Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Hoang Dai Tran"'
Autor:
Gert-Jan B. van Ommen, Willeke M. C. van Roon-Mom, Annemieke Aartsma-Rus, Melvin M. Evers, Ioannis Zalachoras, Hoang-Dai Tran, Onno C. Meijer, Johan T. den Dunnen
Publikováno v:
Nucleic Acid Therapeutics
Nucleic Acid Therapeutics, 24(1), 4-12
Nucleic Acid Therapeutics, 24(1), 4-12
Huntington's disease (HD) is a progressive autosomal dominant disorder, caused by a CAG repeat expansion in the HTT gene, which results in expansion of a polyglutamine stretch at the N-terminal end of the huntingtin protein. Several studies have impl
Autor:
Annemieke Aartsma-Rus, Gjb van Ommen, Sam Mulders, J.T. den Dunnen, Melvin M. Evers, Hoang-Dai Tran, Wmc van Roon-Mom, Jct van Deutekom
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 83:A52.1-A52
There has been a recent surge in research using antisense oligonucleotides (AONs) to reduce huntingtin transcript levels and thus huntingtin protein levels both in vitro an in vivo. This can be done in a non-allele specific manner by targeting both m