Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Herbert J. Zeh"'
Autor:
Abby D Ivey, B Matthew Fagan, Pranav Murthy, Michael T Lotze, Herbert J Zeh, Lori A Hazlehurst, Werner J Geldenhuys, Brian A Boone
Publikováno v:
Clinical and Experimental Immunology. 211:239-247
Neutrophil extracellular traps (NETs) occur when chromatin is decondensed and extruded from the cell, generating a web-like structure. NETs have been implicated in the pathogenesis of several sterile disease states and thus are a potential therapeuti
Autor:
Daolin Tang, Ling Zeng, Daniel J. Klionsky, Borong Zhou, Shan Zhu, Jianxin Jiang, Timothy R. Billiar, Guido Kroemer, Haichao Wang, Jiao Liu, Herbert J. Zeh, Rui Kang
Publikováno v:
Autophagy
Sepsis is the most common cause of death for patients in intensive care worldwide due to a dysregulated host response to infection. Here, we investigate the role of sequestosome-1 (SQSTM1/p62), an autophagy receptor that functions as a regulator of i
Publikováno v:
Clinical Colorectal Cancer. 17:25-31
Although some progress has been made in recent years with the development of more effective chemotherapy regimens, new treatment approaches are needed to improve outcomes for patients with pancreatic adenocarcinoma. The cellular process of autophagy,
Autor:
Herbert J. Zeh, Frank J. Jenkins, Simon C. Watkins, Ravikumar Muthuswamy, Pawel Kalinski, Dana H. Bovbjerg, Jill D. Henning, David L. Bartlett, Priscilla F. McAuliffe, Kandace P. McGuire, Nana J. Okada, Callen T. Wallace
Publikováno v:
Brain, Behavior, and Immunity. 62:78-86
Activation of the sympathetic nervous system (e.g., due to stress) has been implicated in cancer progression and recurrence, but its cancer-promoting effects have been variable between different studies. Here, we report that although catecholamines,
Autor:
Yixiang Zhen, Xiao Zhong, Ruochan Chen, Timothy R. Billiar, Xue Gong Fan, Haichao Wang, Daolin Tang, Yongmin Fu, Yan Huang, Pinhua Pan, Yangchun Xie, Rui Kang, Herbert J. Zeh, David L. Bartlett, Michael T. Lotze
Publikováno v:
Oncotarget
// Ruochan Chen 1, 2 , Yangchun Xie 2 , Xiao Zhong 1 , Yongmin Fu 1 , Yan Huang 1 , Yixiang Zhen 1 , Pinhua Pan 3 , Haichao Wang 4 , David L. Bartlett 2 , Timothy R. Billiar 2 , Michael T. Lotze 2 , Herbert J. Zeh, III 2 , Xue-Gong Fan 1 , Daolin Tan
Autor:
Stephanie Downs-Canner, Yongli Shuai, Anne Moon, David L. Bartlett, Judith Andrea McCart, Heather L. Jones, Caroline J. Breitbach, Roshni Ravindranathan, Herbert J. Zeh, Mark E. O'Malley, Zong Sheng Guo
Publikováno v:
Molecular Therapy
We have conducted a phase 1 study of intravenous vvDD, a Western Reserve strain oncolytic vaccinia virus, on 11 patients with standard treatment-refractory advanced colorectal or other solid cancers. The primary endpoints were maximum tolerated dose
Autor:
Michael T. Lotze, Mark A. Ross, Georgios I. Papachristou, Patricia Loughran, Aatur D. Singhi, Brian A. Boone, Pedram Paragomi, Pranav Murthy, Amer H. Zureikat, David C. Whitcomb, Herbert J. Zeh
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, Vol 10 (2019)
Background: Neutrophil extracellular traps (NETs) are generated when activated neutrophils, driven by PAD4, release their DNA, histones, HMGB1, and other intracellular granule components. NETs play a role in acute pancreatitis, worsening pancreatic i
Autor:
Ling Zeng, Ruochan Chen, Jiao Liu, Haichao Wang, Jianxin Jiang, Herbert J. Zeh, Shan Zhu, Daolin Tang, Rui Kang, Guido Kroemer, Timothy R. Billiar
Publikováno v:
Science Advances
Targeting immunometabolism is a strategy to prevent infection-mediated septic death.
The ability of cytosolic lipopolysaccharide (LPS) to activate caspase-11–dependent nonclassical inflammasome is intricately controlled to avoid excessive infl
The ability of cytosolic lipopolysaccharide (LPS) to activate caspase-11–dependent nonclassical inflammasome is intricately controlled to avoid excessive infl
Autor:
Daolin Tang, Herbert J. Zeh, Rui Kang, Aatur D. Singhi, W. Reed Doerfler, Xiaoyan Liang, Jennifer L. Miller-Ocuin, Michael T. Lotze, Brian A. Boone
Publikováno v:
Oncoimmunology
OncoImmunology, Vol 8, Iss 9 (2019)
OncoImmunology, Vol 8, Iss 9 (2019)
Neutrophil extracellular trap (NET) formation results in the expulsion of granulocyte proteins and DNA into the extracellular space. This process is mediated by the enzyme peptidyl arginine deiminase 4 (PADI4) and translocation of elastase to the nuc
Autor:
Rui Kang, Minghua Yang, Lizhi Cao, Guido Kroemer, Shan Zhu, Changfeng Li, Herbert J. Zeh, Daolin Tang
Publikováno v:
Oncoimmunology
OncoImmunology, Vol 7, Iss 6 (2018)
OncoImmunology, Vol 7, Iss 6 (2018)
Immunogenic cell death (ICD) is a type of cell death that is accompanied by the release of damage-associated molecular patterns (DAMPs) and results in a dead-cell antigen-specific immune response. Here, we report that spautin-1, an inhibitor of ubiqu