Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Charles R. Mackay"'
Autor:
Sara Bordbar, Charles R. Mackay, Stephen M. Twigg, Eliana Mariño, Shannon Brodie, Sonia Saad, Marc R. Wilkins, Barbara Fazekas de St Groth, Long T. Nguyen, Emma E. Hamilton-Williams, Bree J. Tillett, Susan M. Corley, Courtney J. Wright, Helen M. McGuire, Yu Anne Yap, Kirstine J. Bell, Sussan Duong, Esteban Nicolas Gurzov, Leonard C. Harrison
BackgroundShort-chain fatty acids (SCFAs) produced by the gut microbiota have beneficial anti-inflammatory and gut homeostasis effects and prevent type 1 diabetes (T1D) in mice. Reduced SCFA production indicates a loss of beneficial bacteria, commonl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d99ceb0bb773c049b35a111f8cd051
https://doi.org/10.1101/2021.09.15.21263059
https://doi.org/10.1101/2021.09.15.21263059
Autor:
Duan Ni, Alexandra Sophie Angelatos, Charles R. Mackay, M.C.B. Amian, Claire Daien, Stephen J. Simpson, Remy Robert, M. Duraes, Jian Tan, S. Hoque, Alison K. Gosby, Rosilene V Ribeiro, Lake-Ee Quek, R. Audo, J. Mielle, Gabriela Pinget, A. Parmar, M.J. Alam, Laurence Macia, Frederic Sierro, James R. Krycer, G. Perkins
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 7 (2021)
JCI Insight, Vol 6, Iss 7 (2021)
Autoimmune diseases are characterized by a breakdown of immune tolerance partly due to environmental factors. The short-chain fatty acid acetate, derived mostly from gut microbial fermentation of dietary fiber, promotes antiinflammatory Tregs and pro
Autor:
Mercedes Davalos-Salas, Patrick G. Gavin, Yu Anne Yap, Jaclyn S. Pearson, Charles R. Mackay, Robert J. Moore, James L. Richards, Vik Ven Eng, Eliana Mariño, Julie M. Clarke, Trevor Lockett, Keiran H. McLeod, Emma E. Hamilton-Williams, Craig R. M. McKenzie
Publikováno v:
Clinical & Translational Immunology
Objectives During gastrointestinal infection, dysbiosis can result in decreased production of microbially derived short‐chain fatty acids (SCFAs). In response to the presence of intestinal pathogens, we examined whether an engineered acetate‐ or
Autor:
Charles R. Mackay
One explanation for the increased incidence of allergies, asthma, and certain autoimmune diseases has been the hygiene hypothesis. However, recent studies highlight the profound effects of diet and bacterial metabolites on disease in mouse models, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28b6c4bd03bca9bf35d91ceb38e1af74
https://doi.org/10.1016/b978-0-12-812102-3.00019-1
https://doi.org/10.1016/b978-0-12-812102-3.00019-1
Autor:
Charles R. Mackay, Hamdi A. Jama, Kirill Tsyganov, Gavin W. Lambert, D. Donner, Helen Kiriazis, Grant R Drummond, Sarah E. Phillips, Chad Johnson, Francine Z. Marques, Duncan Horlock, Waled A. Shihata, Antony Vinh, April Fiedler, Mark Ziemann, David M. Kaye, Matthew Snelson, Sam El-Osta, Beverly Giam, Xiao-Jun Du
Publikováno v:
Hypertension. 74
Background: High fibre intake is associated with lower blood pressure (BP) in epidemiological and clinical studies. Prebiotic fibre resists digestion in the upper gastrointestinal tract and is fermented by gut microbiota in the intestine. The impact
Publikováno v:
Immunological Reviews. 278:277-295
Dietary and bacterial metabolites influence immune responses. This raises the question whether the increased incidence of allergies, asthma, some autoimmune diseases, cardiovascular disease, and others might relate to intake of unhealthy foods, and t
Publikováno v:
Annual Review of Immunology. 35:371-402
Nutrition and the gut microbiome regulate many systems, including the immune, metabolic, and nervous systems. We propose that the host responds to deficiency (or sufficiency) of dietary and bacterial metabolites in a dynamic way, to optimize response
Autor:
Remy Robert, Charles R. Mackay
Publikováno v:
Immunology and Cell Biology. 96:341-343
See also: Outstanding Observation by Wirasinha et al., Short Communication by Barnes & Cyster.
Autor:
Steven Joung, Michael J. Peek, Ron Benzie, Charles R. Mackay, Kahlia Wong, David P. Eviston, Martin O'Hely, Eliana Mariño, Mingjing Hu, Yu Anne Yap, James L. Richards, David Wilson, Ann Louise Ponsonby, Ralph Nanan, Peter Hsu, Ann Quinton, Ann P. Chidgey, Peter Vuillermin, Mimi L.K. Tang, Jane E. Dahlstrom, Brigitte Santner-Nanan, Norelle L. Daly, Laurence Macia, Fiona Collier
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Maternal immune dysregulation seems to affect fetal or postnatal immune development. Preeclampsia is a pregnancy-associated disorder with an immune basis and is linked to atopic disorders in offspring. Here we show reduction of fetal thymic size, alt
Autor:
Luciana P. Tavares, Vitor T M Rocha, Charles R. Mackay, Cristiana C. Garcia, Flaviano S. Martins, Geovanni Dantas Cassali, Izabela Galvão, Caroline M. Ferreira, Angélica T. Vieira, Marco Aurélio Ramirez Vinolo, Mauro M. Teixeira, Marcela Rungue, Renan O. Corrêa, Sergio C. Oliveira, José Luís Fachi
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Pneumonia is one of the leading causes of death and mortality worldwide. The inflammatory responses that follow respiratory infections are protective leading to pathogen clearance but can also be deleterious if unregulated. The microbiota is known to