Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Cara, G."'
Autor:
Hiroaki Niiro, Aaron J. Marshall, Edward A. Clark, Sushma S. Thomas, Theodore J. Yun, Christine M. Disteche, Cara G. Lerner
Publikováno v:
The Journal of Experimental Medicine
We have identified and characterized a novel src homology 2 (SH2) and pleckstrin homology (PH) domain–containing adaptor protein, designated Bam32 (for B cell adaptor molecule of 32 kD). cDNAs encoding the human and mouse Bam32 coding sequences wer
Publikováno v:
The Journal of Immunology. 163:6631-6639
Anergic T cells display a marked decrease in their ability to produce IL-2 even in the presence of optimal TCR and costimulatory signals. Using IL-2 enhancer/promoter-driven reporter constructs, we have previously identified a region that appears to
Publikováno v:
The Journal of Immunology. 162:2775-2784
Costimulation (signal 2) has been proposed to inhibit the induction of T cell clonal anergy by either directly antagonizing negative signals arising from TCR engagement (signal 1) or by synergizing with signal 1 to produce IL-2, which in turn leads t
Autor:
Ohlén, Claes, Kalos, Michael, Cheng, Laurence E, Shur, Aaron C, Hong, Doley J, Carson, Bryan D, Kokot, Niels CT, Lerner, Cara G, Sather, Blythe D, Huseby, Eric S, Greenberg, Philip D
Publikováno v:
The Journal of experimental medicine, vol 195, iss 11
CD8+ T cell tolerance to self-proteins prevents autoimmunity but represents an obstacle to generating T cell responses to tumor-associated antigens. We have made a T cell receptor (TCR) transgenic mouse specific for a tumor antigen and crossed TCR-TG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b97f271b48e00d7cb77478a50a78be11
https://escholarship.org/uc/item/79k2p9db
https://escholarship.org/uc/item/79k2p9db
Autor:
Warren G. Tourtellotte, John Varga, Jun Wei, Cara G Gottardi, Swati Bhattacharyya, Monique Hinchcliff
Publikováno v:
Fibrogenesis & Tissue Repair
Fibrosis in systemic sclerosis (SSc), a complex polygenic disease associated with autoimmunity and proliferative/obliterative vasculopathy, shares pathobiologic features in common with other fibrosing illnesses, but also has distinguishing characteri
Autor:
Carla Giordano, Ida Pucci-Minafra, Desiree Martini, Ester Orsini, Patrizia Cancemi, Rosa Musso, Gianluca Di Cara, Nadia Ninfa Albanese, Maria Rita Marabeti
Thyroid carcinomas account for a minority of all malignant tumours but, after those of the gonads, they represent the most common forms of endocrine cancers. They include several types, among which the papillary thyroid cancer (PTC) and the anaplasti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::560358b7062207831028b5e4687d2d85
http://hdl.handle.net/10447/74479
http://hdl.handle.net/10447/74479
Autor:
Cristoforo Incorvaia, Franco Frati, Rachele Boccardo, Patrizia Berto, Giuseppe Di Cara, Paola Puccinelli, Ariano R, Stefania La Grutta
Publikováno v:
Annals of allergy, asthmaimmunology : official publication of the American College of Allergy, Asthma,Immunology. 103(3)
Background The worldwide increased prevalence of allergic diseases, and especially of respiratory allergy, is paralleled by increased health costs. This requires consideration of the cost to efficacy ratio of the available treatment to identify the o
Autor:
Aldo Galluzzo, Gianluca Di Cara, Patrizia Cancemi, Angela Criscimanna, Nadia Ninfa Albanese, Maria Pitrone, Antonina Coppola, Carla Giordano, Laura Tomasello, Giovanni Zito, Elvira Carissimi, Giuseppe Pizzolanti, Ida Pucci-Minafra, Alessandra Bommarito
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32109 (2012)
PLoS ONE
PLoS ONE
Type 1 diabetes mellitus (T1DM) is caused by the selective destruction of insulin-producing β-cells. This process is mediated by cells of the immune system through release of nitric oxide, free radicals and pro-inflammatory cytokines, which induce a