Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Xiaoliang Jin"'
Publikováno v:
Drug metabolism and pharmacokinetics. 40
As a triterpene saponin, ilexsaponin A1 is one of the most abundant, representative and active components in plants of Ilex pubescens, used in the treatment of cardiovascular diseases. This study aimed to identify the metabolites of ilexsaponin A1 an
Autor:
Xiaoliang Jin, Qingyun Cai, Ping Ni, Jiali Liu, Guangji Wang, Jingwei Zhang, Meng Lu, Wenjie Wang, Fang Zhou
Publikováno v:
Redox Biology, Vol 15, Iss C, Pp 253-265 (2018)
Redox Biology
Redox Biology
Although metabolic reprogramming and redox imbalance are widely reported to be involved in chemo-resistance in cancer treatment, much more attention was paid to anti-cancer drug induced effect. Our previous studies showed that cancer cells can develo
Autor:
Yi Zhang, Zhimin Tang, Yuyao Wang, Bingqiao Shen, Ni Ni, Ping Gu, Min Luo, Xiaoliang Jin, Dandan Zhang, Hao Sun
Publikováno v:
Oncotarget
// Yi Zhang 1, * , Bingqiao Shen 1, * , Dandan Zhang 1, * , Yuyao Wang 1 , Zhimin Tang 1 , Ni Ni 1 , Xiaoliang Jin 1 , Min Luo 1 , Hao Sun 1 , Ping Gu 1 1 Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University S
Autor:
Yan Liu, Yuanwei Jia, Fang Zhou, Lan Yao, Xiaoliang Jin, Jingwei Zhang, Guangji Wang, Cheng Chen
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 158
Parecoxib (PX), a prodrug of valdecoxib (VX), is an injectable selective COX-2 inhibitor, and is recommended for the treatment of cancer pain. PX can be rapidly hydrolyzed into its active metabolite VX, and VX is further metabolized into hydroxylated
Autor:
Le Zhen, Xiao-Wen Yang, Liang Dai, Yu Shengqi, Guangji Wang, Xiaoliang Jin, Lan Yao, Haoliang Yuan, Xiaoan Wen, Hongbin Sun, Wenfeng Zhao
Publikováno v:
Journal of medicinal chemistry. 60(14)
Resistant HCV variants carrying NS5B S282T mutation confer reduced sensitivity to sofosbuvir, the sole marketed NS5B polymerase inhibitor. On the basis of the finding that 2'-α-F-2'-β-C-methylcytidine 5'-triphosphate (8) was more potent than sofosb
Autor:
Jingwei Zhang, Bingchen Ouyang, Le Zhen, Jianguo Sun, Xiaoliang Jin, Fang Zhou, Guangji Wang, Qianying Chen, Ying Peng
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 146
Tenofovir (TFV), a first-line anti-viral agent, has been prepared as various forms of prodrugs for better bioavailability, lower systemic exposure and higher target cells loading of TFV to enhance efficacy and reduce toxicity. TFV undergoes intracell
Autor:
Guangji Wang, Yu Wang, Jiye Aa, Ke-Rong Zhang, Bingchen Ouyang, Jianguo Sun, Zhen-Zhong Wang, Xiaoliang Jin, Wei Xiao, Shiyin Gu, Ying Peng, Yunxi Zhong
Publikováno v:
Scientific Reports
Guizhi Fuling capsule (GZFL), a traditional Chinese medicine formulation, is widely used in China to relieve pain from dysmenorrhea and is now in a Phase II clinical trial in the USA. Due to the low exposure of the five main medicative ingredients (a
Publikováno v:
Medicine
This report is to explore the long-term outcomes of surgical repair of bicanalicular lacerations in Chinese preschool patients. In this report, 12 patients with bicanalicular lacerations were studied between September 2010 and September 2015. The dis
Publikováno v:
Zhonghua yi xue za zhi. 94(9)
To investigated the effect of a hyperoncotic CPB-prime with hydroxyethyl starch (HES) 6% (130/0.4) on extravascular lung water (EVLW) and post-pump cardiac and pulmonary functions.This study plan approved by the hospital ethics committee review. In 4