanson, Thomas Westerling, Jingwei Cheng, Alexander J. Federation, Myles Brown, Michael P. Washburn, James A. DeCaprio, Donglim Esther Park, James E. Bradner, Benjamin J. Strober, Megha Padi, Laurence Florens, Rosa Yoon
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006668 (2017)
PLoS Pathogens
PLoS Pathogens
Merkel cell carcinoma (MCC) frequently contains integrated copies of Merkel cell polyomavirus DNA that express a truncated form of Large T antigen (LT) and an intact Small T antigen (ST). While LT binds RB and inactivates its tumor suppressor functio
Publikováno v:
Journal of Virology. 87:6118-6126
Merkel cell carcinoma (MCC) is a rare and aggressive form of skin cancer. In at least 80% of all MCC, Merkel cell polyomavirus (MCPyV) DNA has undergone clonal integration into the host cell genome, and most tumors express the MCPyV large and small T
Autor:
Vadim Molla, Donglim Esther Park, James A. DeCaprio, Christian Berrios, John Quackenbush, Megha Padi, Mark A. Keibler, Jingwei Cheng, Gregory Stephanopoulos, Soo Mi Lee
Publikováno v:
PLoS Pathogens
PLoS
PLoS Pathogens, Vol 12, Iss 11, p e1006020 (2016)
PLoS
PLoS Pathogens, Vol 12, Iss 11, p e1006020 (2016)
Merkel cell polyomavirus (MCPyV) is an etiological agent of Merkel cell carcinoma (MCC), a highly aggressive skin cancer. The MCPyV small tumor antigen (ST) is required for maintenance of MCC and can transform normal cells. To gain insight into cellu
Autor:
James A. DeCaprio, Chandra Sekhar Pedamallu, Joonil Jung, Robert L. Garcea, Christian Berrios, Michael Wang, Jingwei Cheng, Blake Primi, Christina Marcelus, Fujiko Duke, Matthew Meyerson
Publikováno v:
J. Virol. 89, 857-862 (2015)
Malawi polyomavirus (MWPyV) is a recently identified human polyomavirus. Serology for MWPyV VP1 indicates that infection frequently occurs in childhood and reaches a prevalence of 75% in adults. The MWPyV small T antigen (ST) binds protein phosphatas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5b1c14518aa3a97d9a683a2cec82bb
https://europepmc.org/articles/PMC4301141/
https://europepmc.org/articles/PMC4301141/
Autor:
Megha Padi, Anna Korkhin, James A. DeCaprio, Robert L. James, Michael A. Calderwood, Rosa Yoon, Jarrod A. Marto, Marc Vidal, Luxuan Guo, Christian Berrios, Ying Zhang, Jingwei Cheng, Soundarapandian Velmurgan, Laurence Florens, Guillaume Adelmant, Michael E. Cusick, Debrah A. Fine, Michael P. Washburn, David E. Hill, Orit Rozenblatt-Rosen, Larisa Litovchick
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002949 (2012)
PLoS Pathogens
PLoS Pathogens
The small genome of polyomaviruses encodes a limited number of proteins that are highly dependent on interactions with host cell proteins for efficient viral replication. The SV40 large T antigen (LT) contains several discrete functional domains incl
Autor:
Adam Calarese, Rachael A. Clark, Ying Jiang, Linda C. Wang, Chrysalyne D. Schmults, Victor Huang, Jessica E. Teague, A. Gehad, Mitra Dowlatshahi, Andrew DoRosario, Paul Nghiem, Jingwei Cheng, Carl F. Schanbacher, Manisha Thakuria
Publikováno v:
The Journal of investigative dermatology, vol 133, iss 7
The Journal of investigative dermatology
The Journal of investigative dermatology
Merkel cell carcinomas (MCCs) are rare but highly malignant skin cancers associated with a recently described polyomavirus. MCC tumors were infiltrated by T cells, including effector, central memory, and regulatory T cells. Infiltrating T cells showe