Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Hendrik Schulze-Koops"'
Publikováno v:
Poster presentations.
Introduction Regulatory T cells (Tregs) play a critical role in maintaining homeostasis and limiting autoimmunity. The transcription factor Forkhead box P3 (Foxp3) has been identified as the key regulator of Treg function and development. Its activit
Immune regulation by peripheral suppressor T cells induced upon homotypic T cell/T cell interactions
Publikováno v:
Journal of Leukocyte Biology. 88:1041-1050
Activated effector T cells induce the generation of suppressor T cells from bystander memory T cells via interactions involving LFA-1 and its receptors. We have shown previously that homotypic interaction of resting memory CD4 T cells with activated
Publikováno v:
Bioconjugate Chemistry. 21:867-874
In this article, we present our results on the design of new polymeric carriers for antibodies. Polymer colloids based on poly(styrene-co-glycidyl methacrylate) were synthesized by surfactant-free emulsion polymerization. Obtained polymer particles s
Publikováno v:
Aktuelle Rheumatologie. 31:88-93
T-Zellen, insbesondere CD4+-T-Zellen, sind fur viele Aspekte der rheumatoiden Entzundungsreaktion verantwortlich. So zeigen CD4+-T-Zellen von Patienten mit rheumatoider Arthritis sowohl in der entzundeten Synovialmembran als auch in der peripheren Zi
Publikováno v:
European Journal of Immunology. 35:3631-3642
The role of p38 mitogen-activated protein kinase in primary human T cells is incompletely understood. We analyzed in detail the role of p38 in the regulation of effector functions and differentiation of human CD4 T cells by using a p38-specific inhib
Publikováno v:
The Journal of Immunology. 175:6107-6116
The mechanisms underlying the extrathymic generation of CD25+CD4 regulatory T cells (Tregs) are largely unknown. In this study the IL-4R α-chain-binding cytokines, IL-4 and IL-13, were identified as inducers of CD25+ Tregs from peripheral CD25−CD4
Autor:
Hans-Georg Kraetsch, Peter E. Lipsky, Hendrik Schulze-Koops, Alla Skapenko, Joachim R. Kalden
Publikováno v:
The Journal of Immunology. 166:4283-4292
To delineate the molecular mechanisms regulating Th2 cell differentiation, CD28-mediated generation of Th2 effectors was analyzed. In the absence of TCR ligation CD28 stimulation induced Th2 differentiation of memory but not of naive CD4+ T cells, wh
Publikováno v:
Immunologic Research. 19:25-34
Human CD4+ memory T cells progress through stages of postthymic differentiation that have been characterized by distinct phenotypes. We have investigated the factors regulating cytokine production, and the correlation between phenotype and effector f
Autor:
Hendrik Schulze-Koops, Iryna Prots, Katja Thümmler, Elisabeth Kremmer, Alla Skapenko, Peter E. Lipsky, Qihui Zhou, Sonja Haupt
Publikováno v:
J. Immunol. 190, 6579-6588 (2013)
Because of the numerous targets of microRNAs (miRNAs), functional dissection of specific miRNA/mRNA interactions is important to understand the complex miRNA regulatory mechanisms. Glycoprotein A repetitions predominant (GARP) is specifically express
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16913 (2011)
PLoS ONE
PLoS ONE
CD25+ regulatory T cells develop in the thymus (nTregs), but may also be generated in the periphery upon stimulation of naive CD4 T cells under appropriate conditions (iTregs). To gain insight into the mechanisms governing iTreg development, we perfo