Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Magdalena Klanova"'
Autor:
Michael Svaton, Zuzana Zemanova, Marek Trneny, Zuzana Nahacka, Magdalena Klanova, Jan Soukup, Mariana Pacheco-Blanco, Dana Prukova, Kristina Forsterova, Eva Fronkova, Jana Karolova, Karel Helman, Ladislav Andera, Pavel Klener, Karla Svobodova, Eva Pokorná, Ondrej Havranek, Petra Vockova, Adela Berkova, Diana Tuskova
Publikováno v:
Clinical Cancer Research. 25:4455-4465
Purpose: Mantle cell lymphoma (MCL) is an aggressive subtype of B-cell non-Hodgkin lymphomas characterized by (over)expression of BCL2. A BCL2-targeting drug, venetoclax, has promising anticancer activity in MCL. We analyzed molecular mechanisms of v
Autor:
Pavle Krsmanovic, Heidi Mocikova, Kamila Chramostova, Magdalena Klanova, Marie Trnkova, Michal Pesta, Peter Laslo, Robert Pytlik, Tomas Stopka, Marek Trneny, Vit Pospisil
Publikováno v:
Cancers; Volume 14; Issue 9; Pages: 2305
Lymphoma with secondary central nervous system (CNS) involvement represents one of the most aggressive malignancies, with poor prognosis and high mortality. New diagnostic tools for its early detection, response evaluation, and CNS relapse prediction
Autor:
Magdalena, Klanova, Dmitry, Kazantsev, Eva, Pokorna, Tomas, Zikmund, Jana, Karolova, Matej, Behounek, Nicol, Renesova, Dana, Sovilj, Cristina D, Kelemen, Karel, Helman, Radek, Jaksa, Ondrej, Havranek, Ladislav, Andera, Marek, Trneny, Pavel, Klener
Publikováno v:
Mol. Cancer Ther. 21, 89-99 (2021)
The pro-survival MCL1 protein is overexpressed in many cancers, including B-cell non-Hodgkin lymphomas (B-NHL). S63845 is a highly specific inhibitor of MCL1. We analyzed mechanisms of sensitivity/resistance to S63845 in preclinical models of diffuse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b5042a29e167a06bd6977db7790bcb47
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63422
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63422
Autor:
Magdalena Klanova, Pavel Klener
Publikováno v:
Cancers
Cancers, Vol 12, Iss 938, p 938 (2020)
Cancers, Vol 12, Iss 938, p 938 (2020)
The ability to inhibit mitochondrial apoptosis is a hallmark of B-cell non-Hodgkin lymphomas (B-NHL). Activation of mitochondrial apoptosis is tightly controlled by members of B-cell leukemia/lymphoma-2 (BCL-2) family proteins via protein-protein int
Autor:
Pavel Klener, Magdalena Klanova
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2081 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2081 (2020)
Non-Hodgkin lymphomas (NHL) are lymphoid tumors that arise by a complex process of malignant transformation of mature lymphocytes during various stages of differentiation. The WHO classification of NHL recognizes more than 90 nosological units with p
Autor:
Petra Vockova, Emanuel Necas, Marek Trneny, Magdalena Klanova, Bokang Maswabi, Radek Jaksa, Dana Prukova, Jan Zivny, Lucie Lateckova, Vojtech Kulvait, Kyra Michalova, Jana Brezinova, Francisco J. Hernandez-Ilizaliturri, Tomáš Soukup, Martin Vokurka, Pavel Klener, Jan Molinsky
Publikováno v:
Laboratory Investigation. 94:806-817
Mantle cell lymphoma (MCL) is an aggressive type of B-cell non-Hodgkin lymphoma (NHL) associated with poor prognosis. Animal models of MCL are scarce. We established and characterized various in vivo models of metastatic human MCL by tail vein inject
Autor:
Magdalena Klanova, Jan Molinsky, Jan Zivny, Mahmudul Alam, Pavel Klener, Lucie Lateckova, Petra Vockova, Tomáš Soukup, Marek Trneny
Publikováno v:
Neoplasma. 63(5)
Mantle cell lymphoma is an aggressive type of B-cell non-Hodgkin lymphoma with adverse prognosis. It was demonstrated that alternation of CHOP and DHAP chemotherapy improved outcome of mantle cell lymphoma patients. However, which components of DHAP,
Autor:
Bokang Maswabi, Pavel Klener, Radek Jaksa, Karel Helman, Dana Vejmelkova, Roman Kodet, Robert Pytlik, Jan Molinsky, Jan Soukup, Dana Prukova, Marek Trneny, Magdalena Klanova, Simona Benesova, Jan Brazina, Petra Vockova, Lucie Lateckova, Ladislav Andera, Mahmudul Alam, Jan Svadlenka
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 22(5)
Purpose: To investigate the roles of BCL2, MCL1, and BCL-XL in the survival of diffuse large B-cell lymphoma (DLBCL). Experimental designs: Immunohistochemical analysis of 105 primary DLBCL samples, and Western blot analysis of 18 DLBCL cell lines fo
Autor:
Tabiwang N. Arrey, Mahmudul Alam, Michaela Scigelova, Magdalena Klanova, Petra Vockova, Jiri Petrak, Bokang Maswabi, Eliska Doktorova, Ondrej Vit, Pavel Klener, Jana Pospisilova, Lucie Lorkova
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135314 (2015)
PLoS ONE
PLoS ONE
Mantle cell lymphoma (MCL) is a chronically relapsing aggressive type of B-cell non-Hodgkin lymphoma considered incurable by currently used treatment approaches. Fludarabine is a purine analog clinically still widely used in the therapy of relapsed M
Autor:
Tomas Zikmund, Bokang Maswabi, Radek Jaksa, Dana Vejmelkova, Magdalena Klanova, Filipp Savvulidi, Marek Trneny, Mahmudul Alam, Lucie Lateckova, Jan Molinsky, Ludek Sefc, Pavel Klener, Petra Vockova, Dana Prukova, Martin Vokurka
Publikováno v:
ResearcherID
Mature B-cell lymphomas represent a heteregenous group of malignancies, which are considered to arise along different steps of B-cell development, particularly from germinal or post-germinal center B-cells. Recent studies, however, indicate that hema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e6a2f18c1f0f760bbc62c351f6a6ca
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349243504025&KeyUID=WOS:000349243504025
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349243504025&KeyUID=WOS:000349243504025