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pro vyhledávání: '"Allison Berger"'
Autor:
Kristin E. Burke, Doug Bowman, Arijit Chakravarty, Mark D. Fleming, Jeffrey Ecsedy, A. A. McDonald, Vaishali Shinde, Stephen Tirrell, Stephen J. Blakemore, Allison Berger
Publikováno v:
Veterinary pathology. 51(1)
Immunohistochemistry-based biomarkers are commonly used to understand target inhibition in key cancer pathways in preclinical models and clinical studies. Automated slide-scanning and advanced high-throughput image analysis software technologies have
Autor:
Peter G. Smith, James J. Garnsey, Allison Berger, George Mullligan, Bradley Stringer, Michael D. Pickard, Jie Yu, Kristin E. Burke, Doug Bowman, Alice McDonald, Mark D. Fleming
Publikováno v:
Clinical Cancer Research. 16:A31-A31
The novel small molecule MLN4924 is an inhibitor of the NEDD8 activating enzyme (NAE) and is currently in Phase I trials. As part of the ubiquitin-proteasome system, NAE is required for activity of cullin ring ligases (CRLs), a category of ubiquitin