Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Cindy Delbrook"'
Autor:
Brandon M. Wiley, Amita Kulshreshtha, Bonnie Yates, Daniel W. Lee, Stanislav Sidenko, Haneen Shalabi, Julia W. Cohen, Nirali N. Shah, Cindy Delbrook, Crystal L. Mackall, Vandana Sachdev, Doug R Rosing
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
BackgroundChimeric antigen receptor (CAR) T-cell-associated cytokine release syndrome (CRS) may present with tachycardia, hemodynamic instability and reduced cardiac function. Pediatric CAR studies examining cardiac toxicity are limited.MethodsWe rep
Autor:
Staci Martin, Robbie G. Majzner, Constance M. Yuan, Bonnie Yates, Jack F. Shern, Haneen Shalabi, Haiying Qin, David F. Stroncek, Marianna Sabatino, Terry J. Fry, Boro Dropulic, Cindy Delbrook, Yang Feng, Nirali N. Shah, Thomas J. Fountaine, Rimas J. Orentas, Daniel W. Lee, Crystal L. Mackall, Maryalice Stetler-Stevenson, Sneha Ramakrishna, Pamela L. Wolters, Dimiter S. Dimitrov, Ling Zhang, Sang M. Nguyen
Publikováno v:
Nature Medicine. 24:20-28
Chimeric antigen receptor (CAR) T cells targeting CD19 mediate potent effects in relapsed and/or refractory pre-B cell acute lymphoblastic leukemia (B-ALL), but antigen loss is a frequent cause of resistance to CD19-targeted immunotherapy. CD22 is al
Autor:
Eli Kane, Marie Claire Roderick, Staci Martin, Daniel W. Lee, Nirali N. Shah, Kari Struemph, Cindy Delbrook, Terry J. Fry, Crystal L. Mackall, Pamela L. Wolters, Haneen Shalabi, Mary Anne Toledo-Tamula, Bonnie Yates
Neurotoxicity associated with CAR-T cell therapy can be life-threatening. With rapid development of CAR-T therapies, a systematic method is needed to identify and monitor symptoms of neurotoxicity, elucidate potential etiologies, and compare toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddd097f65f1a686bb2854d871ecc08c
https://europepmc.org/articles/PMC6086728/
https://europepmc.org/articles/PMC6086728/
Autor:
Robert J. Kreitman, Constance M. Yuan, Kelly Richards, Cindy Delbrook, Alan S. Wayne, Nirali N. Shah, Ira Pastan, Maryalice Stetler Stevenson
Publikováno v:
Pediatric Blood & Cancer. 62:964-969
Background CD22 is a B-lineage differentiation antigen that has emerged as a leading therapeutic target in acute lymphoblastic leukemia (ALL).
Autor:
Crystal L. Mackall, Tolu Ariyo, Nirali N. Shah, David F. Stroncek, Terry J. Fry, Alan S. Wayne, Cindy Delbrook, David M. Loeb, Hahn Khuu, Mark Raffeld
Publikováno v:
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 22(12)
Relapse of hematologic malignancies is the primary cause of treatment failure after allogeneic hematopoietic stem cell transplantation (HCT). Treatment for post-HCT relapse using donor lymphocyte infusion (DLI) has limited utility, particularly in th
Autor:
Steven A. Rosenberg, Constance M. Yuan, Marianna Sabatino, Terry J. Fry, Ling Zhang, Hua Zhang, Crystal L. Mackall, Rimas J. Orentas, Alan S. Wayne, Steven A. Feldman, Maryalice Stetler-Stevenson, James N. Kochenderfer, Dave Stroncek, Cindy Delbrook, Nick Tschernia, Nirali N. Shah, Seth M. Steinberg, Daniel W. Lee, Yongzhi K Cui
Publikováno v:
Lancet (London, England). 385(9967)
Summary Background Chimeric antigen receptor (CAR) modified T cells targeting CD19 have shown activity in case series of patients with acute and chronic lymphocytic leukaemia and B-cell lymphomas, but feasibility, toxicity, and response rates of cons
Autor:
Staci Martin, Cindy Delbrook, Pamela L. Wolters, Terry J. Fry, Crystal L. Mackall, Haneen Shalabi, Nirali N. Shah, Daniel W. Lee, Bonnie Yates
Publikováno v:
Blood. 128:1625-1625
Introduction: Neurocognitive deficits and neurologic toxicity are known complications of ALL therapy, and cumulative therapy may make those with multiply relapsed disease more vulnerable. Novel targeted immunotherapies, such as blinatumomab or anti-C
Autor:
David F. Stroncek, Daniel W. Lee, Bonnie Yates, Ling Zhang, Constance M. Yuan, Hua Zhang, Maryalice Stetler-Stevenson, Steven A. Rosenberg, Cindy Delbrook, Terry J. Fry, Nirali N. Shah, Crystal L. Mackall, James N. Kochenderfer
Publikováno v:
Blood. 128:218-218
Relapsed pre-B acute lymphoblastic leukemia (ALL) portends a poor prognosis even with hematopoietic stem cell transplantation (HSCT). CD19 chimeric antigen receptor (CAR) T cells have shown promise in early studies although morbidity related tohigh g
Autor:
Kazusa Ishii, Haneen Shalabi, Bonnie Yates, Terry J. Fry, Nirali N. Shah, Crystal L. Mackall, Cindy Delbrook
Publikováno v:
Blood. 128:3358-3358
Background: Cytokine release syndrome (CRS) in the setting of CAR T cell therapy manifests as a wide constellation of symptoms with multi-organ involvement. CRS can vary from a mild, self-limited course to a life-threatening systemic inflammatory res
Autor:
Cindy Delbrook, Constance M. Yuan, David F. Stroncek, Nirali N. Shah, Terry J. Fry, Crystal L. Mackall, Ling Zhang, Maryalice Stetler-Stevenson, Daniel W. Lee, Bonnie Yates
Publikováno v:
Blood. 126:1324-1324
Background: Adoptive cellular therapy with genetically modified T-cells using viral-based vectors to express chimeric antigen receptors targeting the CD19 molecule have demonstrated dramatic clinical responses in patients ALL. However, not all patien