Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Mandy L. Ford"'
Publikováno v:
Immunological Reviews. 292:225-242
One of the biggest barriers to achieving allograft tolerance is the presence of immunological memory within the recipient, which confers a faster, more robust immune response that is in most cases more resistant to pharmacologic immunosuppression. Th
Autor:
Ashley A. Miniet, Eileen M. Burd, Craig M. Coopersmith, Zhe Liang, Yini Sun, Mandy L. Ford, Takehiko Oami
Publikováno v:
Shock
Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the peri-junctional actin-myosin ring. Genetic deletion of myosin light chain kinase (MLCK) reverses intestinal h
Publikováno v:
Journal of Translational Critical Care Medicine. 1:89-95
The mucosal immune system plays a central role in the pathophysiology of health and disease. As the home to the largest population of lymphocytes in the body, the mucosal immune system closely communicates within other elements of the intestine, with
Autor:
Roshan P. George, Mandy L. Ford, Jennifer M. Robertson, Pamela D. Winterberg, Michael Kelleman
Publikováno v:
Journal of the American Society of Nephrology. 30:407-420
Background Uremic cardiomyopathy, characterized by left ventricular hypertrophy, diastolic dysfunction, and impaired myocardial strain, contributes to increased cardiovascular mortality in patients with CKD. Emerging evidence suggests a pathogenic ro
Publikováno v:
Transplant Immunology. 50:34-42
Models of infection have shaped our understanding of programmed memory T cell differentiation, yet whether these models apply to memory programming in the context of transplantation has yet to be defined. Previous work has identified differences in t
Autor:
Elise R. Breed, Eileen M. Burd, Rudolph L. Gleason, Benyam P. Yoseph, Craig M. Coopersmith, Zhe Liang, Carolyn A. Hilliard, Clayton R. Hunt, Ching-Wen Chen, Luke P. Brewster, Laura Hansen, Mandy L. Ford, Rohit Mittal, Tej K. Pandita
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
In vitro studies have implicated the small heat shock protein HSPB1 in a range of physiological functions. However, its in vivo relevance is unclear as the phenotype of unstressed HSPB1−/− mice is unremarkable. To determine the impact of HSPB1 in
Publikováno v:
iScience, Vol 23, Iss 4, Pp-(2020)
iScience
iScience
Summary Previous work has demonstrated that Th17 memory cells but not Th1 cells are resistant to CD28/CTLA-4 blockade with CTLA-4 Ig, leading us to investigate the individual roles of the CD28 and CTLA-4 cosignaling pathways on Th1 versus Th17 cells.
Autor:
Anna B. Morris, Mandy L. Ford
Publikováno v:
Curr Opin Organ Transplant
Purpose of review Studies on adaptive cells have largely focused on features that are specific to adaptive immunity. However, adaptive cells utilize innate cell features to modulate their responses, and this area of T and B-cell biology is understudi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bb1a89968e6e732cfd7a4e933c3d07
https://europepmc.org/articles/PMC7175961/
https://europepmc.org/articles/PMC7175961/
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in Immunology
Sepsis is a major cause of morbidity and mortality worldwide despite numerous attempts to identify effective therapeutics. While some sepsis deaths are attributable to tissue damage caused by inflammation, most mortality is the result of prolonged im
Autor:
Danya Liu, Maylene E. Wagener, G. Ding, Idelberto R. Badell, G. M. La Muraglia, Mandy L. Ford
Publikováno v:
American Journal of Transplantation. 18:89-101
Donor-specific antibodies (DSA) are a barrier to improved long-term outcomes following kidney transplantation. Costimulation blockade with CTLA-4-Ig has shown promise as a potential therapeutic strategy to control DSA. T follicular helper (Tfh) cells