Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Paul A, Goepfert"'
Autor:
Michael S Piepenbrink, Jun-Gyu Park, Ashlesha Deshpande, Andreas Loos, Chengjin Ye, Madhubanti Basu, Sanghita Sarkar, Ahmed Magdy Khalil, David Chauvin, Jennifer Woo, Philip Lovalenti, Nathaniel B Erdmann, Paul A Goepfert, Vu L Truong, Richard A Bowen, Mark R Walter, Luis Martinez-Sobrido, James J Kobie
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010691 (2022)
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) marks the third novel β-coronavirus to cause significant human mortality in the last two decades. Although vaccines are available, too few have been administered worldwide to keep the viru
Externí odkaz:
https://doaj.org/article/cdcf68c2004649efa158bcfc0b8de359
Autor:
Kelly E. Seaton, Aaron Deal, Xue Han, Shuying S. Li, Ashley Clayton, Jack Heptinstall, Ann Duerr, Mary A. Allen, Xiaoying Shen, Sheetal Sawant, Nicole L. Yates, Paul Spearman, Gavin Churchyard, Paul A. Goepfert, Janine Maenza, Glenda Gray, Giuseppe Pantaleo, Laura Polakowski, Harriet L. Robinson, Shannon Grant, April K. Randhawa, Ying Huang, Cecilia Morgan, Nicole Grunenberg, Shelly Karuna, Peter B. Gilbert, M. Juliana McElrath, Yunda Huang, Georgia D. Tomaras, NIAID HIV Vaccine Trials Network (HVTN) 076, 088, 086, 096, 097, 205 Study Teams
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract We studied mucosal immune responses in six HIV-1 vaccine trials investigating different envelope (Env)-containing immunogens. Regimens were classified into four categories: DNA/vector, DNA/vector plus protein, protein alone, and vector alone
Externí odkaz:
https://doaj.org/article/2f212191b8044471a09de9b169fd03d0
Autor:
Stephen C De Rosa, Kristen W Cohen, Matthew Bonaparte, Bo Fu, Sanjay Garg, Catherine Gerard, Paul A Goepfert, Ying Huang, Daniel Larocque, M. Juliana McElrath, Daryl Morris, Robbert Van der Most, Guy deBruyn, Anke Pagnon
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 1, Pp n/a-n/a (2022)
Abstract Objectives We previously described the Phase I‐II evaluation of SARS‐CoV‐2 recombinant protein candidate vaccine, CoV2‐PreS‐dTM, with AF03‐ or AS03‐adjuvant systems (ClinicalTrials.gov, NCT04537208). Here, we further characteri
Externí odkaz:
https://doaj.org/article/a1cfa23ff2034272811b6634993dec22
Autor:
Sushma Boppana, Kai Qin, Jacob K Files, Ronnie M Russell, Regina Stoltz, Frederic Bibollet-Ruche, Anju Bansal, Nathan Erdmann, Beatrice H Hahn, Paul A Goepfert
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009761 (2021)
T-cell immunity is likely to play a role in protection against SARS-CoV-2 by helping generate neutralizing antibodies. We longitudinally studied CD4 T-cell responses to the M, N, and S structural proteins of SARS-CoV-2 in 26 convalescent individuals.
Externí odkaz:
https://doaj.org/article/e7e1d82743f64b859cd12f907c6caf75
Autor:
David C. Moylan, Paul A. Goepfert, Mirjam-Colette Kempf, Michael S. Saag, Holly E. Richter, Jiri Mestecky, Steffanie Sabbaj
Publikováno v:
Pathogens and Immunity, Vol 1, Iss 2, Pp 371-389 (2017)
Background:Tissue resident memory T cells (TrM) provide an enhanced response against infection at mucosal surfaces, yet their function has not been extensively studied in humans, including the female genital tract (FGT). Methods: Using polychromatic
Externí odkaz:
https://doaj.org/article/1380b56cadd54ea185106b344ec7bcd8
Autor:
Kai Qin, Sushma Boppana, Victor Y Du, Jonathan M Carlson, Ling Yue, Dario A Dilernia, Eric Hunter, Robbie B Mailliard, Simon A Mallal, Anju Bansal, Paul A Goepfert
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1007970 (2019)
HIV-1 frequently escapes from CD8 T cell responses via HLA-I restricted adaptation, leading to the accumulation of adapted epitopes (AE). We previously demonstrated that AE compromise CD8 T cell responses during acute infection and are associated wit
Externí odkaz:
https://doaj.org/article/3696d0d7ba3d4746ac4e5e12f2e06f3d
Autor:
Zdenek Hel, Jun Xu, Warren L Denning, E Scott Helton, Richard P H Huijbregts, Sonya L Heath, E Turner Overton, Benjamin S Christmann, Charles O Elson, Paul A Goepfert, Jiri Mestecky
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006087 (2017)
HIV-1 infection is associated with an early and profound depletion of mucosal memory CD4+ T cells, a population that plays an indispensable role in the regulation of isotype switching and transepithelial transport of antibodies. In this study, we add
Externí odkaz:
https://doaj.org/article/8743f1f8deb14ed98c593648f7ae4bbb
Autor:
Kai Qin, Wyatt J. McDonnell, Christian M Warren, Mina John, Abha Chopra, Simon Mallal, Silvana Gaudieri, Ling Yue, Rama Gangula, Becker M.P. Law, Shay Leary, Ramesh Ram, Mark A. Pilkinton, Paul A. Goepfert, Spyros A. Kalams, Louise Barnett, Jennifer Currenti, Anuradha Sooda, Sonya L. Heath, Anju Bansal, Eric Alves
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Loss of T cell immunogenicity due to mutations in virally encoded epitopes is a well-described adaptation strategy to limit host anti-viral immunity. Another described, but less understood, adaptation strategy involves the selection of mutations with
Autor:
Nathan Erdmann, Victor Y Du, Jonathan Carlson, Malinda Schaefer, Alexander Jureka, Sarah Sterrett, Ling Yue, Dario Dilernia, Shabir Lakhi, Jianming Tang, John Sidney, Jill Gilmour, Susan Allen, Eric Hunter, Sonya Heath, Anju Bansal, Paul A Goepfert
Publikováno v:
PLoS Pathogens, Vol 11, Iss 8, p e1005111 (2015)
Antiretroviral therapy, antibody and CD8+ T cell-mediated responses targeting human immunodeficiency virus-1 (HIV-1) exert selection pressure on the virus necessitating escape; however, the ability of CD4+ T cells to exert selective pressure remains
Externí odkaz:
https://doaj.org/article/1bf4c0c1b08c4c9cb362b059bfe5c528
Autor:
M. Juliana McElrath, Jack Heptinstall, Xiaoying Shen, Cecilia Morgan, Shuying S. Li, Harriet L. Robinson, Giuseppe Pantaleo, Shelly Karuna, Nicole L. Yates, Shannon Grant, Nicole Grunenberg, Glenda Gray, Peter B. Gilbert, Ashley Clayton, Laura Polakowski, April K. Randhawa, Sheetal Sawant, Mary Allen, Xue Han, Ying Huang, Janine Maenza, Kelly E. Seaton, Paul Spearman, Ann Duerr, Yunda Huang, Aaron Deal, Gavin J. Churchyard, Georgia D. Tomaras, Paul A. Goepfert
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
NPJ Vaccines
NPJ Vaccines
We studied mucosal immune responses in six HIV-1 vaccine trials investigating different envelope (Env)-containing immunogens. Regimens were classified into four categories: DNA/vector, DNA/vector plus protein, protein alone, and vector alone. We meas