Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Xiong, Xi"'
Autor:
Zheng-Xiong Xi, Omar Soler-Cedeño
Publikováno v:
Cells. 11(20)
Cannabinoid receptor 1 (CB1R) has been one of the major targets in medication development for treating substance use disorders (SUDs). Early studies indicated that rimonabant, a selective CB1R antagonist with an inverse agonist profile, was highly pr
Autor:
Briana, Hempel, Zheng-Xiong, Xi
Publikováno v:
Advances in pharmacology (San Diego, Calif.). 93
Cannabis legalization continues to progress in many US states and other countries. Δ
Autor:
Ewa, Galaj, Guo-Hua, Bi, Benjamin, Klein, Briana, Hempel, Anver Basha, Shaik, Emma S, Gogarnoiu, Jacob, Friedman, Jenny, Lam, Rana, Rais, John F, Reed, Shelley H, Bloom, Tracy L, Swanson, Jennifer L, Schmachtenberg, Amy J, Eshleman, Aaron, Janowsky, Zheng-Xiong, Xi, Amy Hauck, Newman
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 47(13)
The non-medical use of opioids has become a national crisis in the USA. Developing non-opioid pharmacotherapies for controlling this opioid epidemic is urgent. Dopamine D
Publikováno v:
Annu Rev Pharmacol Toxicol
The abuse of illicit psychostimulants such as cocaine and methamphetamine continues to pose significant health and societal challenges. Despite considerable efforts to develop medications to treat psychostimulant use disorders, none have proven effec
Autor:
Sara Santa-Cruz-Calvo, Emmanuel S. Onaivi, Jennifer F. O’Connell, Zheng-Xiong Xi, Qing-Rong Liu, Máire E. Doyle, Yun Wang, Hong Qu, Nicholas S. Huang, Josephine M. Egan, Isabel González-Mariscal
Publikováno v:
Acta Pharmacologica Sinica. 40:387-397
Targeting peripheral CB1R is desirable for the treatment of metabolic syndromes without adverse neuropsychiatric effects. We previously reported a human hCB1b isoform that is selectively enriched in pancreatic beta-cells and hepatocytes, providing a
Autor:
Ewa Galaj, Zheng-Xiong Xi
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 134, p 134 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 134, p 134 (2021)
Substance use disorder (SUD) is a serious public health problem worldwide for which available treatments show limited effectiveness. Since the legalization of cannabis and the approval of cannabidiol (CBD) by the US Food and Drug Administration, ther
Autor:
Zheng-Xiong Xi, Sophie L. Cemaj, Alexandra J. Gadiano, Anver Basha Shaik, Rana Rais, Jenny Lam, Vivek Kumar, Amy Hauck Newman, Barbara S. Slusher, Adrian M. Guerrero, Alessandro Bonifazi
Publikováno v:
J Med Chem
Dopamine D(3) receptors (D(3)R) play a critical role in neuropsychiatric conditions including substance use disorders (SUD). Recently, we reported a series of N-(3-hydroxy-4-(4-phenylpiperazin-1yl)butyl)-1H-indole-2-carboxamide analogues as high affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5f4d9f85fc14b5f81fc7f0712360f6
https://europepmc.org/articles/PMC8830247/
https://europepmc.org/articles/PMC8830247/
Publikováno v:
Pharmacol Biochem Behav
Publikováno v:
Neuropharmacology
Substance use disorders (SUD) are serious public health problems worldwide. Although significant progress has been made in understanding the neurobiology of drug reward and the transition to addiction, effective pharmacotherapies for SUD remain limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ca0004577f95c6f44e0e9b684e8ee9
https://europepmc.org/articles/PMC6745247/
https://europepmc.org/articles/PMC6745247/
Autor:
Malliga R. Iyer, Paul Paik, Eliot L. Gardner, Guo-Hua Bi, George R. Uhl, Kenner C. Rice, Agnieszka Sulima, Maria J. Martinez, Zheng-Xiong Xi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(45)
Receptor-type protein tyrosine phosphatase D (PTPRD) is a neuronal cell-adhesion molecule/synaptic specifier that has been implicated in addiction vulnerability and stimulant reward by human genomewide association and mouse cocaine-conditioned place-