Zobrazeno 1 - 10
of 12
pro vyhledávání: '"David Flyer"'
Autor:
Jing-Hui Tian, Michael J. Massare, Vadim A. Ivanov, Robert C. Welliver, Larry Ellingsworth, Gale Smith, Hanxin Lu, James F. Papin, Mimi Guebre-Xabier, David Flyer, Greg Glenn, Alisha Preno
Publikováno v:
Vaccine. 38(5)
Globally, human respiratory syncytial virus (RSV) is a major cause of severe lower respiratory infection in infants and young children. There are no licensed vaccines despite the high worldwide disease burden. RSV fusion (F) glycoprotein vaccine is t
Autor:
Xiaorui Chen, Jing-Hui Tian, Gale Smith, Jianpeng Ma, Ye Liu, Zhao Wang, Hanxin Lu, Fengyun Ni, Gregory M. Glenn, David Flyer, Nita Patel, Qinghua Wang, Qingqing Xie, Michael J. Massare, Larry Ellingsworth
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0210749 (2019)
PLoS ONE
PLoS ONE
Globally, human respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in newborns, young children, and the elderly for which there is no vaccine. The RSV fusion (F) glycoprotein is a major target for vaccine devel
Autor:
David Flyer, Louis Fries, Eloi Kpamegan, Gregory M. Glenn, Somia P. Hickman, Mimi Guebre-Xabier, Gale Smith, Hanxin Lu
Publikováno v:
Vaccine. 33(47):6488-6492
Background Protection of newborns and young infants against RSV disease via maternal immunization mediated by transplacental transfer of antibodies is under evaluation in third-trimester pregnant women with the RSV recombinant F nanoparticle vaccine
Autor:
D. Nigel Thomas, David Flyer, Eloi Kpamegan, Pedro A. Piedra, Dewal Jani, Somia P. Hickman, Gale Smith, Gregory M. Glenn, Hanxin Lu, Louis Fries
Publikováno v:
Journal of Infectious Diseases. 213:411-422
Background Respiratory syncytial virus (RSV) is a leading cause of infant morbidity and mortality. A recombinant RSV fusion protein nanoparticle vaccine (RSV F vaccine) candidate for maternal immunization was tested for safety and immunogenicity in w
Autor:
Irina Petrushina, David H. Cribbs, Hayk Davtyan, Lars Østergaard Pedersen, Anahit Ghochikyan, David Flyer, Jianmei Yu, Peter Juul Madsen, Michael G. Agadjanyan, Armine Hovakimyan
Publikováno v:
Journal of Neuroimmunology. 268:50-57
Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Es
Autor:
Michael R. Holbrook, Hiroaki Matsushita, Matthew B. Frieman, Jonathan T. Wang, Eddie Sullivan, Ye Liu, Stanley Perlman, Hua Wu, Rudragouda Channappanavar, Reed F. Johnson, Gene G. Olinger, Kanakatte Raviprakash, Elena Postnikova, Lisa E. Hensley, Christopher M. Coleman, Tadeusz J. Kochel, Jincun Zhao, Britini L. Ork, Jin An Jiao, Gregory M. Glenn, Gale Smith, Wensheng Nie, Jens H. Kuhn, Thomas C. Luke, Gabriel Defang, David Flyer
Publikováno v:
Nature Reviews. Drug Discovery
As of 13 November 2015, 1618 laboratory-confirmed human cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, including 579 deaths, had been reported to the World Health Organization. No specific preventive or therapeutic agent
Autor:
David Flyer, Kimber L. Poffenberger, D. Nigel Thomas, Gregory M. Glenn, Bo H. Andersen, Larry Ellingsworth, Sarah A. Frech
Publikováno v:
Vaccine. 27:G60-G66
Background: The use of adjuvants to enhance the immune response to novel pandemic influenza vaccine candidates may overcome the poor immune responses seen in immunologically naive populations. The confluence of a highly pathogenic H5N1 influenza viru
Autor:
Gregory M. Glenn, Robin McKenzie, Christina P. Villar, Sarah A. Frech, A. Louis Bourgeois, Robert M. Lavker, David Flyer
Publikováno v:
Infection and Immunity. 75:2163-2170
Transcutaneous immunization allows safe delivery of native heat-labile enterotoxin (LT) from Escherichia coli via application of a simple patch. Physical disruption of the stratum corneum can improve the efficiency of delivery. In the current study,
Autor:
Vladimir G. Frolov, Robert Chancey Seid, David Flyer, Larry Ellingsworth, Christian Ruiz, Jee Loon Look, Jason Schafer
Publikováno v:
Vaccine. 30(29)
Transcutaneous immunization (TCI) has become an attractive alternate route of immunization due to increase understanding of the skin immune system and to recent technical innovations in skin patch delivery systems. Basic principles of TCI have been d
Transcutaneous immunization with heat-labile enterotoxin: development of a needle-free vaccine patch
Autor:
Larry Ellingsworth, Gregory M. Glenn, Jianmei Yu, David Flyer, David Frerichs, Sarah A. Frech, Robert C. Seid
Publikováno v:
Expert review of vaccines. 6(5)
The skin is an attractive target for vaccine delivery. Adjuvants and antigens delivered into the skin can result in potent immune responses and an unmatched safety profile. The heat-labile enterotoxin (LT) from Escherichia coli, which acts both as an