Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Vivien R. Sutton"'
Autor:
Kristin K. Brown, Ricky W. Johnstone, Ilia Voskoboinik, John Silke, Joseph A. Trapani, Stephin J. Vervoort, Conor J. Kearney, Andrew J. Freeman, Paul A. Beavis, Kelly M Ramsbottom, Vivien R. Sutton, Jessica Michie, Lizzy Pijpers, Phil Darcy, Simon J. Hogg, Deborah A. Knight, Jane Oliaro, Najoua Lalaoui
Publikováno v:
Science Immunology. 3
Immunotherapy has revolutionized outcomes for cancer patients, but the mechanisms of resistance remain poorly defined. We used a series of whole-genome clustered regularly interspaced short palindromic repeat (CRISPR)-based screens performed in vitro
Autor:
Joseph A. Trapani, Kevin Y. T. Thia, David M. Tarlinton, Vivien R. Sutton, Axel Kallies, Gabrielle T. Belz, Edwin D. Hawkins, Magdalena Hagn
Publikováno v:
The Journal of Immunology. 188:3886-3892
Recently, it has been reported that human B cells express and secrete the cytotoxic protease granzyme B (GrB) after stimulation with IL-21 and BCR cross-linking. To date, there are few clues on the function of GrB in B cell biology. As experimental t
Autor:
Joseph A. Trapani, Preethi Eldi, Dion Kaiserman, Antony Yaron Matthews, Iona S. Schuster, Geeta Chaudhri, Phillip I. Bird, Peter Fleming, Jérôme D. Coudert, Gunasegaran Karupiah, Christopher E. Andoniou, Mariapia A. Degli-Esposti, Kevin Y. T. Thia, Vivien R. Sutton, Matthew E. Wikstrom
Publikováno v:
PLoS Pathogens, Vol 10, Iss 12, p e1004526 (2014)
PLoS Pathogens
PLoS Pathogens
Many immune response genes are highly polymorphic, consistent with the selective pressure imposed by pathogens over evolutionary time, and the need to balance infection control with the risk of auto-immunity. Epidemiological and genomic studies have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7b9abed000c54e5bba532bbf4c5b20
https://hdl.handle.net/11541.2/119592
https://hdl.handle.net/11541.2/119592
Autor:
Joseph A. Trapani, Astrid A. Ruefli, Mark J. Smyth, Vivien R. Sutton, Joanne E. Davis, Ricky W. Johnstone
Publikováno v:
Drug Development Research. 52:549-557
It has now been demonstrated that chemotherapeutic drugs and killer cells can activate both common and unique programmed cell death pathways to effectively eliminate tumor cells. Although chemotherapy and radiation treatments are effective methods of
Publikováno v:
Immunology Today. 20:351-356
Viral strategies for escaping apoptosis have co-evolved with the immune system, resulting in a complex balance of pro- and anti-apoptotic forces in virus-infected cells under attack by cytotoxic T lymphocytes (CTLs). Here, Joseph Trapani and colleagu
Publikováno v:
Immunology and Cell Biology. 77:76-89
Cytotoxic T cells and natural killer cells together constitute a major defence against virus infection, through their ability to induce apoptotic death in infected cells. These cytolytic lymphocytes kill their targets through two principal mechanisms
General Introduction Cytotoxic lymphocytes and apoptosis The immune system of high-order organisms is a highly specialized compartment that eliminates transformed cells and cells infected with viruses or bacteria through a controlled process of cell-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed6b87b7a3d7499aea41a83abdb88f44
https://doi.org/10.1017/cbo9780511976094.010
https://doi.org/10.1017/cbo9780511976094.010
Autor:
Joseph A. Trapani, Vivien R. Sutton
Publikováno v:
Biological chemistry. 391(8)
Proteases of the serine and cysteine protease families are involved in many processes crucial to the lytic functions of cytotoxic T lymphocytes and natural killer cells. In this study we describe those functions and attempt to place them in the patho
Autor:
D. G. Penington, R. A. Harris, Ian F. C. McKenzie, Mauro S. Sandrin, Vivien R. Sutton, P. M. Hogarth
Publikováno v:
Journal of Cellular Physiology. 123:451-458
Using monoclonal antibodies, we have analysed the distribution of three recently described Qa antigenic determinants (Qa-m7, Qa-m8 and Qa-m9) on murine clonable hemopoietic progenitor cells and spleen colony-forming units (CFU-S). Cytotoxicity experi