Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Winfred C Wang"'
Autor:
Winfred C. Wang, Juan Ding, Irene Agodoa, Guolian Kang, Jeremie H. Estepp, Ze Cong, M. Beth McCarville, Jane S. Hankins
Publikováno v:
Blood. 134:1002-1002
Introduction Sickle Cell Anemia (SCA) is a rare, devastating, and debilitating disease marked by the pathophysiologic features of hemolytic anemia, vaso-occlusion, and progressive end-organ damage. The most devastating complication of pediatric SCA i
Autor:
Winfred C. Wang, Margaret Tonda, Adlette Inati, Clark Brown, Connie M. Piccone, Carla Washington, Robert Liem, Sandy Dixon, Victor R. Gordeuk, Yifah Yaron, Gerald M. Woods, Erica Fong, Carolyn Hoppe, Ganesh Balaratnam, Josh Lehrer
Publikováno v:
Blood. 130:689-689
Background: Sickle cell disease (SCD) is a genetic disorder in which deoxygenation produces polymerization of mutated hemoglobin S (HbS) and triggers the downstream effects of red blood cell deformation (sickling), hemolysis, vaso-occlusion and infla
Autor:
Jeremie H. Estepp, Jane S. Hankins, Winfred C. Wang, Kathleen J. Helton, Jane E. Schreiber, Chen Li, Guolian Kang
Publikováno v:
ResearcherID
Background: Sickle cell anemia is associated with progressive compromise of neurocognitive function exacerbated by stroke or silent cerebral infarction. Despite decades of experience with chronic transfusion, hematopoietic stem cell transplantation,
Autor:
Robert J. Adams, Winfred C. Wang, Suzanne Granger, Miguel R. Abboud, Charles H. Pegelow, Jonathan S. Lewin, Joel K. Curé, Donald Brambilla, Lewis L. Hsu, Robert A. Zimmermann, Dianne Gallagher, Gerald M. Woods, Brian Berman
Publikováno v:
Blood. 103:2822-2826
The stroke prevention study in sickle cell disease (STOP) demonstrated a 90% reduction in stroke risk with transfusion among patients with time-averaged mean cerebral blood velocity (TAMV) of 200 cm/s or more as measured by transcranial Doppler (TCD)
Autor:
Dianne Gallagher, Eric A. Macklin, Ludovico Guarini, Thomas R. Kinney, Charles H. Pegelow, Michael R. DeBaun, Robert A. Zimmerman, Winfred C. Wang, Franklin G. Moser, Donald P. Younkin, Jacqueline A. Bello, Elliott Vichinsky, Scott T. Miller
Publikováno v:
Blood. 99:3014-3018
Children with sickle cell anemia (HbSS) are at high risk for neurologically overt cerebral infarcts associated with stroke and neurologically silent cerebral infarcts correlated with neuropsychometric deficit. We used complete magnetic resonance imag
Autor:
Abdullah Kutlar, Kathleen McKie, Margaret T. Lee, Carole Paley, Robert J. Adams, Nancy F. Olivieri, Rathi V. Iyer, Janet L. Kwiatkowski, Ofelia A. Alvarez, Miguel R. Abboud, Nadine Odo, Thomas V. Adamkiewicz, Julio C. Barredo, Elliott Vichinsky, Winfred C. Wang, Thomas D. Coates, Melanie Kirby-Allen, Gerald M. Woods, James F. Casella, Beatrice E. Gee, Virgil McKie
Publikováno v:
Blood. 114(21)
Chronic blood transfusion is increasingly indicated in patients with sickle cell disease. Measuring resulting iron overload remains a challenge. Children without viral hepatitis enrolled in 2 trials for stroke prevention were examined for iron overlo
Autor:
Kerri Nottage, Banu Aygun, Russell E. Ware, Jola Dowdy, Jane S. Hankins, Winfred C. Wang, Kathleen J. Helton, Matthew P. Smeltzer
Publikováno v:
Blood. 124:89-89
Background: Up to 40% of children with sickle cell anemia (SCA) will have abnormalities on brain imaging due to their hematologic disorder, much of which is subclinical. Common abnormalities on brain magnetic resonance imaging/magnetic resonance angi
Autor:
Molly Beth Freeman, Latacha Hamilton, Guolian Kang, Winfred C. Wang, Yvonne Carroll, Jane S. Hankins, Matthew P. Smeltzer, Banu Aygun
Publikováno v:
Blood. 124:4926-4926
Background: Central nervous system complications of sickle cell disease (SCD) include stroke, silent cerebral infarct, and neurocognitive deficits, but few studies have examined developmental delays in preschool-age children. Using the Brigance devel
Autor:
Courtney Thornberg, Ram V. Kalpathi, Zora R. Rogers, R. Clark Brown, Renee C. Rees, Rathi V. Iyer, James F. Casella, Scott T. Miller, Steven G. Pavlakis, Robert J. Adams, Winfred C. Wang, Judy Luden
Publikováno v:
Blood. 112:1436-1436
Introduction: Transcranial Doppler ultrasound (TCD) is used in children with sickle cell anemia (SCA) to detect stroke risk. TCD screening is mostly employed in children between 2–16 yrs of age; its use in infants Methods: All subjects underwent a
Autor:
Edwin M. Horwitz, Rupert Handgretinger, John M. Cunningham, Winfred C. Wang, Raymond C. Barfield, Joseph Woodard, Gregory A. Hale, Wing Leung, Russell E. Ware, Usman Yusuf
Publikováno v:
Blood. 106:5434-5434
Hematopoietic stem cell transplantation has been shown to be curative for approximately 83% of symptomatic children with sickle cell disease who have undergone the procedure. Despite these encouraging results, only 15% of children with symptoms that