Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Zong-Wan Mao"'
Publikováno v:
Journal of medicinal chemistry. 65(21)
DNA damage repair is considered to be an important mechanism of cisplatin resistance, and the roles of iron homeostasis in action mechanisms of cisplatin have not been studied yet. Herein, a Pt(IV) prodrug (
Autor:
Xiao-Yu Xia, Juan He, Bing Liu, Liang-Nian Ji, Liu-Yi Liu, Hua-Gang Yao, Bo-Chen Zhu, Zong-Wan Mao, Wenting Liu, Bing-Bing Liang
Publikováno v:
Angewandte Chemie. 133:15468-15471
G-quadruplexes (G4s) are prevalent in oncogenes and proposed to be potential antitumor drug targets. However, binding selectivity of compounds to G4s still faces challenges. Herein, we report a platinum(II) complex ( Pt1 ), whose affinity to G4-DNA i
Publikováno v:
Journal of the American Chemical Society. 144(26)
The nucleic acid G-quadruplex (G4) has emerged as a promising therapeutic target for a variety of diseases such as cancer and neurodegenerative disease. Among small-molecule G4-binders, pyridostatin (PDS) and its derivatives (
Autor:
Jia-Ying Zhou, Wen-Jin Wang, Chen-Yu Zhang, Yu-Yi Ling, Xiao-Jing Hong, Qiao Su, Wu-Guo Li, Zong-Wan Mao, Bin Cheng, Cai-Ping Tan, Tong Wu
Publikováno v:
Biomaterials. 289
The alternations in the hypoxic and immune microenvironment are closely related to the therapeutic effect and prognosis of oral squamous cell carcinoma (OSCC). Herein, a new nanocomposite, TiOsub2/sub@Ru@siRNA is constructed from a ruthenium-based ph
Publikováno v:
Angewandte Chemie International Edition. 60:15095-15100
Ferroptosis regulates cell death through reactive oxygen species (ROS)-associated lipid peroxide accumulation, which is expected to affect the structure and polarity of lipid droplets (LDs), but with no clear evidence. Herein, we report the first exa
Publikováno v:
Chemistry – An Asian Journal. 17
Metal complexes have shown great potential in cancer immunotherapy. This review briefly introduces the basic concepts and strategies of cancer immunotherapy and summarizes the recent discoveries on the immune effects of traditional platinum-based ant
Publikováno v:
Molecules; Volume 27; Issue 9; Pages: 2629
As hypoxia is closely associated with tumor progression, proliferation, invasion, metastasis, and strong resistance to therapy, regulating and overcoming the hypoxia tumor microenvironment are two increasingly important aspects of tumor treatment. He
Publikováno v:
Chemistry – A European Journal. 27:5453-5460
Bacterial biofilms are a serious global health concern, often responsible for persistent infections. New strategies to prevent and treat bacterial infections by eradication of the biofilms are urgently needed. A novel ruthenium-based compound is repo
Publikováno v:
Chemical Communications. 57:1093-1096
Modulating the hypoxic microenvironment is the priority for tumor treatment. Cytometalated iridium(iii)-metformin conjugates were synthesized for treating hypoxic cancer cells for the first time, which alleviate hypoxia via mitochondria respiration i
Publikováno v:
ACS Applied Materials & Interfaces. 12:43444-43455
Cisplatin resistance in tumor cells is known mainly due to the reduced accumulation of platinum ions by efflux, detoxification by intracellular GSH, and nucleotide excision repair machinery-mediated nuclear DNA repair. In this work, theranostic Pt(IV