Zobrazeno 1 - 10
of 80
pro vyhledávání: '"George Kassiotis"'
Autor:
Huipeng Jiao, Laurens Wachsmuth, Simone Wolf, Juliane Lohmann, Masahiro Nagata, Göksu Gökberk Kaya, Nikos Oikonomou, Vangelis Kondylis, Manuel Rogg, Martin Diebold, Simon E. Tröder, Branko Zevnik, Marco Prinz, Christoph Schell, George R. Young, George Kassiotis, Manolis Pasparakis
Publikováno v:
Nature. 607:776-783
Mutations of theADAR1gene encoding an RNA deaminase cause severe diseases associated with chronic activation of type I interferon (IFN) responses, including Aicardi–Goutières syndrome and bilateral striatal necrosis1–3. The IFN-inducible p150 is
Autor:
George Kassiotis
Our defenses against infection rely on the ability of the immune system to distinguish invading pathogens from self. This task is exceptionally challenging, if not seemingly impossible, in the case of retroviruses that have integrated almost seamless
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0412d5178f41c37467be201a98b269e
Autor:
Jan Attig, Judith Pape, Laura Doglio, Anastasiya Kazachenka, Eleonora Ottina, George R. Young, Katey S.S. Enfield, Iker Valle Aramburu, Kevin W. Ng, Nikhil Faulkner, William Bolland, Venizelos Papayannopoulos, Charles Swanton, George Kassiotis
Increased levels and diversity of human endogenous retrovirus (HERV) transcription characterizes most cancer types, linked with disease outcomes. However, the underlying processes are incompletely understood. We show that elevated transcription of HE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f981cf8677b5246d4419e621d2a43568
Autor:
Laura Doglio, Georgina H. Cornish, George Kassiotis, Tom Lesluyes, Peter Van Loo, Anastasiya Kazachenka, Thomas Tüting, Eleonora Ottina, Veera Panova, Jan Attig, Kevin Litchfield, George R. Young, James I. MacRae, Charles Swanton, Joanna Kirkpatrick
Publikováno v:
Oncogene
The ubiquitin-proteasome system maintains protein homoeostasis, underpins the cell cycle, and is dysregulated in cancer. However, the role of individual E3 ubiquitin ligases, which mediate the final step in ubiquitin-mediated proteolysis, remains inc
Autor:
Charlotte Fribbens, Ben Shum, James Larkin, Robert J. Wilkinson, Charles Swanton, Maddalena Cerrone, Katalin A. Wilkinson, Sonia Gandhi, Karolina Rzeniewicz, Andrew Furness, John Shon, Wenyi Xie, Kate Young, Lisa Pickering, Kim Edmonds, George Kassiotis, Naureen Starling, Susana Banerjee, Nalinie Joharatnam-Hogan, Lyra Del Rosario, Lewis Au, David K. Lau, Annika Fendler, William Gordon, Fiona Byrne, Barry Ward, Ian Chau, Ruth Harvey, Scott Shepherd, Winston A. Haynes, Samra Turajlic, Camille L. Gerard, Eleanor Carlyle
Publikováno v:
Nature Medicine
Patients with cancer are currently prioritized in coronavirus disease 2019 (COVID-19) vaccination programs globally, which includes administration of mRNA vaccines. Cytokine release syndrome (CRS) has not been reported with mRNA vaccines and is an ex
Autor:
Timothy A C Snow, E. Garr, George Kassiotis, David Brealey, Catherine F Houlihan, Peter Cherepanov, Bryan Williams, Judith Heaney, Nishkantha Arulkumaran, Adarsh Kulkarni, Mervyn Singer, Moira J. Spyer, Eleni Nastouli, Michael P Lunn, Hannah Rickman, Chloe Rees-Spear, Gareth Ambler, Laura E. McCoy
Publikováno v:
Journal of Critical Care
Autor:
Dhira Joshi, Lucy R. Marshall, Lucy R. Wedderburn, Stavroula Paraskevopoulou, Steve Gamblin, Georgina H. Cornish, Sonia Gandhi, Charles Swanton, John W. McCauley, William Bolland, Svend Kjaer, Nikhil Faulkner, Hannah Rickman, Rachel Ulferts, Philip Hobson, D.J. Benton, Laura E. McCoy, Ana Agua-Doce, Rupert Beale, Annachiara Rosa, Chloe Roustan, Nicola O’Reilly, Catherine F Houlihan, Christopher Earl, Eleni Nastouli, A.G. Wrobel, Rachael Thompson, Brigitta Stockinger, Kirsty Thomson, Catherine Moore, Bethany R. Jebson, Anna Radziszewska, Coziana Ciurtin, Andrew Riddell, Saira Hussain, Emilie Sanchez, Peter Cherepanov, Elizabeth C. Rosser, Meredyth G. Ll Wilkinson, Kevin W. Ng, Ruth Harvey, Philip A. Walker, Hannah Peckham, Judith Heaney, Gee Yen Shin, Moira J. Spyer, George Kassiotis
Publikováno v:
Science (New York, N.y.)
Science
Science
Antibodies predating infection Immunological memory after infection with seasonal human coronaviruses (hCoVs) may potentially contribute to cross-protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ng et al. report that i
Autor:
Kevin W. Ng, Nikhil Faulkner, Katja Finsterbusch, Mary Wu, Ruth Harvey, Saira Hussain, Maria Greco, Yafei Liu, Svend Kjaer, Charles Swanton, Sonia Gandhi, Rupert Beale, Steve J. Gamblin, Peter Cherepanov, John McCauley, Rodney Daniels, Michael Howell, Hisashi Arase, Andreas Wack, David L.V. Bauer, George Kassiotis
Several variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged during the current coronavirus disease 2019 (COVID-19) pandemic. Although antibody cross-reactivity with the spike glycoproteins (S) of diverse coronaviruse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9844eb0423388638674fe85eede9527e
Autor:
Annika Fendler, Scott T.C. Shepherd, Lewis Au, Mary Wu, Ruth Harvey, Katalin A. Wilkinson, Andreas M. Schmitt, Zayd Tippu, Benjamin Shum, Sheima Farag, Aljosja Rogiers, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Justine Korteweg, Tara Foley, Taja Barber, Andrea Emslie-Henry, Niamh Caulfield-Lynch, Fiona Byrne, Daqi Deng, Svend Kjaer, Ok-Ryul Song, Christophe J. Queval, Caitlin Kavanagh, Emma C. Wall, Edward J. Carr, Simon Caidan, Mike Gavrielides, James I. MacRae, Gavin Kelly, Kema Peat, Denise Kelly, Aida Murra, Kayleigh Kelly, Molly O’Flaherty, Robyn L. Shea, Gail Gardner, Darren Murray, Sanjay Popat, Nadia Yousaf, Shaman Jhanji, Kate Tatham, David Cunningham, Nicholas Van As, Kate Young, Andrew J.S. Furness, Lisa Pickering, Rupert Beale, Charles Swanton, Sonia Gandhi, Steve Gamblin, David L.V. Bauer, George Kassiotis, Michael Howell, Emma Nicholson, Susanna Walker, Robert J. Wilkinson, James Larkin, Samra Turajlic
Patients with blood cancer continue to have a greater risk of inadequate immune responses following three COVID-19 vaccine doses and risk of severe COVID-19 disease. In the context of the CAPTURE study (NCT03226886), we report immune responses in 80
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad02cc3c652d4326fd926337a398448a
Autor:
Lisa Pickering, Richard Stone, Ian Chau, James I. MacRae, Karla Lingard, Susana Banerjee, Barry Ward, Jessica Bazin, William Gordon, Naureen Starling, Katalin A. Wilkinson, Mary O'Brien, Anna Robinson, Joanne Droney, Sacheen Kumar, Emma Nicholson, Martin Pule, Isla Leslie, Andreas M. Schmitt, Ambrosius P. Snijders, Karolina Rzeniewicz, Emma Nye, Benjamin Shum, Mary Mangwende, Scott Shepherd, Nalinie Joharatnam-Hogan, Robyn L. Shea, Michael Howell, Anthony J. Swerdlow, Shaman Jhanji, Simon Caidan, Eleanor Carlyle, Laura Amanda Boos, Annika Fendler, Kevin W. Ng, Kate Tatham, Leila Mekkaoui, Tim Slattery, Margaret Crawford, Firza Gronthoud, Philip Hobson, Camila Gomes, Robert J. Wilkinson, Jerome Nicod, Charles Swanton, Mike Gavrielides, Kim Edmonds, Robin L. Jones, Fiona Byrne, Laura Cubitt, Alison Reid, Lucy Holt, Ana Agua-Doce, Ruth Harvey, Sarah Sarker, Spyridon Gennatas, Camille L. Gerard, Andrew Furness, Hamid Ahmod, Liam Welsh, Nicholas van As, Olivia Curtis, Nadia Yousaf, Mary Wu, Nicholas C. Turner, Christina Messiou, David Cunningham, Zayd Tippu, Georgina H. Cornish, Sonia Gandhi, Helen R. Flynn, Harshil Patel, Yasir Khan, James Larkin, Lewis Au, George Kassiotis, Samra Turajlic, Maddalena Cerrone, Clemency Stephenson, Steve Gamblin, Kate Young, Wenyi Xie, Shreerang Bhide, Robert L. Goldstone, Alicia Okines, Kevin J. Harrington, Lyra Del Rosario
Publikováno v:
Nature Cancer
Research Square
article-version (status) pre
article-version (number) 1
Research Square
article-version (status) pre
article-version (number) 1
Patients with cancer have higher COVID-19 morbidity and mortality. Here we present the prospective CAPTURE study, integrating longitudinal immune profiling with clinical annotation. Of 357 patients with cancer, 118 were SARS-CoV-2 positive, 94 were s