Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Gijs R. van den Brink"'
Autor:
Trevor D. McKee, Toer W. Stevens, Peter Bossuyt, Borut Štabuc, Jenny Jeyarajah, Gregor Novak, Reena Khanna, Tanja van Viegen, Geert R. D'Haens, Ingrid C. Gaemers, Rish K. Pai, Brian G. Feagan, William J. Sandborn, Lisa M. Shackelton, Gijs R. van den Brink, Niels Vande Casteele, Vipul Jairath, Fred Fu, Guangyong Zou
Publikováno v:
Alimentary pharmacology & therapeutics, 49(11), 1401-1409. Wiley-Blackwell
Background: The appropriate location for biopsy procurement relative to an ulcer in active Crohn's disease is unknown. Aim: To explore the relationship between biopsy location, histological disease activity, proinflammatory gene expression and the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b7e652bf7b4812f9133bfc50641bea
https://pure.amc.nl/en/publications/evaluation-of-optimal-biopsy-location-for-assessment-of-histological-activity-transcriptomic-and-immunohistochemical-analyses-in-patients-with-active-crohns-disease(e411602a-777c-4102-90f9-f5f7ccf445a0).html
https://pure.amc.nl/en/publications/evaluation-of-optimal-biopsy-location-for-assessment-of-histological-activity-transcriptomic-and-immunohistochemical-analyses-in-patients-with-active-crohns-disease(e411602a-777c-4102-90f9-f5f7ccf445a0).html
Autor:
Ingrid B. Renes, Gijs R. van den Brink, Jacqueline L.M. Vermeulen, Sander Meisner, Vanesa Muncan, Ruurd M. van Elburg, Manon E. Wildenberg, Tânia Martins Garcia, Marit Navis
Publikováno v:
EMBO Reports
EMBO reports, 20(2):e46221. Wiley-Blackwell
EMBO reports, 20(2):e46221. Wiley-Blackwell
During the suckling‐to‐weaning transition, the intestinal epithelium matures, allowing digestion of solid food. Transplantation experiments with rodent fetal epithelium into subcutaneous tissue of adult animals suggest that this transition is int
Autor:
Lianne Koens, Patrick M.M. Bossuyt, Frank G. J. Kallenberg, Jarom Heijmans, Bartolomeus J. Meijer, Victorine H. Roos, Barbara A. J. Bastiaansen, Gijs R. van den Brink, Frederike J. Bemelman, Evelien Dekker
Publikováno v:
BMJ Open Gastroenterology, Vol 7, Iss 1 (2020)
BMJ open gastroenterology, 7(1):e000497. BMJ Publishing Group
BMJ Open Gastroenterology
BMJ open gastroenterology, 7(1):e000497. BMJ Publishing Group
BMJ Open Gastroenterology
ObjectiveAfter prophylactic colectomy, adenomas continue to develop in the remaining intestine of patients with familial adenomatous polyposis (FAP). There is a lack of standard clinical recommendation for chemoprevention in patients with FAP. Becaus
Autor:
John F. Baines, Sven Künzel, Triantafyllos Chavakis, Clemens Schafmayer, Esther Bosse, Giuseppina Luzzi, Jan Hendrik Egberts, Alexander Arlt, Andrea Ulbricht, Gijs R. van den Brink, Anne Strigli, Sebastian Zeissig, Jochen Hampe, Richard S. Blumberg, Thomas Becker, Kenneth Peuker, Arthur Kaser, Yvonne Zeissig, Stefan Schreiber, Marco Bianchi, Jun Wang, Stefanie Muff, Marijana Basic, André Bleich, Christoph Röcken
Publikováno v:
Nature Medicine
Nature medicine, 22(5), 506-515. Nature Publishing Group
Nature medicine, 22(5), 506-515. Nature Publishing Group
Inflammation-associated pathways are active in intestinal epithelial cells (IECs) and contribute to the pathogenesis of colorectal cancer (CRC). Calcineurin, a phosphatase required for the activation of the nuclear factor of activated T cells (NFAT)
Autor:
Manon E. Wildenberg, Tanya T.D. Soeratram, Wouter L. Smit, Sander Meisner, Jarom Heijmans, Claudia N. Spaan, Gijs R. van den Brink, Jacqueline L.M. Vermeulen, Amy S. Lee, B. Florien Westendorp, Bartolomeus J. Meijer, Jooske F. van Lidth de Jeude, Mattheus C. B. Wielenga, Vanesa Muncan
Publikováno v:
Cancer Res
Cancer research, 78(21), 6098-6106. American Association for Cancer Research Inc.
Cancer research, 78(21), 6098-6106. American Association for Cancer Research Inc.
Deletion of endoplasmic reticulum resident chaperone Grp78 results in activation of the unfolded protein response and causes rapid depletion of the entire intestinal epithelium. Whether modest reduction of Grp78 may affect stem cell fate without comp
Autor:
Gijs R. van den Brink, Sybren L. Meijer, Jessica R. de Bruyn, Willem A. Bemelman, Geert R. D'Haens, Manon E. Wildenberg
Publikováno v:
Journal of Crohn s & colitis, 9(11), 966-972. Elsevier
Background: Intestinal fibrosis is a process driven by chronic inflammation leading to increased presence of myofibroblasts and collagen deposition. Although strictures are rarely seen in ulcerative colitis [UC], longstanding disease is believed to c
Publikováno v:
Gastroenterology
Gastroenterology, 144(5), 873-876. W.B. Saunders Ltd
Gastroenterology, 144(5), 873-876. W.B. Saunders Ltd
The stem cell niche at the base of the intestinal crypts, as well as stemness and high clonogenicity in colon cancer cells, depend on Wnt signaling to β-catenin. Fibroblasts modulate the Wnt pathway in normal and neoplastic epithelial cells via uncl
Autor:
Daniel W. Hommes, Anne Christine W. Vos, Marjolijn Duijvestein, Maikel P. Peppelenbosch, Auke P. Verhaar, Gijs R. van den Brink, Manon E. Wildenberg, Mark Löwenberg
Publikováno v:
Journal of Immunology, 190(12), 6589-6595. American Association of Immunologists
Journal of immunology (Baltimore, Md., 190(12), 6589-6595. American Association of Immunologists
Journal of Immunology, 190(12), 6589-6595
Journal of immunology (Baltimore, Md., 190(12), 6589-6595. American Association of Immunologists
Journal of Immunology, 190(12), 6589-6595
The glucocorticoid receptor is present in a TCR-associated complex, which includes the Src family tyrosine kinase Lck. Glucocorticoids rapidly dissociate this complex, resulting in the inhibition of canonical Lck-phospholipase C (PLC)γ–dependent T
Autor:
Annette Schwartz Sterman, Bryant Shaughn H, Pim J. Koelink, Gijs R. van den Brink, Manon E. Wildenberg, Peter Bousquet, Jochen Salfeld, Bradford L. McRae, Alon D. Levin, Rajesh V. Kamath, Geert R. D'Haens, Igor Mikaelian
Publikováno v:
Journal of Crohn s & colitis, 10(1), 69-76. Elsevier
Background and Aims: Anti-tumour necrosis factor [TNF] monoclonal antibodies [infliximab, adalimumab] induce complete mucosal healing in a proportion of patients with Crohn’s disease whereas a TNF receptor fusion protein [etanercept] is not effecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5289073dc4cc698dbb66a2d87d935715
https://pure.amc.nl/en/publications/fc-receptormediated-effector-function-contributes-to-the-therapeutic-response-of-antitnf-monoclonal-antibodies-in-a-mouse-model-of-inflammatory-bowel-disease(8140adda-682d-489c-a0cc-88866e2a7050).html
https://pure.amc.nl/en/publications/fc-receptormediated-effector-function-contributes-to-the-therapeutic-response-of-antitnf-monoclonal-antibodies-in-a-mouse-model-of-inflammatory-bowel-disease(8140adda-682d-489c-a0cc-88866e2a7050).html
Autor:
Sanne L. Rosekrans, Viljar Jaks, Maria Kasper, James C. H. Hardwick, Anja Uhmann, G. Johan A. Offerhaus, Marius A. van den Bergh Weerman, Gijs R. van den Brink, Hein W. Verspaget, Heidi Hahn, Daan W. Hommes, Rune Toftgård, Willemijn A. van Dop, Jarom Heijmans
Publikováno v:
Gut, 62(3), 348-357. BMJ Publishing Group
Gut, 62(3), 348-357
Gut
Gut, 62(3), 348-357
Gut
Objective In the intestine Hedgehog (Hh) signalling is directed from epithelium to mesenchyme and negatively regulates epithelial precursor cell fate. The role of Hh signalling in the oesophagus has not been studied in vivo. Here the authors examined