Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Wei-Yi Ong"'
Autor:
Sneha Muralidharan, Long N. Nguyen, Thiet Minh Vu, Juat Chin Foo, Aaron Wei Liang Li, Mark Y. Chan, Toan Quoc Nguyen, Zafrul Hasan, Sang-Ha Baik, Madhuvanthi Chandrakanthan, Wei-Yi Ong, Amaury Cazenave-Gassiot, Markus R. Wenk, Sock Hwee Tan, Uyen Thanh Nha Le, Hoa Thi Thuy Ha, Federico Torta
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
We recently discovered that Mfsd2b, which is the S1P exporter found in blood cells. Here, we report that Mfsd2b is critical for the release of all S1P species in both resting and activated platelets. We show that resting platelets store S1P in the cy
Autor:
Venetia Kok Jing Tong, Sylvester Wong Shu Ming, Kah-Leong Lim, Ziyin Wang, Rafhanah Banu Bte Abdul Razar, Saravanan Gunaseelan, Sumitra Srimasorn, Wei-Yi Ong, John Jia En Chua
Publikováno v:
Human Molecular Genetics. 30:5-20
FEZ1-mediated axonal transport plays important roles in central nervous system development but its involvement in the peripheral nervous system is not well-characterized. FEZ1 is deleted in Jacobsen syndrome (JS), an 11q terminal deletion development
Autor:
Wei-Yi Ong, Samantha Chia Yi Ooi, Sally Shuxian Koh, Cao Qiong, Leona Ting Yuke Ho, Irwin K. Cheah, Barry Halliwell, Natalie Man Yin Lui, Deron R. Herr
Publikováno v:
NeuroMolecular Medicine
Neuromolecular Medicine
Neuromolecular Medicine
Ergothioneine (ET) is a naturally occurring antioxidant that is synthesized by non-yeast fungi and certain bacteria. ET is not synthesized by animals, including humans, but is avidly taken up from the diet, especially from mushrooms. In the current s
Publikováno v:
Molecular Neurobiology
The SARS-CoV-2 virus that is the cause of coronavirus disease 2019 (COVID-19) affects not only peripheral organs such as the lungs and blood vessels, but also the central nervous system (CNS)—as seen by effects on smell, taste, seizures, stroke, ne
Publikováno v:
Neuromolecular medicine. 24(4)
The SARS-CoV-2 virus gains entry to cells by binding to angiotensin-converting enzyme 2 (ACE2). Since circumventricular organs and parts of the hypothalamus lack a blood-brain barrier, and immunohistochemical studies demonstrate that ACE2 is highly e
Autor:
Sandra Soh, Wei-Yi Ong
Publikováno v:
Cells; Volume 11; Issue 3; Pages: 457
Cells, Vol 11, Iss 457, p 457 (2022)
Cells, Vol 11, Iss 457, p 457 (2022)
Withanolide A is a naturally occurring phytochemical that is found in Ashwagandha (Withania somnifera, fam. Solanaceae) or Indian Ginseng. In the current study, we elucidated the effect of withanolide A on 7-ketocholesterol (7KC) induced injury in hC
Autor:
Peiyan Wong, Wei Lun Seow, Wee Siong Chew, Deron R. Herr, Wei Wang, Federico Torta, Wei-Yi Ong, Ping Xiang, Jing Kai Chang, Raghav Sundar, Aishwarya Bandla, Markus R. Wenk, Brenda Wan Shing Lam, Kanokporn Chayaburakul, Violeta Lopez
Publikováno v:
Journal of Biological Chemistry. 295:1143-1152
Platinum-based therapeutics are used to manage many forms of cancer, but frequently result in peripheral neuropathy. Currently, the only option available to attenuate chemotherapy-induced neuropathy is to limit or discontinue this treatment. Sphingos
Autor:
Hidayat Lokman, Huck-Hui Ng, Audrey Tze Ting Khoo, Wei-Yi Ong, Junghyun Jo, Grace Lim, Hoang Dai Tran, Seung-Jae Lee, Weonjin Yu, Lin Yang, Lai Ping Yaw, Ya Yin Chang, Jessica Jiaxin Xie, Kah-Leong Lim, Bin Xiao, Eng-King Tan, Tzuen Yih Saw, Byung Chul Jung, Alfred Xuyang Sun, Hyunsoo Shawn Je
Publikováno v:
Annals of neurology. 90(3)
Objective: We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parki
Publikováno v:
Molecular Neurobiology. 57:372-392
Autotaxin (ATX) is a soluble extracellular enzyme that is abundant in mammalian plasma and cerebrospinal fluid (CSF). It has two known enzymatic activities, acting as both a phosphodiesterase and a phospholipase. The majority of its biological effect
Autor:
Xin Ying, Chua, Leona T Y, Ho, Ping, Xiang, Wee Siong, Chew, Brenda Wan Shing, Lam, Christopher P, Chen, Wei-Yi, Ong, Mitchell K P, Lai, Deron R, Herr
Publikováno v:
Neuromolecular medicine. 23(1)
Sphingosine 1-phosphates (S1Ps) are bioactive lipids that mediate a diverse range of effects through the activation of cognate receptors, S1P