Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sun, Jin"'
Autor:
Eun-Kyeong Jo, Chul-Su Yang, Mingyu Jung, Jin Kyung Kim, Jichan Jang, Yi Sak Kim, Hye-Mi Lee, Goo Taeg Oh, Jin-Man Kim, Sup Kim, Hyo Sun Jin, Tae Sung Kim
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 198(8)
The role of peroxisome proliferator–activated receptor α (PPAR-α) in innate host defense is largely unknown. In this study, we show that PPAR-α is essential for antimycobacterial responses via activation of transcription factor EB (TFEB) transcr
Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy
Autor:
Takamitsu Sasaki, Toru Nakamura, Robert R. Langley, Xuemei Wang, Yasuhiko Kitadai, Kim Anh Do, Toshio Kuwai, Sun Jin Kim, Isaiah J. Fidler, Dominic Fan, Jang Seong Kim
Publikováno v:
Clinical & Experimental Metastasis. 25:477-489
Immunohistochemical analysis of human colon cancers growing in the cecal walls of nude mice revealed that epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor 2 (VEGFR2) were expressed by different tumor cells and t
Autor:
Harry C. Blair, Dean Sheppard, Ken Patrene, Verónica García-Palacios, Sun Jin Choi, Ganwei Lu, Jolene J. Windle, Hiroshi Kajiya, Noriyoshi Kurihara, G. David Roodman, Hongwei Rao, Judy Anderson
Publikováno v:
Journal of Bone and Mineral Research. 21:1657-1665
We identified a previously unknown integrin, alpha(9)beta(1), on OCLs and their precursors. Antibody to alpha(9) inhibited OCL formation in human marrow cultures, and OCLs from alpha(9) knockout mice had a defect in actin ring reorganization and an i
Autor:
Christopher J. Logothetis, Joseph E. Busby, Marva Maya, Toru Nakamura, Sertac Yazici, Isaiah J. Fidler, Junqin He, Kim Anh Do, Xuemei Wang, Sun Jin Kim, Dominic Fan, Hisanori Uehara, Paul Mathew
Publikováno v:
JNCI: Journal of the National Cancer Institute. 98:783-793
Background: Inhibiting phosphorylation of platelet-derived growth factor receptor (PDGFR) by treatment with the PDGFR kinase inhibitor imatinib and the chemotherapeutic agent paclitaxel reduces the incidence and size of human prostate cancer bone les
Autor:
Monique B. Nilsson, Kenji Yokoi, Rachel Tsan, Sun Jin Kim, Junqin He, Isaiah J. Fidler, Sertac Yazici, Anil K. Sood, Premal H. Thaker
Publikováno v:
Clinical Cancer Research. 11:4923-4933
Purpose: We determined whether the administration of the tyrosine kinase inhibitor, AEE788, which targets the epidermal growth factor receptor and the vascular endothelial growth factor receptor, alone or in combination with paclitaxel, can inhibit p
Autor:
Premal H. Thaker, Do Hyun Nam, Sun Jin Kim, Junqin He, James L. Abbruzzese, Robert R. Rebhun, Sertac Yazici, Stanley R. Hamilton, Kenji Yokoi, Isaiah J. Fidler
Publikováno v:
Cancer Research. 65:3716-3725
We studied growth factors and their receptors in tumor cells and tumor-associated endothelial cells as the therapeutic targets in colon cancer. Immunohistochemical analysis of 13 surgical specimens of human colon adenocarcinoma revealed that both tum
Autor:
Junquin He, Isaiah J. Fidler, Paul Mathew, Sun Jin Kim, Sertac Yazici, Robert R. Langley, Hisanori Uehara, Dominic Fan
Publikováno v:
Cancer research. 65(9)
Prostate cancer cells metastasize to the bone where their interaction with osteoclasts and osteoblasts can lead to alterations in the structure of the bone. We determined whether the systemic administration of the bisphosphonate, zoledronate, could p
Autor:
Robert R. Langley, Dominic Fan, Isaiah J. Fidler, Robert B. Rebhun, Rachel Tsan, Sun Jin Kim, Junqin He
Publikováno v:
Cancer research. 64(11)
The activation of the microvascular endothelial cell platelet-derived growth factor (PDGF) receptor (PDGF-R) by PDGF has been implicated in neoplastic angiogenesis. Here, we established cultures of murine bone microvascular endothelial cells and exam
Autor:
Dominic Fan, Hisanori Uehara, Christopher J. Logothetis, Isaiah J. Fidler, Sun Jin Kim, Paul Mathew, David L. Shepherd, Takashi Karashima, Rachel Tsan, Jerald J. Killion
Publikováno v:
Journal of the National Cancer Institute. 95(6)
BACKGROUND Expression of platelet-derived growth factor (PDGF) and activation (by autophosphorylation) of its receptor (PDGF-R), a tyrosine kinase, are associated with the growth of metastatic prostate tumor cells in the bone parenchyma. The tyrosine
Autor:
Sun-Jin, Kim, Hisanori, Uehara, Takashi, Karashima, David L, Shepherd, Jerald J, Killion, Isaiah J, Fidler
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 9(3)
We determined whether blockade of the epidermal growth factor receptor (EGF-R) signaling pathway by oral administration of the EGF-R tyrosine kinase inhibitor (PKI 166) alone or in combination with injectable Taxol inhibits the growth of PC-3MM2 huma