Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nils Rudqvist"'
Autor:
Silvia C. Formenti, Sylvia Gruber, Sandra Demaria, Sheila Spada, Claire Lhuillier, Erik Wennerberg, Xi Kathy Zhou, Steven S. Gross, Qiuying Chen, Nils Rudqvist, Fengli Zhang
Publikováno v:
Cancer Immunol Res
The ability of focal radiotherapy to promote priming of tumor-specific CD8+ T cells and increase responses to immunotherapy is dependent on infiltration of the tumor by Batf3-dependent conventional dendritic cell type 1 (cDC1) cells. Such infiltratio
Autor:
Daniel K. Wells, Erik Wennerberg, Benjamin G. Vincent, Christine N. Spencer, Heather M. McGee, Yana G. Najjar, Nils Rudqvist, Randy F. Sweis, Anne Monette, Houssein Abdul Sater, Uqba Khan, Maria Libera Ascierto, Cara Haymaker, Nicholas Tschernia, Praveen K. Bommareddy, Roberta Zappasodi, Vinita Popat, Sara Valpione, Alexandria P. Cogdill, Valentin Barsan, Vesteinn Thorsson, Wungki Park
Publikováno v:
Poster Presentations.
Background Immune checkpoint blockade (ICB) has revolutionized cancer treatment. However, long-term benefits are only achieved in a small fraction of patients. Understanding the mechanisms underlying ICB activity is key to improving the efficacy of i
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-10 (2019)
Genome Medicine
Genome Medicine
The expression of antigens that are recognized by self-reactive T cells is essential for immune-mediated tumor rejection by immune checkpoint blockade (ICB) therapy. Growing evidence suggests that mutation-associated neoantigens drive ICB responses i
Autor:
Xiangao Huang, Olivier Elemento, Peter Martin, Christina Y. Lee, Lorenzo Galluzzi, Nils Rudqvist, John P. Leonard, Selina Chen-Kiang, Maurizio Di Liberto, Kami J. Maddocks, Yang Hu, Nancy L. Bartlett
Publikováno v:
Blood. 134:3973-3973
Mantle cell lymphoma (MCL) is an incurable B-cell lymphoma characterized by the chromosomal translocation (11;14)(q13;q32), resulting in aberrant expression of cyclin D1 and dysregulated cell cycle progression. In a phase I clinical trial in patients
Autor:
Nils Rudqvist, Sheila Spada, Yasmeen Sarfraz, Karsten A. Pilones, Claire Vanpouille-Box, Silvia C. Formenti, Sandra Demaria, Julie M. Diamond, Jessica R. Chapman, Beatrix Ueberheide
Radiotherapy (RT) used at immunogenic doses leads to accumulation of cytosolic double-stranded DNA (dsDNA) in cancer cells, which activates type I IFN (IFN-I) via the cGAS/STING pathway. Cancer cell–derived IFN-I is required to recruit BATF3-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540ee630946b06286775eaab10ce8a90
https://europepmc.org/articles/PMC6072562/
https://europepmc.org/articles/PMC6072562/
Publikováno v:
Cancer Immunology Research. 6:PR02-PR02
Tumor-specific mutations can generate neoantigens, a class of major histocompatibility complex (MHC)-binding peptides that may be highly immunogenic because they are not expressed in healthy tissues and thus not subject to central thymic tolerance. R