Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Yong-Chen Lu"'
Autor:
Sanghyun P. Kim, Nolan R. Vale, Nikolaos Zacharakis, Sri Krishna, Zhiya Yu, Billel Gasmi, Jared J. Gartner, Sivasish Sindiri, Parisa Malekzadeh, Drew C. Deniger, Frank J. Lowery, Maria R. Parkhurst, Lien T. Ngo, Satyajit Ray, Yong F. Li, Victoria Hill, Maria Florentin, Robert V. Masi, Biman C. Paria, Noam Levin, Alakesh Bera, Elizabeth A. Hedges, Agnes Choi, Praveen D. Chatani, Anup Y. Parikh, Shoshana Levi, Samantha Seitter, Yong-Chen Lu, Zhili Zheng, Todd D. Prickett, Li Jia, Jonathan M. Hernandez, Chuong D. Hoang, Paul F. Robbins, Stephanie L. Goff, Richard M. Sherry, James C. Yang, Steven A. Rosenberg
Publikováno v:
Cancer Immunology Research. 10:932-946
Adoptive cellular therapy (ACT) targeting neoantigens can achieve durable clinical responses in patients with cancer. Most neoantigens arise from patient-specific mutations, requiring highly individualized treatments. To broaden the applicability of
Autor:
Frank J. Lowery, Sri Krishna, Rami Yossef, Neilesh B. Parikh, Praveen D. Chatani, Nikolaos Zacharakis, Maria R. Parkhurst, Noam Levin, Sivasish Sindiri, Abraham Sachs, Kyle J. Hitscherich, Zhiya Yu, Nolan R. Vale, Yong-Chen Lu, Zhili Zheng, Li Jia, Jared J. Gartner, Victoria K. Hill, Amy R. Copeland, Shirley K. Nah, Robert V. Masi, Billel Gasmi, Scott Kivitz, Biman C. Paria, Maria Florentin, Sanghyun P. Kim, Ken-ichi Hanada, Yong F. Li, Lien T. Ngo, Satyajit Ray, Mackenzie L. Shindorf, Shoshana T. Levi, Ryan Shepherd, Chris Toy, Anup Y. Parikh, Todd D. Prickett, Michael C. Kelly, Rachel Beyer, Stephanie L. Goff, James C. Yang, Paul F. Robbins, Steven A. Rosenberg
Publikováno v:
Science
The accurate identification of antitumor T cell receptors (TCRs) represents a major challenge for the engineering of cell-based cancer immunotherapies. By mapping 55 neoantigen-specific TCR clonotypes (NeoTCRs) from 10 metastatic human tumors to thei
Autor:
Yong-Chen Lu, Xiao-Jing Wang
Publikováno v:
Molecular Carcinogenesis. 59:675-678
Publikováno v:
Cancer Immunol Res
Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) can mediate responses in some patients with metastatic epithelial cancer. Identifying gene signatures associated with successful ACT might enable the development of improved thera
Autor:
Jared J. Gartner, Yong-Chen Lu, Paul F. Robbins, Steven A. Rosenberg, Frank J. Lowery, Todd D. Prickett, Zhili Zheng
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundRecognition of neoantigens by T cells plays a major role in cancer immunotherapy. Identification of neoantigen-specific T-cell receptors (TCRs) has become a critical research tool for studying T cell-mediated responses after immunotherapy.
Autor:
Anna Pasetto, Yong-Chen Lu
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
T cells have been known to be the driving force for immune response and cancer immunotherapy. Recent advances on single-cell sequencing techniques have empowered scientists to discover new biology at the single-cell level. Here, we review the single-
Autor:
Yong-Chen Lu, Zhili Zheng, Piyush K. Agarwal, Steven A. Rosenberg, Vid Leko, Jared J. Gartner, Andrea B. Apolo, Lucas A McDuffie, Todd D. Prickett
Publikováno v:
J Immunol
Immune checkpoint inhibitors are effective in treating a variety of malignancies, including metastatic bladder cancer. A generally accepted hypothesis suggests that immune checkpoint inhibitors induce tumor regressions by reactivating a population of
Autor:
Lori McIntyre, Yong-Chen Lu, Liqiang Xi, Richard A. Morgan, Steven A. Feldman, Stephanie L. Goff, Parisa Malekzadeh, Lily Lu, Howard A. Fine, Richard M. Sherry, Nicholas P. Restifo, Monica Epstein, Zhili Zheng, Paul F. Robbins, Mark Raffeld, James Chih-Hsin Yang, Steven A. Rosenberg
Publikováno v:
J Immunother
A deletion variant of epidermal growth factor receptor (EGFRvIII) is a known driver mutation in a subset of primary and secondary glioblastoma multiforme. Adoptive transfer of genetically modified chimeric-antigen receptor (CAR) lymphocytes has demon
Autor:
Steven A. Rosenberg, Paul F. Robbins, Lien T. Ngo, Rami Yossef, Maria R. Parkhurst, Jared J. Gartner, Li Jia, Mohammad S. Jafferji, Anna Pasetto, Yong-Chen Lu, Abraham Sachs, Todd D. Prickett, Drew C. Deniger, Gal Cafri, Satyajit Ray
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
Nature Communications
T cells targeting shared oncogenic mutations can induce durable tumor regression in epithelial cancer patients. Such T cells can be detected in tumor infiltrating lymphocytes, but whether such cells can be detected in the peripheral blood of patients
Autor:
Harshini Chinnasamy, Todd D. Prickett, Li Jia, Paul F. Robbins, Isaac R. Kriley, Yasmine Assadipour, Steven A. Rosenberg, Steven A. Feldman, Stephanie L. Goff, Jared J. Gartner, Nikolaos Zacharakis, Jessica S. Crystal, John R. Wunderlich, Yong-Chen Lu, Robert Somerville, Mary A. Black, Lily Lu, Hui Xu, Zhili Zheng
Publikováno v:
Clinical Cancer Research. 23:4347-4353
Purpose: The administration of autologous tumor-infiltrating lymphocytes (TILs) can mediate durable tumor regressions in patients with melanoma likely based on the recognition of immunogenic somatic mutations expressed by the cancer. There are limite