Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Winfred C Wang"'
Autor:
Lori Luchtman-Jones, Jonathan C. Goldsmith, James F. Casella, Howard M. Lederman, Myron A. Waclawiw, Ram Kalpatthi, Margaret A. Connolly, Russell E. Ware, Andrea J. Swift, Winfred C. Wang
Publikováno v:
Pediatrics. 134:686-695
BACKGROUND AND OBJECTIVE: Susceptibility to encapsulated bacteria is well known in sickle cell disease (SCD). Hydroxyurea use is common in adults and children with SCD, but little is known about hydroxyurea’s effects on immune function in SCD. Beca
Autor:
Ashok Srinivasan, Aditya H. Gaur, Randall T. Hayden, Wing Leung, Zhengming Gu, Teresa Smith, Winfred C. Wang, Guolian Kang
Publikováno v:
Pediatric Blood & Cancer
Human rhinovirus (HRV), human coronavirus (hCoV), human bocavirus (hBoV), and human metapneumovirus (hMPV) infections in children with sickle cell disease have not been well studied.Nasopharyngeal wash specimens were prospectively collected from 60 c
Autor:
Mary Ellen Hoehn, Matthew P. Smeltzer, Banu Aygun, Jeremie H. Estepp, Winfred C. Wang, Jane S. Hankins
Publikováno v:
British Journal of Haematology. 161:402-405
Elevated foetal haemoglobin (HbF) levels are protective against some manifestations of sickle cell anaemia but the impact on retinopathy is unknown. We report on 123 children with HbSS, 10.6% of whom developed retinopathy. Independent of hydroxycarba
Autor:
Scott T. Miller, Rathi V. Iyer, Russell E. Ware, Zora R. Rogers, Bea Files, Barry L. Shulkin, John H. Miller, Eglal Shalaby-Rana, Winfred C. Wang, Bruce W. Thompson, Zhaoyu Luo, Peter A. Lane, Stephen D. Dertinger
Publikováno v:
Blood. 117:2614-2617
We evaluated spleen function in 193 children with sickle cell anemia 8 to 18 months of age by 99mTc sulfur-colloid liver-spleen scan and correlated results with clinical and laboratory parameters, including 2 splenic biomarkers: pitted cell counts (P
Autor:
Robert J. Adams, Winfred C. Wang, Suzanne Granger, Miguel R. Abboud, Charles H. Pegelow, Jonathan S. Lewin, Joel K. Curé, Donald Brambilla, Lewis L. Hsu, Robert A. Zimmermann, Dianne Gallagher, Gerald M. Woods, Brian Berman
Publikováno v:
Blood. 103:2822-2826
The stroke prevention study in sickle cell disease (STOP) demonstrated a 90% reduction in stroke risk with transfusion among patients with time-averaged mean cerebral blood velocity (TAMV) of 200 cm/s or more as measured by transcranial Doppler (TCD)
Autor:
Usman Yusuf, Xiaohua Chen, Ely Benaim, Wing Leung, John M. Cunningham, Winfred C. Wang, Gregory A. Hale, Rupert Handgretinger, Paul Woodard, Jim Houston, Kimberly A. Kasow, Edwin M. Horwitz
Publikováno v:
Bone Marrow Transplantation. 33:411-418
Peritransplant toxicity and a delay in effective immune reconstitution have limited the utility of alternate donor transplantation for children with refractory severe aplastic anemia. We have assessed the effectiveness of infusing large numbers of hi
Autor:
Dianne Gallagher, Eric A. Macklin, Ludovico Guarini, Thomas R. Kinney, Charles H. Pegelow, Michael R. DeBaun, Robert A. Zimmerman, Winfred C. Wang, Franklin G. Moser, Donald P. Younkin, Jacqueline A. Bello, Elliott Vichinsky, Scott T. Miller
Publikováno v:
Blood. 99:3014-3018
Children with sickle cell anemia (HbSS) are at high risk for neurologically overt cerebral infarcts associated with stroke and neurologically silent cerebral infarcts correlated with neuropsychometric deficit. We used complete magnetic resonance imag
Autor:
Vivien A. Sheehan, Jonathan M. Flanagan, Abdullah Kutlar, Winfred C. Wang, Thad A. Howard, Bruce W. Thompson, Russell E. Ware, Zhaoyu Luo
Publikováno v:
American journal of hematology. 88(7)
The recently completed BABY HUG trial investigated the safety and efficacy of hydroxyurea in infants with sickle cell anemia (SCA). To investigate the effects of known genetic modifiers, genomic DNA on 190 randomized subjects were analyzed for alpha
Autor:
George R. Buchanan, John M. Falletta, Clarice D. Reid, David L. Becton, Rathi V. Iyer, Neil J. Grossman, Ann B. Bjornson, Winfred C. Wang, Karen Kalinyak, Elliott Vichinsky, Gerald M. Woods, Helen S. Johnstone, Michael R. DeBaun, Joel Verter, C. Tate Holbrook, Doris L. Wethers, Gregory H. Reaman, Thomas R. Kinney, Charles H. Pegelow, Scott T. Miller
Publikováno v:
The Journal of Pediatrics. 129:828-835
OBJECTIVES: (1) To determine serotype-specific IgG antibody responses to reimmunization with pneumococcal polysaccharide vaccine at age 5 years in children with sickle cell anemia and (2) to determine whether continued penicillin prophylaxis had any
Autor:
Peter A. Lane, J. Paul Scott, Russell E. Ware, Lynn W. Wynn, Jane S. Hankins, Winfred C. Wang, Zora R. Rogers
Publikováno v:
Blood. 106(7)
The long-term efficacy and toxicity of hydroxyurea for infants are undefined, and its role in preventing organ dysfunction is unknown. Short-term feasibility of hydroxyurea administration, toxicities, hematologic effects, and effect on spleen functio