Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Fernando Souza-Fonseca-Guimaraes"'
Publikováno v:
Seminars in Hematology. 57:194-200
Natural killer (NK) cells are an important component of the innate immune system, particularly for metastasis immunosurveillance. They can rapidly recognize and kill transformed cells without the requirement of specific neo-antigen recognition. Their
Autor:
Ariel Munitz, Kylie Luong, Andrew N. J. McKenzie, Jaring Schreuder, Wei Shi, Minyu Wang, Sharon Grisaru-Tal, Melissa J. Davis, Paul S. Foster, Joseph A. Trapani, Bogoljub Ciric, Sean Macdonald, Kevin Y. T. Thia, Soroor Hediyeh-Zadeh, Cynthia Louis, Ian P. Wicks, Stephen L. Nutt, Qiutong Huang, Jonathan Cebon, Shengbo Zhang, Daniel H.D. Gray, Paul J Neeson, Andreas Behren, Philip M. Hansbro, Cyril Seillet, Michael Chopin, Nicolas Jacquelot, Viktor Umansky, Angela Pizzolla, Joanna R Groom, Fernando Souza-Fonseca-Guimaraes, Mary J Camilleri, Tristan Molden-Hauer, Yang Liao, Eric Vivier, Carolyn A. de Graaf, Gabrielle T. Belz
Publikováno v:
Nature Immunology
Nature Immunology, 2021, 22 (7), pp.851-864. ⟨10.1038/s41590-021-00943-z⟩
Nature immunology
Nature Immunology, 2021, 22 (7), pp.851-864. ⟨10.1038/s41590-021-00943-z⟩
Nature immunology
International audience; Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer, ILC2s can harbor both pro-tumorigenic and anti-tumorigenic functions, but we know little about their underlying mechanisms or wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58b04f1a688fd896b85f7433ff098a9
https://hdl.handle.net/10453/155659
https://hdl.handle.net/10453/155659
Autor:
Andreas Behren, Fernando Souza-Fonseca-Guimaraes, Nicholas D. Huntington, Melissa J. Davis, Joseph Cursons, Soroor Hediyeh-Zadeh, Momeneh Foroutan, Ashley R. Anderson, Frédéric Hollande
Publikováno v:
Cancer Immunology Research. 7:1162-1174
Natural killer (NK) cell activity is essential for initiating antitumor responses and may be linked to immunotherapy success. NK cells and other innate immune components could be exploitable for cancer treatment, which drives the need for tools and m
Publikováno v:
Trends in Immunology. 40:142-158
Immune ‘checkpoint’ inhibitors can increase the activity of tumor-resident cytotoxic lymphocytes and have revolutionized cancer treatment. Current therapies block inhibitory pathways in tumor-infiltrating CD8+ T cells and recent studies have show
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 2, Pp n/a-n/a (2021)
Clinical & Translational Immunology
Clinical & Translational Immunology
Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help control local immune responses. Through natural cytotoxicity, production of cytokines and chemokines, and migratory capacity, NK cells play a vital immun
Autor:
Daniel Blashki, Ryan Stuchbery, Niall M. Corcoran, Chayanica Nasa, Anthony J. Costello, Stefano Mangiola, Fernando Souza-Fonseca-Guimaraes, Ken Chow, Simon Monard, Martin Modrak, Scott Williams, Paul J Neeson, Melanie Le Page, Christopher M. Hovens, Nicholas D. Huntington, Bhupinder Pal, Anthony T. Papenfuss, Patrick McCoy, Michael Kerger, Phil Dundee, Justin S. Peters, Natalie Lister, Simon P. Keam
Prostate cancer is caused by genomic aberrations in normal epithelial cells, however clinical translation of findings from analyses of cancer cells alone has been very limited. A deeper understanding of the tumour microenvironment is needed to identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c981e524c824f88f08b0ad621842fcd8
https://doi.org/10.1101/2020.03.16.993162
https://doi.org/10.1101/2020.03.16.993162
Autor:
Jonas B. Hess, Louis Irving, Tracy L. Leong, Jai Rautela, Stephanie R. Hyslop, Ariena Kersbergen, Nicholas D. Huntington, Matthew E. Ritchie, Joseph Cursons, Sarah A. Best, Melissa J. Davis, Daniel P Steinfort, Xueyi Dong, Kate D. Sutherland, Fernando Souza-Fonseca-Guimaraes
Publikováno v:
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 15(9)
Introduction SCLC is the most aggressive subtype of lung cancer, and though most patients initially respond to platinum-based chemotherapy, resistance develops rapidly. Immunotherapy holds promise in the treatment of lung cancer; however, patients wi
Autor:
Melissa J. Davis, Fernando Souza-Fonseca-Guimaraes, Nicholas D. Huntington, Rebecca B. Delconte, Soroor Hediyeh-Zadeh, Jai Rautela
Publikováno v:
Immunology and Cell Biology. 96:477-484
Natural Killer (NK) cells have long been considered an important part of the anti-tumor immune response due to their potent cytolytic and cytokine-secreting abilities. To date, a clear demonstration of the role NK cells play in human cancer is lackin
Autor:
Peter Fleming, Antiopi Varelias, Siok-Keen Tey, Mariapia A. Degli-Esposti, Kelli P. A. MacDonald, Bruce R. Blazar, Fernando Souza-Fonseca-Guimaraes, Rachel D. Kuns, Mark J. Smyth, Kelly R. Locke, Geoffrey R. Hill, Steven W. Lane, Katie E. Lineburg, Nicholas D. Huntington, Iona S. Schuster, Mark D. Bunting
Publikováno v:
Blood. 129:630-642
Allogeneic bone marrow transplantation (allo-BMT) is a curative therapy for hematological malignancies, but is associated with significant complications, principally graft-versus-host disease (GVHD) and opportunistic infections. Natural killer (NK) c
Autor:
Laura Kirby, Shatha AbuHammad, Richard J. Young, Peter Lau, Grant A. McArthur, Claire Martin, Katrina Meeth, Karen E. Sheppard, Jessica Michie, Kelly M Ramsbottom, Nicole M. Haynes, Rachael Walker, Fernando Souza-Fonseca-Guimaraes, Jane Oliaro, Emily J. Lelliott, Carleen Cullinane, Alison Slater
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Both targeted therapy and immunotherapy have been used successfully to treat melanoma, but the development of resistance and poor response rates to the individual therapies has limited their success. Designing rational combinations of targeted therap